DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myd88 and il1rap

DIOPT Version :9

Sequence 1:	NP_001260821.1	Gene:	Myd88 / 35956	FlyBaseID:	FBgn0033402	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	XP_012818247.1	Gene:	il1rap / 100216065	XenbaseID:	XB-GENE-492428	Length:	690	Species:	Xenopus tropicalis

Alignment Length:	211	Identity:	46/211 - (21%)
Similarity:	83/211 - (39%)	Gaps:	56/211 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 YNACVLYAEADIDHATE-------IMNNLESERYNLRLFLRHRDMLMG-----VPFEHVQLSHFM 295
            |:..|.||.    :|.|       :...||:| :..:|.:..||.|.|     ..||.:|
Frog   405 YDVYVSYAR----NAEEEEFVLVTLRGVLENE-FGYKLCIFDRDSLPGGNTMEAVFEFIQ----- 459

  Fly   296 ATRCNHLIVVLTEEFLRSPENTYLVNFTQKIQIENH-TRKIIPILYK----TDMHIPQTLGIYTH 355
              |...:||||:.::| :.::..::.|...:..:|. ...:|.:.|:    |...|.:.......
Frog   460 --RSRRMIVVLSPDYL-TDKSISMLEFKLGMVCQNSICTSLIIVEYRPLQGTHTTIAKLKETIPF 521

  Fly   356 IKYAGDSKLFN---FWD--KLARSLHDLDAFSIY----------STRQVQ-----------TPSP 394
            :::.|:|...|   ||.  :||..|..|...|.:          |..|:|           |||.
Frog   522 VRWEGESSRRNNSKFWKALRLALPLRSLTTRSSWNESCSSQSDISLDQIQKKKRRLKGELVTPST 586

  Fly   395 VEESAPRVTTPSIRIQ 410
            ::.:..:.|....:::
Frog   587 IQSTKDKNTPQGSKVK 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myd88	NP_001260821.1	DD	90..172	CDD:301326
Myd88	NP_001260821.1	TIR_2	242..375	CDD:304906	36/153 (24%)
il1rap	XP_012818247.1	Ig	25..132	CDD:416386
		Ig strand A	26..29	CDD:409353
		Ig strand A'	34..38	CDD:409353
		Ig strand B	42..47	CDD:409353
		Ig strand C	67..71	CDD:409353
		Ig strand C'	80..82	CDD:409353
		Ig strand D	91..95	CDD:409353
		Ig strand E	97..101	CDD:409353
		Ig strand F	110..118	CDD:409353
		Ig strand G	121..132	CDD:409353
		Ig	145..235	CDD:416386
		Ig strand A	147..152	CDD:409353
		Ig strand A	147..152	CDD:409353
		Ig strand B	157..161	CDD:409353
		Ig strand B	157..161	CDD:409353
		Ig strand C	175..180	CDD:409353
		Ig strand C	175..180	CDD:409353
		Ig strand D	189..193	CDD:409353
		Ig strand D	189..193	CDD:409353
		Ig strand E	195..200	CDD:409353
		Ig strand E	195..200	CDD:409353
		Ig strand F	209..218	CDD:409353
		Ig strand F	209..218	CDD:409353
		Ig strand G	221..234	CDD:409353
		Ig strand G	221..234	CDD:409353
		Ig	243..349	CDD:416386
		Ig strand A	243..246	CDD:409353
		Ig strand A'	254..258	CDD:409353
		Ig strand B	260..269	CDD:409353
		Ig strand C	278..283	CDD:409353
		Ig strand C'	286..288	CDD:409353
		Ig strand D	296..304	CDD:409353
		Ig strand E	310..318	CDD:409353
		Ig strand F	329..335	CDD:409353
		Ig strand G	339..345	CDD:409353
		TIR	405..541	CDD:396246	34/148 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910