Protein Alignment Mad1 and mad1l1

DIOPT Version :9

• Sequence 1: NP_610477.2
• Gene: Mad1 / 35954
• FlyBaseID: FBgn0026326
• Length: 730
• Species: Drosophila melanogaster
• Sequence 2: NP_001006927.1
• Gene: mad1l1 / 448774
• XenbaseID: XB-GENE-6258053
• Length: 718
• Species: Xenopus tropicalis
• Alignment Length: 715
• Identity: 185/715 - (25%)
• Similarity: 341/715 - (47%)
• Gaps: 67/715 - (9%)

  Fly    56 LNDTASSLNMPANDSMASLQNSKLRTELIETKAIVIQLRNEIEKKSRE-------HKEAILLAEN 113
            |..||.||. .:..:.||||....:..|:|.:|..|:.::.:.:..||       ||.|.:..|.
 Frog    25 LEGTAPSLG-TSTSTGASLQMQFQQRFLLEDQAAQIRSKSHLIQVEREKMQMELSHKRARIELEK 88

  Fly   114 KSTALKDQCDITSKKNLELQDDLKALRKRELVLKNEASRATAELNQLRLKFDESTLKLQKEKYLQ 178
            .::......:..:.:|.||...:|||.:||    |:......|.|:: :|..:.|::.|.:|.|:
 Frog    89 AASTNAKNYEREADRNQELITRIKALEERE----NDFQNKLQEQNEM-IKSYKKTIEAQSKKLLE 148

  Fly   179 KEDARDVHLCINNELS---------EYRRIAQRADLELQSTRNELERLRQLNEELQARASGFEQL 234
            |||....   :|..:|         :::.:.|...::.|.|..: |...||....:......|::
 Frog   149 KEDKLSE---LNENISVLKGKATELQWKIMNQEMQIKTQETEKQ-EMTEQLEIHRKKLQESNEKM 209

  Fly   235 RANHEKQTQSLKVAND-RIQELEFEIQSYSDWKEVVKTSRERLASVPDLLAEVEHLRSHNKHLNT 298
            :|.||.|.|:  |.|: :|:.||.::.:......:||:.:..||.:|.|..|::.||..|.:...
 Frog   210 QALHELQAQN--VDNEQKIKSLEQKLSAQEQDAAIVKSMKSDLAKLPKLERELQQLRDENAYHRE 272

  Fly   299 LIGDKLLLEEQVYDYKTRLEREEGARAEAASLQVKLLHMEQELKEWVKVAQDHCLANTLVSPMAL 363
            :..:..||:|:|...:...||....:.:...|:::...:.::||.|..:  :|.....:.:|..|
 Frog   273 MKENNALLKEEVEGLRRAAERFNKMKEDLVGLEIEKEQLLKKLKLWESL--EHTTGLNIRTPDDL 335

  Fly   364 RSRIEQLLKEDIIHVAEKTSSASDTKHLNTTIRDL-EHKCAIYLKNIEDLNIGLKRHKN---FKE 424
            ..:|..:.:.::....|..:..:..:.|.|:.:.| |....:....:|:    .||.::   |..
 Frog   336 SRQIIAVQQRELKLKEENMTIQNSARMLETSRQQLREELLKVQAGFLEE----KKRREHQEAFVR 396

  Fly   425 RLQRKLITVSKERDFYKQLVENFDKDTTLSNAS----------------VADMTQDMQVRVRMEV 473
            |||::::.::||||..:.:::::|.:.|.:..|                |.|...:|:.:: .|.
 Frog   397 RLQKRVLLLTKERDGMRAILDSYDSELTPTEHSPQLSRRLREAEDMVQKVQDHNAEMETQL-SEA 460

  Fly   474 LERTVTGYKDMCATLEREIQSLRQQELVNEP----AGEGYDSVKKELDTLRMENDRLRRRKEELE 534
            ||.|.. .|.....|..|::.|:.|...::.    ..|..::::.:::.|..|..||....:.||
 Frog   461 LEETGI-QKQKSDLLMAELKVLKSQMGSSDQNISFTNEAMNTLRLKIEELEAERGRLEEENKILE 524

  Fly   535 MEMMHRCLRGDFNMKDFKVVHFSENPAAEAYESTKNMMEKLQAEIERLKRRNKKLEDDNEQRLNE 599
            |.:....|:|.::....||:|...||:::|.:.....:.:||.|..:|:...:.||  ...::.:
 Frog   525 MRLERLNLQGCYDPSKTKVIHLGLNPSSQAKQQRAETVRQLQEECSKLRELVRILE--GGAQIPD 587

  Fly   600 TTSTGGMTLNFKEFNQLQAELESANGKMRKMRDCFKAAREEFRDVCYMLLGYRIDRIGANSNYRI 664
            .....|...:.:|..:|:.:||||..|.:::|:.|:....|||..||||.||||| |...:.||:
 Frog   588 KLEAAGSVQSSQELTELKKQLESAELKNQRLREVFQTKIHEFRTACYMLTGYRID-ITTENQYRL 651

  Fly   665 SSMFAEGPDDYL--DISLNESNCLALLESPYSHTFNPPIDQQLAASN-FPAFFSALTLELFQKAT 726
            :||:||..:|.|  ..|.:....:.|||:.:|.|....||..|...| .|||.||:||:||.:.|
 Frog   652 TSMYAEQKEDNLLFKASGSSGGKMQLLETDFSLTLRDFIDLHLHHQNSIPAFLSAVTLDLFSRQT 716

  Fly   727  726
             Frog   717  716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mad1	NP_610477.2	MAD	80..726	CDD:283261	175/689 (25%)
mad1l1	NP_001006927.1	MAD	55..716	CDD:368498	173/682 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	200	1.000	Domainoid score	I2974
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74500
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3653
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D483557at33208
OrthoFinder	1	1.000	-	-		FOG0004279
OrthoInspector	1	1.000	-	-		oto103468
Panther	1	1.100	-	-	LDO	PTHR23168
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160