DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkn and prkcd

DIOPT Version :9

Sequence 1:	NP_001097237.1	Gene:	Pkn / 35950	FlyBaseID:	FBgn0020621	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	XP_002934267.1	Gene:	prkcd / 733756	XenbaseID:	XB-GENE-478663	Length:	683	Species:	Xenopus tropicalis

Alignment Length:	404	Identity:	172/404 - (42%)
Similarity:	250/404 - (61%)	Gaps:	39/404 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly  1114 AAAAASVYSPSSSTTSNSNQQQQQQRRNVA---------RGLQYRESGGLETGR--AGKQP-PNA 1166
            |.|...|...|||..|:|...      |:|         .||...::...:..|  .|..| |:.
Frog   287 AEALNQVSMKSSSRKSDSGLD------NIAIYQGVNPKTPGLPMPDATDNQYDRLWEGSSPHPHI 345

  Fly  1167 GM---LSMDNFRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVESLLSEKRIFEV 1228
            .:   |.:|||....|||:|.||||:|::|:...:|:|||||||..::..|:||..:.|||:  :
Frog   346 SLSSRLKIDNFVFHKVLGKGSFGKVLLAELKGKGEYFAIKALKKDVVLIDDDVECTMVEKRV--L 408

  Fly  1229 ANAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIHT----DVFLEPRAVFYAACVVLGLQY 1289
            |.|..:|||.::|..|||::|:.||||:..|||||.||..    |::   ||.|||:.::.|||:
Frog   409 ALAWENPFLTHIYCSFQTKEHLFFVMEFLNGGDLMFHIQDKGRFDLY---RATFYASEIICGLQF 470

  Fly  1290 LHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGD-RTGTFCGTPEFLAPEVLTETSYTR 1353
            ||...||||||||||::||.:|::||||||:|||.: :|| :..||||||:::|||:|....||.
Frog   471 LHSKGIIYRDLKLDNVMLDKDGHIKIADFGMCKENV-YGDNKASTFCGTPDYIAPEILQGLKYTF 534

  Fly  1354 AVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRRLLRKNPERRLG 1418
            :||||..|||::|||:|:|||.||||:|:|:||..|...|||:::.|:..::.||..:.|.:|||
Frog   535 SVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRQDTPHYPRWITKESKDILERLFEREPTKRLG 599

  Fly  1419 SSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLTPPKEPRHL 1483
            .    ..::|...||::|.|..|..|:::|||.|.:....|.||||.||.|||.:|:  ...::|
Frog   600 V----VGNIKVHPFFKTINWTALERRELEPPFKPKVKSPSDYSNFDREFLSEKPRLS--FSDKNL 658

  Fly  1484 TEE-EQLLFQDFSY 1496
            .:. :|..|..||:
Frog   659 IDSMDQSAFHGFSF 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012
		HR1_PKN_2	243..309	CDD:212013
		HR1_PKN_3	340..414	CDD:212015
		C2	530..611	CDD:301316
		STKc_PKN	1174..1499	CDD:270741	153/329 (47%)
		S_TKc	1174..1433	CDD:214567	127/263 (48%)
prkcd	XP_002934267.1	C1_1	158..207	CDD:365894
		C1_1	230..280	CDD:365894
		STKc_nPKC_delta	360..675	CDD:173710	152/325 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940