Protein Alignment Cog6 and COG6

DIOPT Version :9

• Sequence 1: NP_724783.1
• Gene: Cog6 / 35953
• FlyBaseID: FBgn0033401
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: XP_011533470.1
• Gene: COG6 / 57511
• HGNCID: 18621
• Length: 702
• Species: Homo sapiens
• Alignment Length: 678
• Identity: 267/678 - (39%)
• Similarity: 413/678 - (60%)
• Gaps: 73/678 - (10%)

  Fly    14 IQKRVNKILEARLESDKDTLDALSGLSTFFTENTLQNRRNLRSQIEHRSVGINENFLKAFRQVKL 78
            :.::::||||.||::||:.|:||..|||||.||:|:.|||||..||.:|:.|||.|:..|::||.
Human    35 LSRKLHKILETRLDNDKEMLEALKALSTFFVENSLRTRRNLRGDIERKSLAINEEFVSIFKEVKE 99

  Fly    79 SLDAVCEDLDTMATSVETMKSDLETSKALTKDLIKQTNTMQRERDRLEVHKQIAQAFLARFQLSG 143
            .|:::.||:..|:...:.|.|.|:.:|..|:|||.:|..:|.|..:||:..|:|.|||::|||:.
Human   100 ELESISEDVQAMSNCCQDMTSRLQAAKEQTQDLIVKTTKLQSESQKLEIRAQVADAFLSKFQLTS 164

  Fly   144 AEHQLLYGAAKDAPIVADFFRVLDRVQSIHADCRLLMQCGYQTAAIDIMEEMTLHQEGALERLYR 208
            .|..||.| .::.||..|||:.|.||:.||.|.::|::...|||.::|||:|.|.||.|.|||||
Human   165 DEMSLLRG-TREGPITEDFFKALGRVKQIHNDVKVLLRTNQQTAGLEIMEQMALLQETAYERLYR 228

  Fly   209 WTQNHCRSL--ENNEIGPLIVEAMSRLQDRPVLFKYVIDEYAIARRAVLVRQFIEALTEGGPGGN 271
            |.|:.||:|  |:.::.|::.:||..|||||||:||.:||:..|||:.:||.||:|||.|||||.
Human   229 WAQSECRTLTQESCDVSPVLTQAMEALQDRPVLYKYTLDEFGTARRSTVVRGFIDALTRGGPGGT 293

  Fly   272 PKPIELHAHDPKRYIGDMFAWLHQSIPTEKENLSLLFKKCDKQDISDQLQNALGYIADGVCHPLK 336
            |:|||:|:|||.||:|||.|||||:..:|||:|..|.|....|.:.:.:|..:|:|.:|||.|||
Human   294 PRPIEMHSHDPLRYVGDMLAWLHQATASEKEHLEALLKHVTTQGVEENIQEVVGHITEGVCRPLK 358

  Fly   337 VRVETILQAEKDTIVLFTISNLLRFYQQIMRQVVQGGSLEECLV---ELQKSSEQIYLGALAAQV 398
            ||:|.::.||...::|:.|||||:||...:..:| |.|....|.   |:...|::|:..:|:...
Human   359 VRIEQVIVAEPGAVLLYKISNLLKFYHHTISGIV-GNSATALLTTIEEMHLLSKKIFFNSLSLHA 422

  Fly   399 RSVLQRPSGGSGLALEPPQRDLVPPPSVARLLNMLKEIL----SVATMVDGRQADITKIVSCVID 459
            ..::.:      :.|.||  ||.|..::.:.|.:|:|:|    |....:|.||||..:::|||:|
Human   423 SKLMDK------VELPPP--DLGPSSALNQTLMLLREVLASHDSSVVPLDARQADFVQVLSCVLD 479

  Fly   460 PLLQSVQESAAHLPTVDMGVYLLNCLHHMQSSLAVYEYMDERVERLQAQSDAQLDTLTSEQASSL 524
            ||||....||::|.|.||..:::|.|:.|:::||::|:.|.|:|.||.|.:|.||||.:||||.:
Human   480 PLLQMCTVSASNLGTADMATFMVNSLYMMKTTLALFEFTDRRLEMLQFQIEAHLDTLINEQASYV 544

  Fly   525 VANLNLGPIYAILQ---------SNQSKIETNLLKIFMSKMDAFLELPDVLLLPQVQLIMSS--- 577
            :..:.|..||..:|         :|...:::..||..|.:.|.:|..||.||:||:..::|:
Human   545 LTRVGLSYIYNTVQQHKPEQGSLANMPNLDSVTLKAAMVQFDRYLSAPDNLLIPQLNFLLSATVK 609

  Fly   578 ---------------------------------SH---------RAAVQKRSFNVIVAIYKQIYE 600
                                             :|         |..:.|:|..::...|.::|.
Human   610 PSADWMEPAPLTVNLLHSVFQLTCQSPVETPSQTHPEIMLYQLTREQIVKQSTELVCRAYGEVYA 674

  Fly   601 RVHDPANGFEQPEQLLHRTPEQVAHILT 628
            .|.:|.|.::.||.:|||:|:||..:|:
Human   675 AVMNPINEYKDPENILHRSPQQVQTLLS 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cog6	NP_724783.1	COG6	47..627	CDD:215018	248/642 (39%)
COG6	XP_011533470.1	COG6	56..697	CDD:283957	255/650 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152768
Domainoid	1	1.000	495	1.000	Domainoid score	I359
eggNOG	1	0.900	-	-		E1_KOG3758
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10802
Inparanoid	1	1.050	517	1.000	Inparanoid score	I1287
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54363
OrthoDB	1	1.010	-	-		D1370285at2759
OrthoFinder	1	1.000	-	-		FOG0005102
OrthoInspector	1	1.000	-	-		oto91083
orthoMCL	1	0.900	-	-		OOG6_102906
Panther	1	1.100	-	-	LDO	PTHR21506
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R222
SonicParanoid	1	1.000	-	-		X4130
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800