DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myd88 and tlr2

DIOPT Version :9

Sequence 1:	NP_001260821.1	Gene:	Myd88 / 35956	FlyBaseID:	FBgn0033402	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	XP_002933537.2	Gene:	tlr2 / 100485771	XenbaseID:	XB-GENE-481145	Length:	780	Species:	Xenopus tropicalis

Alignment Length:	149	Identity:	35/149 - (23%)
Similarity:	65/149 - (43%)	Gaps:	23/149 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 YNACVLYAEADIDHATEIM-NNLESERYNLRLFLRHRDMLMGV-----PFEHVQLSHFMATRCNH 301
            ||..|.|:|.|.:....:| ..||:....::|.|..||.:.|.     ..:.::.|:       .
Frog   635 YNGFVSYSERDSEWVENMMVPKLENAVPPMKLCLHKRDFVPGKWIIDNIIDAMEKSY-------K 692

  Fly   302 LIVVLTEEFLRSPENTYLVNFTQ-KIQIENHTRKIIPILY--------KTDMHIPQTLGIYTHIK 357
            .:.||:|.|:||....|.:.|:. ::..||:...|:.:|.        |....:.:.:...|:::
Frog   693 TVFVLSEHFVRSEWCKYELEFSHFRLFDENNDTAILILLEPIENETVPKRFCKLRKLMNTKTYLE 757

  Fly   358 YAGDSKLFN-FWDKLARSL 375
            :..|.:... |||.|..:|
Frog   758 WPTDEEQQEVFWDNLKTAL 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myd88	NP_001260821.1	DD	90..172	CDD:301326
Myd88	NP_001260821.1	TIR_2	242..375	CDD:304906	34/147 (23%)
tlr2	XP_002933537.2	internalin_A	55..>247	CDD:380193
		leucine-rich repeat	55..75	CDD:275378
		LRR_8	75..133	CDD:404697
		leucine-rich repeat	76..99	CDD:275378
		leucine-rich repeat	100..123	CDD:275378
		leucine-rich repeat	124..148	CDD:275378
		leucine-rich repeat	149..162	CDD:275378
		leucine-rich repeat	322..352	CDD:275378
		PRK15370	<353..>508	CDD:185268
		leucine-rich repeat	355..382	CDD:275380
		leucine-rich repeat	386..411	CDD:275380
		leucine-rich repeat	412..435	CDD:275380
		leucine-rich repeat	436..455	CDD:275380
		leucine-rich repeat	456..475	CDD:275380
		leucine-rich repeat	476..497	CDD:275380
		leucine-rich repeat	498..521	CDD:275380
		TIR	634..779	CDD:214587	35/149 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910