DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkn and PRKCA

DIOPT Version :9

Sequence 1:	NP_001097237.1	Gene:	Pkn / 35950	FlyBaseID:	FBgn0020621	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	NP_002728.2	Gene:	PRKCA / 5578	HGNCID:	9393	Length:	672	Species:	Homo sapiens

Alignment Length:	368	Identity:	167/368 - (45%)
Similarity:	231/368 - (62%)	Gaps:	25/368 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly  1150 ESGGLE---------TGRAG----------KQPP-NAGMLSMDNFRLLSVLGRGHFGKVILSQLR 1194
            |.|.:|         .|.||          |||. |...:.:.:|..|.|||:|.||||:|:..:
Human   295 EEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRK 359

  Fly  1195 SNNQYYAIKALKKGDIIARDEVESLLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAAG 1259
            ...:.||||.|||..:|..|:||..:.|||:..:.:  :.|||..|:|||||...:.|||||..|
Human   360 GTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLD--KPPFLTQLHSCFQTVDRLYFVMEYVNG 422

  Fly  1260 GDLMMHI-HTDVFLEPRAVFYAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKE 1323
            ||||.|| ....|.||:||||||.:.:||.:||:..||||||||||::||:||::||||||:|||
Human   423 GDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKE 487

  Fly  1324 GMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVN 1388
            .|..|..|.||||||:::|||::....|.::||||..|||::|||.|:.||.|:||:|:|.||:.
Human   488 HMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIME 552

  Fly  1389 DEVRYPRFLSLEAIAVMRRLLRKNPERRLGSSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPT 1453
            ..|.||:.||.||::|.:.|:.|:|.:|||.......||::.||||.|.|:.|..|:::|||.|.
Human   553 HNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPK 617

  Fly  1454 INHLEDVSNFDEEFTSEKAQLTPPKEPRHLTEEEQLLFQDFSY 1496
            :.. :...|||:.||..:..|||| :...:...:|..|:.|||
Human   618 VCG-KGAENFDKFFTRGQPVLTPP-DQLVIANIDQSDFEGFSY 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012
		HR1_PKN_2	243..309	CDD:212013
		HR1_PKN_3	340..414	CDD:212015
		C2	530..611	CDD:301316
		STKc_PKN	1174..1499	CDD:270741	157/324 (48%)
		S_TKc	1174..1433	CDD:214567	132/259 (51%)
PRKCA	NP_002728.2	C1_1	37..89	CDD:278556
		C1_1	102..154	CDD:278556
		C2_PKC_alpha_gamma	159..289	CDD:175992
		STKc_cPKC_alpha	328..668	CDD:270766	158/335 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149249
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.870