Protein Alignment Mad1 and Mad1l1

DIOPT Version :10

• Sequence 1: NP_610477.2
• Gene: Mad1 / 35954
• FlyBaseID: FBgn0026326
• Length: 730
• Species: Drosophila melanogaster
• Sequence 2: XP_036020731.1
• Gene: Mad1l1 / 17120
• MGIID: 1341857
• Length: 725
• Species: Mus musculus
• Alignment Length: 710
• Identity: 185/710 - (26%)
• Similarity: 321/710 - (45%)
• Gaps: 119/710 - (16%)

  Fly    54 RSLN-------DTASSLNMPANDSMASLQNS-------KLRTELIETKAIVIQLRNEIEKKSREH 104
            ||||       :..|.|::..:.| .|||..       :.|.|.|.:|:.:||:..|..:....|
Mouse    15 RSLNNFISQRMEGTSGLDVSTSAS-GSLQKQYEYHMQLEERAEQIRSKSYLIQVEREKMQMELSH 78

  Fly   105 KEAILLAENKSTALKDQCDITSKKNLELQDDLKALRKREL---VLKNEASRATAE---LNQL-RL 162
            |.|.:..|..::        |:.:|.|.:.|    |.:||   :.:.:...||||   ..|| |.
Mouse    79 KRARVELERAAS--------TNARNYEREVD----RNQELLARIRQLQECEATAEEKMREQLERH 131

  Fly   163 KFDESTLKLQKEKYLQKED----ARDVHLCINNELSEYRRIA-------QRADLELQSTRNELE- 215
            :..:..|....::..::||    ||::...:...:||.:..|       :|.:.|.|..:.:||
Mouse   132 RLCKQNLDAVSQQLREQEDSLASAREMISSLKGRVSELQLSAMDQKVQVKRLESEKQELKEQLEL 196

  Fly   216 ---RLRQLNEELQARASGFEQLRANHEKQTQSLKVANDRIQELEFEIQSYSDWKEVVKTSRERLA 277
               :.::.|:::|...:..:: ||.||:          :|::||.::........|||:.:..|.
Mouse   197 QQRKWQEANQKIQELQASQDE-RAEHEQ----------KIKDLEQKLCLQEQDAAVVKSMKSELM 250

  Fly   278 SVPDLLAEVEHLRSHNKHLNTLIGDKLLLEEQVYDYKTRLEREEGARAEAASLQVKLLHMEQELK 342
            .:|.:..|::.|...|.||..:.....||.|::...:.:|.|:|..:.....|:::...:..:|:
Mouse   251 RMPRMERELKRLHEENTHLREMKETNGLLTEELEGLQRKLSRQEKMQEALVDLELEKEKLLAKLQ 315

  Fly   343 EWVKVAQDHCLANTLVSPMALRSRIEQLLKEDIIHVAEK----TSSASDTKHLNTTIRDLEHKCA 403
            .|..:  |..:...|.:|..| ||....|::..:.:.||    ||||...:.:...::|     .
Mouse   316 SWENL--DQTMGLNLRTPEDL-SRFVVELQQRELTLKEKNNSITSSARGLEKVQQQLQD-----E 372

  Fly   404 IYLKNIEDLNIGLKR--HKNFKERLQRKLITVSKERDFYKQLVENFDKDTTLSNAS--------- 457
            :...|.:.|....||  |:....|||::...::||||..:.::.::|.:.|.:..|
Mouse   373 VRQANAQLLEERKKRETHEALARRLQKRNALLTKERDGMRAILGSYDSELTQTEYSTQLTQRLWE 437

  Fly   458 VADMTQ-------DMQVRVRMEVLERTVTGYKDMCATLEREIQSLRQQELVNEPAGEGYDSVKKE 515
            ..||.|       :|:.::...:.|..|  .|....|||.|::.|:.|   ...|...:...|:|
Mouse   438 AEDMVQKVHAHSSEMEAQLSQALEELGV--QKQRADTLEMELKMLKAQ---TSSAESSFSFCKEE 497

  Fly   516 LDTLRM-------ENDRLRRRKEELEMEMMHRCLRGDFNMKDFKVVHFSENPAAEAYESTKNMME 573
            :|.||:       |..||.:.|:.|||:|....|:||:|....||:|.|.||.:.|.:......:
Mouse   498 VDALRLKVEELEGERSRLEQEKQVLEMQMEKLTLQGDYNQSRTKVLHMSLNPISMARQRQHEDHD 562

  Fly   574 KLQAEIERLK------RRNKKLEDDNEQRLNETTSTGGMTLNFKEFNQLQAELESANGKMRKMRD 632
            :||.|.|||:      .|...:..|.|...:..:|        ||..:|:.::|||..|.:::::
Mouse   563 RLQEECERLRGLVHALERGGPIPADLEAASSLPSS--------KEVAELRKQVESAELKNQRLKE 619

  Fly   633 CFKAAREEFRDVCYMLLGYRIDRIGANSNYRISSMFAEGPDDYLDISLNESNCLALLESP 692
            .|:...:|||.|||.|.||:|| :...|.||::|.:||...|.|  .....|.|.|..||
Mouse   620 VFQTKIQEFRKVCYTLTGYQID-VTTESQYRLTSRYAEHQTDCL--IFKGKNQLELQSSP 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mad1	NP_610477.2	MAD	80..726	CDD:461677	175/670 (26%)
Mad1l1	XP_036020731.1	MAD	54..665	CDD:461677	170/657 (26%)