DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myd88 and Il18rap

DIOPT Version :9

Sequence 1:	NP_001260821.1	Gene:	Myd88 / 35956	FlyBaseID:	FBgn0033402	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	XP_017452283.1	Gene:	Il18rap / 373540	RGDID:	727867	Length:	627	Species:	Rattus norvegicus

Alignment Length:	263	Identity:	54/263 - (20%)
Similarity:	100/263 - (38%)	Gaps:	80/263 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 NYSSSNNI---TVGQSVQILS-DEDQRC-------------VQMGQ--PLP--------RYNACV 247
            :|:.|:|:   ||...||:.: |||...             |::|:  .||        ||:..|
  Rat   221 DYTQSDNVSSWTVRAVVQVRTIDEDTNVKPDILDPVTDTLDVELGKAFTLPCRVQFGFQRYSKPV 285

  Fly   248 L--YA-----EADIDHATE--IMNNLESERYNLRLFLR---HRDMLMGVPFEHVQLSHFMATRCN 300
            :  |.     |.:|....|  |.:.|::|.....:|||   .||
  Rat   286 IKWYVKESTQEWEISEFVEKRIQSTLKNEVIEHTVFLREVTQRD--------------------- 329

  Fly   301 HLIVVLTEEFLRSPENTYLVNFTQKIQIENHTRKIIPILY----KTDMHIPQTLG---IYTH-IK 357
                 |:.:|:...:|: :.|.|:.|::..  ::.:..||    .|.|.:...:.   :|.| |:
  Rat   330 -----LSRKFVCFAQNS-IGNTTRTIRLRK--KEGVVFLYILLGMTVMLVGVLVAAALLYWHWIE 386

  Fly   358 YAGDSKLFNFWDKLARSLHDLDAFSIYSTRQVQTPSPVEESAPRVTTPSIRIQINDKDVTDMPNY 422
            .....:.|...|:..|...:.|||..|:    ...||..|:...::...:.:.:..:.:.:...|
  Rat   387 VVLLCRTFKNKDETLRDKKEFDAFVSYA----NWSSPETEATGSLSEEHLALNLFPEVLENTYGY 447

  Fly   423 NSC 425
            :.|
  Rat   448 SLC 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myd88	NP_001260821.1	DD	90..172	CDD:301326
Myd88	NP_001260821.1	TIR_2	242..375	CDD:304906	31/152 (20%)
Il18rap	XP_017452283.1	Ig_6	101..154	CDD:408247
		Ig	263..353	CDD:416386	24/116 (21%)
		Ig strand B	266..275	CDD:409353	2/8 (25%)
		Ig strand C	284..289	CDD:409353	1/4 (25%)
		Ig strand D	297..308	CDD:409353	2/10 (20%)
		Ig strand E	314..322	CDD:409353	1/7 (14%)
		Ig strand F	333..339	CDD:409353	1/5 (20%)
		Ig strand G	343..349	CDD:409353	2/5 (40%)
		TIR	410..558	CDD:396246	7/45 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910