DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pkn and RPS6KA3

DIOPT Version :10

Sequence 1:NP_001097237.1 Gene:Pkn / 35950 FlyBaseID:FBgn0020621 Length:1501 Species:Drosophila melanogaster
Sequence 2:XP_011543857.1 Gene:RPS6KA3 / 6197 HGNCID:10432 Length:746 Species:Homo sapiens


Alignment Length:403 Identity:145/403 - (35%)
Similarity:214/403 - (53%) Gaps:44/403 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly  1119 SVYSPSSSTTSNSN-------------QQQQQQRRNVARGLQYRESGGLETGRAGKQPPNAGMLS 1170
            :|.|||.|..:...             |.::...:.:|  :.:....|.|     |..|:     
Human    14 AVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIA--ITHHVKEGHE-----KADPS----- 66

  Fly  1171 MDNFRLLSVLGRGHFGKVILSQLRSNN---QYYAIKALKKGDIIARDEVESLLSEKRIFEVANAM 1232
              .|.||.|||:|.||||.|.:..|.:   |.||:|.|||..:..||.|.:.:....:.||    
Human    67 --QFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEV---- 125

  Fly  1233 RHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIHTDV-FLEPRAVFYAACVVLGLQYLHENKII 1296
            .|||:|.|:..||||..:..::::..||||...:..:| |.|....||.|.:.|.|.:||...||
Human   126 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGII 190

  Fly  1297 YRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWWGLG 1361
            |||||.:|:|||.||::|:.||||.||.:....:..:||||.|::||||:....:|::.|||..|
Human   191 YRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFG 255

  Fly  1362 VLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRRLLRKNPERRL------GSS 1420
            ||:||||.|..||.|.|.:|....|:..::..|:|||.||.:::|.|.::||..||      |:.
Human   256 VLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLVNPFLIGAG 320

  Fly  1421 ERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLTPPKEPRHLTE 1485
            ....|::|:.:||.:|.|:.|..|::.|||.|.....||...||.|||::..:.:|...|   :.
Human   321 PDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPP---SA 382

  Fly  1486 EEQLLFQDFSYTA 1498
            ....||:.||:.|
Human   383 NAHQLFRGFSFVA 395

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PknNP_001097237.1 HR1_PKN_1 131..194 CDD:212012
HR1_PKN_2 243..309 CDD:212013
HR1_PKN_3 340..414 CDD:212015
C2 530..611 CDD:472691
STKc_PKN 1174..1499 CDD:270741 134/335 (40%)
RPS6KA3XP_011543857.1 STKc_RSK_N 72..394 CDD:270734 130/328 (40%)
STKc_RSK2_C 408..737 CDD:271078
Blue background indicates that the domain is not in the aligned region.

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