Protein Alignment Cog6 and COG6

DIOPT Version :9

• Sequence 1: NP_724783.1
• Gene: Cog6 / 35953
• FlyBaseID: FBgn0033401
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_014357.1
• Gene: COG6 / 855687
• SGDID: S000004986
• Length: 839
• Species: Saccharomyces cerevisiae
• Alignment Length: 686
• Identity: 135/686 - (19%)
• Similarity: 266/686 - (38%)
• Gaps: 150/686 - (21%)

  Fly     4 TQEKPEELDRIQKRVNKILEARLESDKDTLDAL--SGLSTFFTENTLQN---------------- 50
            |..:|:.||     ::|::.....|:|:|.:.:  :.||......||.|
Yeast   114 TNYEPKNLD-----LSKLVSPSSGSNKNTTNLVLSNKLSKILNNYTLINYQATVQLRKSLKVLEE 173

  Fly    51 ----------------------RRNLRSQIEHRSVGINENFLKAFRQVKLSLDAVCEDLDTMATS 93
                                  ||.||:.:|.:.:..:...|:.|:.:...:..:...::.:..:
Yeast   174 NKERLSLDEQKLMNPEYVGTLARRALRTDLESQLLKEHITVLEEFKPIIRRIKRLSSSVEKIQRT 238

  Fly    94 VETMKSDLETSKALTKDLIKQTNTMQR-ERDRLEVHKQIAQAFLARFQLSGAEHQLLYGAAKDAP 157
            .|.:.|: ||::..|.:::.|.....| :.::|::.|:|..:...||.|:..|..::.....|
Yeast   239 SEKLLSN-ETNEVPTNNVVLQEIDQYRLKAEQLKLKKKILLSIRDRFTLNQVEDDVITNGTID-- 300

  Fly   158 IVADFFRVLDRVQSIHADCRLLMQCGYQTAAIDIMEEMTLHQEGALERLYRWTQNHCRSLEN--- 219
              ..||.|:.:|.:|..:...|:......|...::..:....|...::::.:..:...|.|:
Yeast   301 --NIFFEVVKKVINIKDESSFLLTLPNLNAGNALIMGVNEILEKTNKKIFNYLIDFLYSFESSSN 363

  Fly   220 --NEIGPLIVEAMSRLQDRPV-------LFKYVIDEYAIARRAVLVRQFIEALTEGGPGGNPKPI 275
              |:.|....|:::..:...|       ||..::......|...::.:|:........  ..|||
Yeast   364 LLNDHGTTEQESLNIFRKSLVFLSSDLELFNELLKRVTTLRSKSILDEFLSQFDMNST--TSKPI 426

  Fly   276 ELHAHDPKRYIGDMFAWLHQSIPTEKENLSLLFKKCDKQD-------ISDQLQN----------A 323
            .|.||||.|||||:.|.:|..|..|.:.:..||   |.||       ||...||          .
Yeast   427 ILSAHDPIRYIGDVLASVHSIIANEADFVKSLF---DFQDEDLKDTPISILQQNKTFLKGIDNKL 488

  Fly   324 LGYIADGVCHPLKVRVETILQAEKDTIVLFTISNLLRFYQQIMRQ--VVQGGSLEECLVELQKSS 386
            |..|...:.:..::|:|.|::.|::.|:.|.|..||:.|:.:..:  :....|:...|..|:..|
Yeast   489 LNDIIQSLSNSCRIRIEQIVRFEENPIINFEIVRLLKLYRVMFERKGIQDDSSIINNLKSLEDIS 553

  Fly   387 EQIYLGALAAQVRSVLQRPSGGSGLALEPPQRDLVPPPSVARLLNMLKEILSV---ATMVDGRQA 448
            :...:|.....::..:...:..|       ..||:||..::..:|.|.|:..:   ....:..::
Yeast   554 KNRIIGYYEDYMKQTVMAETKNS-------SDDLLPPEWLSEYMNKLVELFEIYEKTHAAEDEES 611

  Fly   449 DITKIVSC----------VIDPLLQSVQES----------AAHLPTVDMGVYLLNCLHHMQSSLA 493
            :..|::|.          :.|.||:.:|.|          .|.|.|::     :||...::|.|.
Yeast   612 EDNKLLSSKNLQTIVEQPIKDVLLKQLQTSFPLAKKNEKEKASLLTIE-----INCFDLIKSRLQ 671

  Fly   494 VYEYM---------------DERVERLQAQSDAQLDTLTSEQASSLVANLNLGPIYAILQSNQSK 543
            .:|.:               |:..|..:.....|:..|.......|.:||    :..|...:..|
Yeast   672 PFEGLFAQDDDSRKITIWVCDKLKEYTKQMLTLQIKFLFENTGLDLYSNL----VNMIFPVDSVK 732

  Fly   544 IETNLLKIFMSKMDAFLELPDVLLLPQVQLIMSSSH 579
            .|.:        .|.:|.|.|..|: ::.::..:.|
Yeast   733 DELD--------YDMYLALRDNSLM-ELDMVRKNVH 759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cog6	NP_724783.1	COG6	47..627	CDD:215018	125/641 (20%)
COG6	NP_014357.1	COG6	195..834	CDD:215018	122/600 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344872
Domainoid	1	1.000	76	1.000	Domainoid score	I2111
eggNOG	1	0.900	-	-		E1_KOG3758
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	76	1.000	Inparanoid score	I1647
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54363
OrthoFinder	1	1.000	-	-		FOG0005102
OrthoInspector	1	1.000	-	-		oto100086
orthoMCL	1	0.900	-	-		OOG6_102906
Panther	1	1.100	-	-	LDO	PTHR21506
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R222
SonicParanoid	1	1.000	-	-		X4130
TreeFam	0	0.000	Not matched by this tool.
	13	12.830