DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pkn and RPS6KA2

DIOPT Version :10

Sequence 1:NP_001097237.1 Gene:Pkn / 35950 FlyBaseID:FBgn0020621 Length:1501 Species:Drosophila melanogaster
Sequence 2:XP_006715612.1 Gene:RPS6KA2 / 6196 HGNCID:10431 Length:761 Species:Homo sapiens


Alignment Length:426 Identity:152/426 - (35%)
Similarity:224/426 - (52%) Gaps:54/426 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly  1108 ELNVAKAAAAA--SVYSPSSSTTSNSNQQQQQQRRNVARGL----------------QYRESG-- 1152
            :|::.|.|...  |||....|.:.:|:..:.:.....|.|:                |:.|.|  
Human     2 DLSMKKFAVRRFFSVYLRRKSRSKSSSLSRLEGLNRRAAGIKVVTIADCLHSREPETQHEEEGVV 66

  Fly  1153 -----------GLETGRAGKQPPNAGMLSMDNFRLLSVLGRGHFGKVIL-SQLRSNN--QYYAIK 1203
                       |.|     |..|:       .|.||.|||:|.:|||.| .:::.::  |.||:|
Human    67 KEIDISHHVKEGFE-----KADPS-------QFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMK 119

  Fly  1204 ALKKGDIIARDEVESLLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIHT 1268
            .|||..:..||.|.|.:....:.||    .|||:|.|:..||||..:..::::..||||...:..
Human   120 VLKKATLKVRDRVRSKMERDILAEV----NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK 180

  Fly  1269 DV-FLEPRAVFYAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTG 1332
            :| |.|....||.|.:.|.|.:||...|||||||.:|:|||.||::||.||||.||.:....|..
Human   181 EVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAY 245

  Fly  1333 TFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFL 1397
            :||||.|::||||:....:|::.|||..|||:||||.|..||.|.|.:|....|:..::..|:||
Human   246 SFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFL 310

  Fly  1398 SLEAIAVMRRLLRKNPERRLGSSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSN 1462
            |.||.:::|.|.::||..|||:.....|::|:..||.:|.|:.|..:::||||.|.:...||..:
Human   311 SGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFH 375

  Fly  1463 FDEEFTSEKAQLTPPKEPRHLTEEEQLLFQDFSYTA 1498
            ||.|||:.....:|...|   :.....||:.||:.|
Human   376 FDPEFTARTPTDSPGVPP---SANAHHLFRGFSFVA 408

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PknNP_001097237.1 HR1_PKN_1 131..194 CDD:212012
HR1_PKN_2 243..309 CDD:212013
HR1_PKN_3 340..414 CDD:212015
C2 530..611 CDD:472691
STKc_PKN 1174..1499 CDD:270741 135/329 (41%)
RPS6KA2XP_006715612.1 STKc_RSK_N 91..407 CDD:270734 131/322 (41%)
STKc_RSK3_C 439..731 CDD:271080
Blue background indicates that the domain is not in the aligned region.

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