Protein Alignment Mad1 and Mad1l1

DIOPT Version :10

• Sequence 1: NP_610477.2
• Gene: Mad1 / 35954
• FlyBaseID: FBgn0026326
• Length: 730
• Species: Drosophila melanogaster
• Sequence 2: XP_063127720.1
• Gene: Mad1l1 / 680006
• RGDID: 1596881
• Length: 766
• Species: Rattus norvegicus
• Alignment Length: 738
• Identity: 205/738 - (27%)
• Similarity: 348/738 - (47%)
• Gaps: 102/738 - (13%)

  Fly    54 RSLN-------DTASSLNMPANDSMASL-----QNSKL--RTELIETKAIVIQLRNEIEKKSREH 104
            ||||       :.||.|::..:.| .||     ||.:|  |.|.|.:|:.:||:..|..:....|
  Rat    64 RSLNNFISQRMEGASGLDVSTSAS-GSLQKQYEQNMQLEERAEQIRSKSYLIQVEREKMQMELSH 127

  Fly   105 KEAILLAENKSTALKDQCDITSKKNLELQDDLKALRKRELVLKNEASRATAELNQL-RLKFDEST 168
            |.|.:..|..::......:....:|.||...::.|::||...: |..|...|.::| :...|.::
  Rat   128 KRARVELERAASTNARNYEREVDRNQELLARIRQLQEREAAAE-EKMREQLERHRLCKQSLDAAS 191

  Fly   169 LKLQKEKYLQKED----ARDVHLCINNELSEYRRIAQRADLELQSTRNELERLRQLNE--ELQAR 227
            .:|:     ::||    ||:....:...:||.:..|.  |.::|..|.|.|: ::|.|  |||.|
  Rat   192 QQLR-----EREDGLAAARETISSLKGRVSELQLSAM--DQKVQVKRLESEK-QELKEQLELQQR 248

  Fly   228 A-----SGFEQLRANHEKQTQSLKVANDRIQELEFEIQSYSDWKEVVKTSRERLASVPDLLAEVE 287
            .     ...::|:|:.|::|..    ..:|::||.::........|||:.:..|..:|.:..|::
  Rat   249 KWQEANQKIQELQASQEERTDQ----EQKIKDLEQKLCLQEQDAAVVKSMKSELLRLPRMERELK 309

  Fly   288 HLRSHNKHLNTLIGDKLLLEEQVYDYKTRLEREEGARAEAASLQVKLLHMEQELKEWVKVAQDHC 352
            .||..|.||..:.....||.|::...:.:|.|:|..:.....|:::...:..:|:.|.|:  |..
  Rat   310 RLREENTHLREMRETNGLLTEELEGLQRKLGRQEKMQEALVDLELEKEKLLAKLQSWEKL--DQT 372

  Fly   353 LANTLVSPMALRSRIEQLLKEDIIHVAEKTSSASDTKHLNTTIRDLEHKCAIYLKNIEDLNIGL- 416
            :...|.:|..| ||....|::..:.:.||.||      :.::.|.||.........:..:|..|
  Rat   373 MGLNLRTPEDL-SRFVIELQQRELALKEKNSS------ITSSARGLEKAQQQLQDEVRQVNAQLL 430

  Fly   417 ----KR--HKNFKERLQRKLITVSKERDFYKQLVENFDKDTTLSNAS---------VADMTQ--- 463
                ||  |:....|||::...::||||..:.::.::|.:.|.:..|         ..||.|
  Rat   431 EERKKRETHEALARRLQKRNALLTKERDGMRAILGSYDSELTQAEYSPQLTQRMWEAEDMVQKVH 495

  Fly   464 ----DMQVRVRMEVLERTVTGYKDMCATLEREIQSLRQQELVNEPAGEGYDSVKKELDTLRM--- 521
                :|:.::...:.|..|  .|....|||.|::.||.|   ...|...:...|:|:|.||:
  Rat   496 AHSSEMEAQLSQALEELGV--QKQRADTLEMELKMLRAQ---TSSAEASFPFCKEEVDALRLKVE 555

  Fly   522 ----ENDRLRRRKEELEMEMMHRCLRGDFNMKDFKVVHFSENPAAEAYESTKNMMEKLQAEIERL 582
                |..||.:.|:.|||:|....|:||:|....||:|.|.|||:.|.:..:...::||.|.|||
  Rat   556 ELEGERSRLEQEKQALEMQMERLTLQGDYNQSRTKVLHMSLNPASMARQRQREDHDRLQEECERL 620

  Fly   583 K------RRNKKLEDDNEQRLNETTSTGGMTLNFKEFNQLQAELESANGKMRKMRDCFKAAREEF 641
            :      .|...:..|.|...:..:|        ||..:|:.::|||..|.:::::.|:...:||
  Rat   621 RGLVHALERGGPIPADLEAASSLPSS--------KEVAELRKQVESAELKNQRLKEVFQTKIQEF 677

  Fly   642 RDVCYMLLGYRIDRIGANSNYRISSMFAEGPDDYLDISLN--ESNCLALLESPYSHTFNPPID-Q 703
            |.|||.|.||:|| :...|.||::|.:||...|.|.....  ..:.:.|||:.:|.:....|: .
  Rat   678 RKVCYTLTGYQID-VTTESQYRLTSRYAEHQTDCLIFKATGPSGSKMQLLETEFSRSVPELIELH 741

  Fly   704 QLAASNFPAFFSALTLELFQKAT 726
            .|...:.|||.||||:|||.:.|
  Rat   742 LLQQDSIPAFLSALTIELFSRQT 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mad1	NP_610477.2	MAD	80..726	CDD:461677	191/696 (27%)
Mad1l1	XP_063127720.1	None