DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myd88 and Il18r1

DIOPT Version :9

Sequence 1:	NP_001260821.1	Gene:	Myd88 / 35956	FlyBaseID:	FBgn0033402	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_032391.1	Gene:	Il18r1 / 16182	MGIID:	105383	Length:	537	Species:	Mus musculus

Alignment Length:	389	Identity:	74/389 - (19%)
Similarity:	133/389 - (34%)	Gaps:	117/389 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 HHHIYGATDVSYRRYRTAGMVVAEGVMDSGSGSGTGTGLGHFNETPLSALGIETRTQLSRMLNRK 101
            ||:     ...|...:|..:.|.|     |....|...||...|.....||.:.....|..||:.
Mouse   187 HHN-----GTRYNITKTVNITVIE-----GRSKVTPAILGPKCEKVGVELGKDVELNCSASLNKD 241

  Fly   102 KV----LRSEEGYQRDWRGISELAKQKGFVDENANNPMDLVLISW-SQRSPQTAKVGHL----EH 157
            .:    :|.|:....:   :.|..|:               ..:| |:.....:|:...    |:
Mouse   242 DLFYWSIRKEDSSDPN---VQEDRKE---------------TTTWISEGKLHASKILRFQKITEN 288

  Fly   158 FLGIIDRWDVCDDIQENLAKDTQRFIMKQEQRQTALVEACPPPPSDCFETNNNYSSSNNITVGQS 222
            :|.::....|.::    .|.||:.|::.:::        .|..|...|            |.|.:
Mouse   289 YLNVLYNCTVANE----EAIDTKSFVLVRKE--------IPDIPGHVF------------TGGVT 329

  Fly   223 VQILSDEDQRCVQMGQPLPRYNACVLY-----------AEAD----------------------- 253
            |.:|:.....|:.:        .||:|           ||.|
Mouse   330 VLVLASVAAVCIVI--------LCVIYKVDLVLFYRRIAERDETLTDGKTYDAFVSYLKECHPEN 386

  Fly   254 ---IDHATEIMNNLESERYNLRLFLRHRDMLMGVPFEHVQLSHFMATRCNHLIVVLTEEFLRSPE 315
               ...|.|.:..:..:::..:|.:..||::.|...  |:..|.:..:...||:||::.:|.:..
Mouse   387 KEEYTFAVETLPRVLEKQFGYKLCIFERDVVPGGAV--VEEIHSLIEKSRRLIIVLSQSYLTNGA 449

  Fly   316 NTYLVNFTQKIQIENHTRKIIPILYKTDMHI---PQTLGI---YTHIKYAGDSKLFN--FWDKL 371
            ...|.:...:..:|... |||.|.:....:|   |.:|.:   |..:|:..||...|  ||..|
Mouse   450 RRELESGLHEALVERKI-KIILIEFTPASNITFLPPSLKLLKSYRVLKWRADSPSMNSRFWKNL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myd88	NP_001260821.1	DD	90..172	CDD:301326	13/90 (14%)
Myd88	NP_001260821.1	TIR_2	242..375	CDD:304906	36/175 (21%)
Il18r1	NP_032391.1	IG_like	26..112	CDD:214653
		Ig	131..205	CDD:386229	5/22 (23%)
		PHA02785	<157..257	CDD:165149	18/79 (23%)
		TIR	374..534	CDD:366714	30/142 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910