DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkn and PRKCQ

DIOPT Version :9

Sequence 1:	NP_001097237.1	Gene:	Pkn / 35950	FlyBaseID:	FBgn0020621	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	XP_005252553.1	Gene:	PRKCQ / 5588	HGNCID:	9410	Length:	740	Species:	Homo sapiens

Alignment Length:	339	Identity:	157/339 - (46%)
Similarity:	230/339 - (67%)	Gaps:	11/339 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly  1161 KQPPNAGM-LSMDNFRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVESLLSEKR 1224
            |:.|:..: |.:::|.|..:||:|.||||.|::.:..||::|||||||..::..|:||..:.|||
Human   400 KERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKR 464

  Fly  1225 IFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIHT-DVFLEPRAVFYAACVVLGLQ 1288
            :..:  |..||||.:::..|||::::.|||||..|||||.||.: ..|...||.||||.::||||
Human   465 VLSL--AWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQ 527

  Fly  1289 YLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGD-RTGTFCGTPEFLAPEVLTETSYT 1352
            :||...|:||||||||:|||.:|::||||||:|||.| .|| :|.||||||:::|||:|....|.
Human   528 FLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENM-LGDAKTNTFCGTPDYIAPEILLGQKYN 591

  Fly  1353 RAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRRLLRKNPERRL 1417
            .:||||..|||::|||:|:|||.|.||||:|.||..|...|||:|..||..::.:|..:.||:||
Human   592 HSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRL 656

  Fly  1418 GSSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLTPPKEPRH 1482
            |.    ..|:::...||.|.|::|..:::.|||.|.:....|.||||:||.:||.:|: ..:...
Human   657 GV----RGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLS-FADRAL 716

  Fly  1483 LTEEEQLLFQDFSY 1496
            :...:|.:|::||:
Human   717 INSMDQNMFRNFSF 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012
		HR1_PKN_2	243..309	CDD:212013
		HR1_PKN_3	340..414	CDD:212015
		C2	530..611	CDD:301316
		STKc_PKN	1174..1499	CDD:270741	154/325 (47%)
		S_TKc	1174..1433	CDD:214567	131/260 (50%)
PRKCQ	XP_005252553.1	C1_1	194..246	CDD:278556
		C1_1	266..318	CDD:278556
		STKc_nPKC_theta	408..738	CDD:270770	155/331 (47%)
		S_TKc	414..668	CDD:214567	131/260 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0694
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840