DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myd88 and TOLL1A

DIOPT Version :9

Sequence 1:	NP_001260821.1	Gene:	Myd88 / 35956	FlyBaseID:	FBgn0033402	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	XP_309197.1	Gene:	TOLL1A / 1270495	VectorBaseID:	AGAP001004	Length:	1152	Species:	Anopheles gambiae

Alignment Length:	205	Identity:	53/205 - (25%)
Similarity:	82/205 - (40%)	Gaps:	52/205 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 YNACVLYAEADIDHATE-IMNNLESERYNLRLFLRHRDMLMGVPFEHV--QLSHFMATRCNHLIV 304
            |:|.|.|:..|....|| ::..||.:..|.:|....||.   .|.|.:  |:|. ...:....|:
Mosquito   897 YDAFVSYSHKDEAFITEHLVPTLERDPMNFKLCWHVRDW---TPGEMISSQISS-SVEQSRRTII 957

  Fly   305 VLTEEFLRSPENTYLVNF-TQKIQ--IENHTRKIIPI------LYKTDMHIPQTLGIYTHIKYAG 360
            ||:..||.|....  :.| |..:|  .|...|.||.|      :|..:..:...|...|:::: |
Mosquito   958 VLSSSFLESLWGQ--LEFRTAHLQSMAERRNRLIIIIYGDIGNIYDLEPELRAYLHTNTYVRW-G 1019

  Fly   361 DSKLFNFWDKLARSL-HD---LDAFSIYST--------------RQVQTPSPVEE---------- 397
            |..   |||||..:: |.   ..|....||              :|:|..:||::
Mosquito  1020 DPW---FWDKLRFAMPHPPKVRGASGTASTVVKSGVSTAGGLFMKQLQGAAPVDDRLELIKPQVT 1081

  Fly   398 --SAPRVTTP 405
              :.|.:|||
Mosquito  1082 PATPPALTTP 1091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myd88	NP_001260821.1	DD	90..172	CDD:301326
Myd88	NP_001260821.1	TIR_2	242..375	CDD:304906	41/143 (29%)
TOLL1A	XP_309197.1	LRR_8	<153..193	CDD:290566
		leucine-rich repeat	163..184	CDD:275380
		LRR_RI	<176..412	CDD:238064
		leucine-rich repeat	185..207	CDD:275380
		LRR_8	206..266	CDD:290566
		leucine-rich repeat	208..231	CDD:275380
		leucine-rich repeat	232..255	CDD:275380
		LRR_8	254..311	CDD:290566
		leucine-rich repeat	256..279	CDD:275380
		leucine-rich repeat	280..353	CDD:275380
		leucine-rich repeat	304..329	CDD:275380
		LRR_8	328..388	CDD:290566
		leucine-rich repeat	330..351	CDD:275380
		LRR_RI	351..580	CDD:238064
		leucine-rich repeat	354..377	CDD:275380
		LRR_8	378..436	CDD:290566
		leucine-rich repeat	378..401	CDD:275380
		leucine-rich repeat	402..425	CDD:275380
		leucine-rich repeat	426..449	CDD:275380
		leucine-rich repeat	450..468	CDD:275380
		LRR_8	506..565	CDD:290566
		leucine-rich repeat	507..530	CDD:275380
		leucine-rich repeat	549..576	CDD:275380
		LRRNT	666..702	CDD:214470
		leucine-rich repeat	691..734	CDD:275380
		LRR_8	709..767	CDD:290566
		leucine-rich repeat	735..756	CDD:275380
		TIR	897..1034	CDD:214587	41/146 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910