DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pkn and PRKCI

DIOPT Version :10

Sequence 1:NP_001097237.1 Gene:Pkn / 35950 FlyBaseID:FBgn0020621 Length:1501 Species:Drosophila melanogaster
Sequence 2:NP_002731.4 Gene:PRKCI / 5584 HGNCID:9404 Length:596 Species:Homo sapiens


Alignment Length:532 Identity:185/532 - (34%)
Similarity:280/532 - (52%) Gaps:72/532 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   997 VPPSPLVEYPEDDDEYLYRGSNENLGTRLHSSHSSSAGDRF--------CVEVIPQLGKLYVGSS 1053
            ||..|.:..|.:|.....||:.........:.|:..| .||        |.:.|..||:      
Human   109 VPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQA-KRFNRRAHCAICTDRIWGLGR------ 166

  Fly  1054 QQQYAQQSSPIIQEPATPTIYGNSAAAGAPQFPQPAQRQEKQPPQQQPIYANQYELNVAKAAAAA 1118
             |.|...:..::.......:.  :...|....||    :...|..|..::::.        |...
Human   167 -QGYKCINCKLLVHKKCHKLV--TIECGRHSLPQ----EPVMPMDQSSMHSDH--------AQTV 216

  Fly  1119 SVYSPSSSTTSNSNQQQQQQRRNVARGLQYRESGGLETGRAGKQPPNAGMLSMDNFRLLSVLGRG 1183
            ..|:|||..:.:...::::       .:..||||...:.           |.:.:|.||.|:|||
Human   217 IPYNPSSHESLDQVGEEKE-------AMNTRESGKASSS-----------LGLQDFDLLRVIGRG 263

  Fly  1184 HFGKVILSQLRSNNQYYAIKALKKGDIIARDEVESLLSEKRIFEVANAMRHPFLVNLYSCFQTEQ 1248
            .:.||:|.:|:..::.||:|.:||..:...::::.:.:||.:||  .|..|||||.|:||||||.
Human   264 SYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFE--QASNHPFLVGLHSCFQTES 326

  Fly  1249 HVCFVMEYAAGGDLMMHIHTDVFL-EPRAVFYAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGY 1312
            .:.||:||..|||||.|:.....| |..|.||:|.:.|.|.||||..||||||||||:|||:||:
Human   327 RLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGH 391

  Fly  1313 VKIADFGLCKEGMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIFEMLVGESPF--- 1374
            :|:.|:|:||||:..||.|.||||||.::|||:|....|..:||||.||||:|||:.|.|||   
Human   392 IKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIV 456

  Fly  1375 -----PGDDEEE-VFDSIVNDEVRYPRFLSLEAIAVMRRLLRKNPERRLGSSERDA-EDVKKQAF 1432
                 |..:.|: :|..|:..::|.||.||::|.:|::..|.|:|:.|||...:.. .|::...|
Human   457 GSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPF 521

  Fly  1433 FRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLTPPKEP--RHLTEEEQLLFQDFS 1495
            ||::.||.:..::|.|||.|.|:....:.|||.:||:|..||||..:.  |.:.:.|   |:.|.
Human   522 FRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSE---FEGFE 583

  Fly  1496 Y------TAEWC 1501
            |      :||.|
Human   584 YINPLLMSAEEC 595

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PknNP_001097237.1 HR1_PKN_1 131..194 CDD:212012
HR1_PKN_2 243..309 CDD:212013
HR1_PKN_3 340..414 CDD:212015
C2 530..611 CDD:472691
STKc_PKN 1174..1499 CDD:270741 150/343 (44%)
PRKCINP_002731.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Regulatory domain 2..253 32/183 (17%)
Required for interaction with RAB2 2..28
PB1_aPKC 26..108 CDD:99725
Interaction with PARD6A 72..91
Pseudosubstrate. /evidence=ECO:0000250 125..134 2/8 (25%)
C1_aPKC 139..193 CDD:410344 11/63 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 220..246 7/32 (22%)
STKc_aPKC_iota 233..596 CDD:270769 158/386 (41%)
Blue background indicates that the domain is not in the aligned region.

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