DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkn and PRKCE

DIOPT Version :9

Sequence 1:	NP_001097237.1	Gene:	Pkn / 35950	FlyBaseID:	FBgn0020621	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	NP_005391.1	Gene:	PRKCE / 5581	HGNCID:	9401	Length:	737	Species:	Homo sapiens

Alignment Length:	414	Identity:	179/414 - (43%)
Similarity:	261/414 - (63%)	Gaps:	33/414 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly  1112 AKAAAAASVYSPS------SSTTSNSNQQQQQQRRNVARGLQYRESGGLETGRAGKQPP------ 1164
            |::...||..|||      |:.||..:|:.::...|:.:.|.:...|  |..||...|.
Human   327 AESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRG--EEHRAASSPDGQLMSP 389

  Fly  1165 ---------NAGMLSMDNFRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVESLL 1220
                     .|..|.:|.|..:.|||:|.||||:|::|:..::.||:|.|||..|:..|:|:..:
Human   390 GENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTM 454

  Fly  1221 SEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHI-HTDVFLEPRAVFYAACVV 1284
            :||||  :|.|.:||:|..||.||||:..:.|||||..|||||..| .:..|.|||:.||||.|.
Human   455 TEKRI--LALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVT 517

  Fly  1285 LGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPEFLAPEVLTET 1349
            ..|.:||::.:|||||||||:|||.||:.|:||||:||||:..|..|.||||||:::|||:|.|.
Human   518 SALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQEL 582

  Fly  1350 SYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRRLLRKNPE 1414
            .|..:||||.||||::||:.|:.||..|:|:::|:||::|:|.||.:||.||:::::..:.|||.
Human   583 EYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPH 647

  Fly  1415 RRLG--SSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLTPP 1477
            :|||  :|:...:.:|:..||:.|.|..|..:|:||||.|.|....||:|||::||.|:..||..
Human   648 KRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLV 712

  Fly  1478 KEP--RHLTEEEQLLFQDFSYTAE 1499
            .|.  :.:.:||   |:.|||..|
Human   713 DEAIVKQINQEE---FKGFSYFGE 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012
		HR1_PKN_2	243..309	CDD:212013
		HR1_PKN_3	340..414	CDD:212015
		C2	530..611	CDD:301316
		STKc_PKN	1174..1499	CDD:270741	158/329 (48%)
		S_TKc	1174..1433	CDD:214567	129/261 (49%)
PRKCE	NP_005391.1	C2_PKC_epsilon	3..135	CDD:175981
		C1_nPKC_epsilon-like_rpt1	161..224	CDD:410385
		Interaction with actin. /evidence=ECO:0000250	223..228
		C1_nPKC_epsilon-like_rpt2	241..295	CDD:410388
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	325..356		10/28 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..398		5/29 (17%)
		STKc_nPKC_epsilon	412..732	CDD:270743	157/324 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149257
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0694
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.770