DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pkn and RPS6KA4

DIOPT Version :10

Sequence 1:NP_001097237.1 Gene:Pkn / 35950 FlyBaseID:FBgn0020621 Length:1501 Species:Drosophila melanogaster
Sequence 2:NP_003933.1 Gene:RPS6KA4 / 8986 HGNCID:10433 Length:772 Species:Homo sapiens


Alignment Length:341 Identity:129/341 - (37%)
Similarity:205/341 - (60%) Gaps:16/341 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly  1169 LSMDNFRLLSVLGRGHFGKVILSQLRSNN---QYYAIKALKKGDIIARDEV-ESLLSEKRIFEVA 1229
            :|::||.||.|||.|.:|||.|.:....:   :.||:|.|:|..::.|.:. |...:|:.:.|:.
Human    28 VSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELV 92

  Fly  1230 NAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIH-TDVFLEPRAVFYAACVVLGLQYLHEN 1293
            .  :.||||.|:..|||:..:..:::|.:||::..|:: ...|.|.....|...:||.|::||:.
Human    93 R--QAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKL 155

  Fly  1294 KIIYRDLKLDNLLLDTEGYVKIADFGLCKEGM-GFGDRTGTFCGTPEFLAPEVL-TETSYTRAVD 1356
            .||||||||:|:|||:||::.:.||||.||.: ...:||.:||||.|::|||:: ::|.:.:|||
Human   156 GIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVD 220

  Fly  1357 WWGLGVLIFEMLVGESPFPGDDEE----EVFDSIVNDEVRYPRFLSLEAIAVMRRLLRKNPERRL 1417
            ||.||:|:||:|.|.|||..:.|.    ||...|:.....:|..:...|..:::|||.|:|::||
Human   221 WWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRL 285

  Fly  1418 GSSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLTPPKEPRH 1482
            |:..:.|::|:...||:.:.|..|..||:..||.|.|....||.||.||||..:...:||..|  
Human   286 GAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSP-- 348

  Fly  1483 LTEEEQLLFQDFSYTA 1498
             ...:..:||.:|:.|
Human   349 -PPGDPRIFQGYSFVA 363

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PknNP_001097237.1 HR1_PKN_1 131..194 CDD:212012
HR1_PKN_2 243..309 CDD:212013
HR1_PKN_3 340..414 CDD:212015
C2 530..611 CDD:472691
STKc_PKN 1174..1499 CDD:270741 127/336 (38%)
RPS6KA4NP_003933.1 STKc_MSK2_N 32..364 CDD:270765 128/337 (38%)
Protein Kinases, catalytic domain 404..714 CDD:473864
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..696
Required for nuclear targeting and association with MAPK14 725..772
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 728..772
Blue background indicates that the domain is not in the aligned region.

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