Protein Alignment Pkn and YPK1

DIOPT Version :10

• Sequence 1: NP_001097237.1
• Gene: Pkn / 35950
• FlyBaseID: FBgn0020621
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_012796.1
• Gene: YPK1 / 853733
• SGDID: S000001609
• Length: 680
• Species: Saccharomyces cerevisiae
• Alignment Length: 573
• Identity: 172/573 - (30%)
• Similarity: 283/573 - (49%)
• Gaps: 83/573 - (14%)

  Fly   965 PEPPSAVEQQLHRPVLILPPVVLLGGREEDRSVPPSPLVEYPEDDD---EYLYRGSNENLGTRLH 1026
            |.|.::.||.|::        :|..|      ||| |..|..::.|   ..|.|...:|.|....
Yeast   133 PFPITSSEQILNK--------LLASG------VPP-PHKEISKEVDALIAQLSRVQIKNQGPADE 182

  Fly  1027 SSHSSSAGDRFCVEVIPQLGK------LY--------VGSSQQQYAQQSSPIIQEPATPTIYGN- 1076
            ...||.:..:|....|...|.      ||        |.:.:.:|...:.|...:.:|..:...
Yeast   183 DLISSESAAKFIPSTIMLPGSSTLNPLLYFTIEFDNTVATIEAEYGTIAKPGFNKISTFDVTRKL 247

  Fly  1077 -----SAAAGAPQFPQPAQRQEKQPPQQ--------------QPIYANQYELNV---AKAAAAAS 1119
                 ...|..|....|::..:::...|              |.|:.:.:.|.:   ..:||:..
Yeast   248 PYLKIDVFARIPSILLPSKTWQQEMGLQDEKLQTIFDKINSNQDIHLDSFHLPINLSFDSAASIR 312

  Fly  1120 VYSPSSSTTSNSNQQQQQQRRNVARGLQYRESGGLETGRAGKQPPNAGMLSMDNFRLLSVLGRGH 1184
            :|:....|..|.     ..:.|::  :.|:.|         :..|    ||:|:|.||.|:|:|.
Yeast   313 LYNHHWITLDNG-----LGKINIS--IDYKPS---------RNKP----LSIDDFDLLKVIGKGS 357

  Fly  1185 FGKVILSQLRSNNQYYAIKALKKGDIIARDEVESLLSEKRIFEVANAMRHPFLVNLYSCFQTEQH 1249
            ||||:..:.:...:.||:||::|..|:::.||...|:|:.:....:.   ||:|.|...||:.:.
Yeast   358 FGKVMQVRKKDTQKVYALKAIRKSYIVSKSEVTHTLAERTVLARVDC---PFIVPLKFSFQSPEK 419

  Fly  1250 VCFVMEYAAGGDLMMHIHTD-VFLEPRAVFYAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYV 1313
            :.||:.:..||:|..|:..: .|...||.||.|.::..|..||:..::|||||.:|:|||.:|::
Yeast   420 LYFVLAFINGGELFYHLQKEGRFDLSRARFYTAELLCALDNLHKLDVVYRDLKPENILLDYQGHI 484

  Fly  1314 KIADFGLCKEGMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDD 1378
            .:.||||||..|...|:|.|||||||:||||:|....||:|||||.||||::|||.|..|:..:|
Yeast   485 ALCDFGLCKLNMKDDDKTDTFCGTPEYLAPELLLGLGYTKAVDWWTLGVLLYEMLTGLPPYYDED 549

  Fly  1379 EEEVFDSIVNDEVRYPRFLSLEAIAVMRRLLRKNPERRLGSSERDAEDVKKQAFFRSIVWDDLLL 1443
            ..:::..|:.:.:.:|.....:|..::..||.::|.||||.:  .|::::...||..:.|..||:
Yeast   550 VPKMYKKILQEPLVFPDGFDRDAKDLLIGLLSRDPTRRLGYN--GADEIRNHPFFSQLSWKRLLM 612

  Fly  1444 RKVKPPFVPTINHLEDVSNFDEEFTSEKAQLTPPKEPRHLTEEEQLLFQDFSY 1496
            :...||:.|.:::..|.||||||||.||...:...|  :|:|..|..|..::|
Yeast   613 KGYIPPYKPAVSNSMDTSNFDEEFTREKPIDSVVDE--YLSESVQKQFGGWTY 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012
		HR1_PKN_2	243..309	CDD:212013
		HR1_PKN_3	340..414	CDD:212015
		C2	530..611	CDD:472691
		STKc_PKN	1174..1499	CDD:270741	125/324 (39%)
YPK1	NP_012796.1	YPK1_N_like	116..342	CDD:212165	44/243 (18%)
		Protein Kinases, catalytic domain	352..663	CDD:473864	121/317 (38%)