DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myd88 and XB5889249

DIOPT Version :9

Sequence 1:	NP_001260821.1	Gene:	Myd88 / 35956	FlyBaseID:	FBgn0033402	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	XP_017950848.2	Gene:	XB5889249 / 100495326	XenbaseID:	XB-GENE-5889250	Length:	796	Species:	Xenopus tropicalis

Alignment Length:	346	Identity:	73/346 - (21%)
Similarity:	117/346 - (33%)	Gaps:	117/346 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 HHHI------YGATDVSYRRYRTAGMVVAEGVMDSGSGSGTGTGLGHFNETPLSALGIETRTQLS 95
            ||.|      |...||.:.:......:.||.::::.:.|  ..|:.||...|:.:        :.
Frog   296 HHSIKSFTLEYFTNDVFFFQGTHPFNIFAEMLVENVTFS--NAGMIHFFCPPVPS--------IV 350

  Fly    96 RMLNRKKVLRSEEGYQRDWRGISELAKQKGFVDENANNPMDLV------LISWSQRSPQTAKVGH 154
            |.||..                |.....:.|::.::.|.::|:      |...|:.|..|.|:.:
Frog   351 RFLNLP----------------SNRITDEIFLNCSSLNELELLNLQNNKLEQMSKISSMTLKMKN 399

  Fly   155 LEHFLGIIDRWDVCDDIQEN-LAKDTQR---------FIMKQEQRQTALVEACPPPPSDCFETNN 209
            |:|.           |:.:| |..|.::         |:...|...|..|..|.|......:.:.
Frog   400 LKHL-----------DLSKNGLHIDNEKQCNWMDSLVFLNLSESGLTNSVFGCLPINLQILDLSK 453

  Fly   210 NYSSSNNITVGQSVQI---------LSDEDQRCVQMGQPLPRYNACVLYAEADIDH--ATEIMNN 263
            |..||..|.|...|.:         |:|... |..:|.     |..||..:.:..:  ..|.:.|
Frog   454 NQISSIPIEVKNFVSLKELHLASNRLTDIPD-CHNIGN-----NLGVLKVDENFINLPPKEFLQN 512

  Fly   264 LESERY------------NLRLFLRHRDMLMGVPF----------------EHV-----QLSHFM 295
            .|..:|            :||.|::     |||.|                |:|     |..|..
Frog   513 CEYVQYLSAGQNPFQCNCDLREFVK-----MGVMFPKRLVGWPESYKCADPENVKGIFLQDFHLS 572

  Fly   296 ATRCN---HLIVVLTEEFLRS 313
            ...||   .|.|||...|:.|
Frog   573 EISCNTSLFLGVVLGTIFVVS 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myd88	NP_001260821.1	DD	90..172	CDD:301326	15/87 (17%)
Myd88	NP_001260821.1	TIR_2	242..375	CDD:304906	26/110 (24%)
XB5889249	XP_017950848.2	leucine-rich repeat	48..70	CDD:275378
		PLN00113	50..>484	CDD:215061	45/224 (20%)
		LRR_8	70..129	CDD:404697
		leucine-rich repeat	71..94	CDD:275378
		leucine-rich repeat	95..118	CDD:275378
		leucine-rich repeat	119..143	CDD:275378
		LRR	<398..>524	CDD:227223	29/142 (20%)
		leucine-rich repeat	400..423	CDD:275380	6/33 (18%)
		leucine-rich repeat	424..445	CDD:275378	6/20 (30%)
		leucine-rich repeat	446..468	CDD:275378	5/21 (24%)
		leucine-rich repeat	469..491	CDD:275378	4/27 (15%)
		leucine-rich repeat	492..515	CDD:275378	4/22 (18%)
		leucine-rich repeat	516..528	CDD:275378	1/11 (9%)
		LRRCT	524..576	CDD:214507	11/56 (20%)
		TIR	636..777	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910