Protein Alignment Mad1 and Mad1

DIOPT Version :10

• Sequence 1: NP_610477.2
• Gene: Mad1 / 35954
• FlyBaseID: FBgn0026326
• Length: 730
• Species: Drosophila melanogaster
• Sequence 2: XP_316663.5
• Gene: Mad1 / 1277219
• VectorBaseID: AGAMI1_013396
• Length: 757
• Species: Anopheles gambiae
• Alignment Length: 739
• Identity: 243/739 - (32%)
• Similarity: 421/739 - (56%)
• Gaps: 35/739 - (4%)

  Fly    18 SITHSAPKKLLFNRLSASFDLGVSPNKRRRERESPER-------------SLNDTASSLNMPAND 69
            |.|.....:|.|.. ||||:|  |..|||......:|             |.:.||:........
Mosquito    21 SSTAIGSSRLSFEN-SASFEL--SRKKRRISGPGCDRTTDTMYEANVSGDSFSTTATGYTTTTQV 82

  Fly    70 SMASLQNSKLRTELIETKAIVIQLRNEIEKKSREHKEAILLAENKSTALKDQCDITSKKNLELQD 134
            :.:..::.:::.:|||.::.:..|:.|||..:.|.....|..::|.::|:.:...:.:|..:|:.
Mosquito    83 AQSPWESRRIKADLIEARSRITFLKKEIEHLNTEMATTQLRNQHKISSLEKELGFSGQKVTDLEK 147

  Fly   135 DLKALRKRELVLKNEASRATAELNQLRLKFDESTLKLQK--EKYLQKEDARDVHLCINNELSEYR 197
            .|:.:||||.|.|.:.::...:|.||:.:.|....:|::  ::..||.|:....|  |.|:.:.
Mosquito   148 HLQLVRKREHVAKQDLNKVRTQLQQLKTEADGRQFELRQALQRLEQKYDSDTGEL--NTEIRDL- 209

  Fly   198 RIAQRADLELQST--RNELERLRQLNEELQARASGFEQLRANHEKQTQSLKVANDRIQELEFEIQ 260
             ..|..|||.|.|  ::||:..|::|:.||::|..::|.:...|.....|..|..|::.||:|:.
Mosquito   210 -TTQVNDLEQQLTLAQDELDTTREINDTLQSKADAYDQTKRELEATQDRLAEAESRVKTLEYEVG 273

  Fly   261 SYSDWKEVVKTSRERLASVPDLLAEVEHLRSHNKHLNTLIGDKLLLEEQVYDYKTRLEREEGARA 325
            ||.|||.:.|.|.:|||:..::..|...|:...|:|.:||||||||||||...:.||:..|...|
Mosquito   274 SYEDWKSLSKVSADRLANTTEIEKENVRLKDQLKNLQSLIGDKLLLEEQVASSQARLKDLEQKDA 338

  Fly   326 EAASLQVKLLHMEQELKEWVKVAQDHCLANTLVSPMALRSRIEQLLKEDIIHVAEKTSSASDTKH 390
            .:|:|:|::..:|:||.||.::.:|:....:|||...:|:||||:|::|::...|::|..::...
Mosquito   339 LSAALEVRVKELERELVEWRQLGKDYTPKESLVSAKTMRNRIEQILQKDLVLANEQSSVQTEKHQ 403

  Fly   391 LNTTIRDLEHKCAIYLKNIEDLNIGLKRHKNFKERLQRKLITVSKERDFYKQLVENFDKDTTLSN 455
            :...|.:|:.:.|:....:.|.....:..::...|.|:||..|:.|||:.|||:|:::.|.|:|:
Mosquito   404 IQGRIEELQSENALLNGRLADYKRAQEGLQSIVHRAQKKLNLVTGERDYLKQLLESYENDLTISH 468

  Fly   456 ASVADMTQDMQVRVRMEVLERTVTGYKDMCATLEREIQSLR-QQELVNEPAGEGYDSVKKELDTL 519
            :.|.......|:|.|:|:||:|:|||||:|...|.::|:.: ..::......|.|:.::||:|.|
Mosquito   469 SVVGSEADKKQLRARIEMLEKTLTGYKDLCQKQEADLQANKVLPDISFVLTSEQYEKLRKEIDEL 533

  Fly   520 RMENDRLRRRKEELEMEMMHRCLRGDFN----MKDFKVVHFSENPAAEAYESTKNMMEKLQAEIE 580
            |:||:||:|||:|||:|:.:|.||...|    .:..|:|.:..:||.|...:..|...||.||||
Mosquito   534 RLENERLKRRKDELEVEVENRTLRAQINRPCPTQTTKLVRYINSPATEDIVAEHNTKLKLMAEIE 598

  Fly   581 RLKRRNKKLEDDNE---QRLNETTSTGGMTLNFKEFNQLQAELESANGKMRKMRDCFKAAREEFR 642
            |||...::|::.|:   :.|:.|..||.||:..||...|:.:|:....|..:.::.::.:.|:||
Mosquito   599 RLKLHIQRLQETNQDLTECLHNTDETGNMTMKIKESVDLRMQLKELQAKYDQRKELYQQSSEDFR 663

  Fly   643 DVCYMLLGYRIDRIGANSNYRISSMFAEGPDDYLDISL-NESNCLALLESPYSHTFNPPIDQQLA 706
            .|..:|.|::|||| :.|.:::.|.:||.||:||:.:| .:.:.|.||||.|:.:....::.|..
Mosquito   664 TVVNLLFGFKIDRI-SGSYFQLRSQYAESPDEYLNFALAPDGSVLTLLESDYAASLRDLVETQFK 727

  Fly   707 ASN-FPAFFSALTLELFQKATVTM 729
            ..| .|.|.|:||||||.:.|:|:
Mosquito   728 THNSVPVFLSSLTLELFNRTTMTV 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mad1	NP_610477.2	MAD	80..726	CDD:461677	224/659 (34%)
Mad1	XP_316663.5	None