Protein Alignment Pkn and PRKACG

DIOPT Version :10

• Sequence 1: NP_001097237.1
• Gene: Pkn / 35950
• FlyBaseID: FBgn0020621
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_002723.2
• Gene: PRKACG / 5568
• HGNCID: 9382
• Length: 351
• Species: Homo sapiens
• Alignment Length: 313
• Identity: 125/313 - (39%)
• Similarity: 184/313 - (58%)
• Gaps: 8/313 - (2%)

  Fly  1164 PNAGMLSMDNFRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVESLLSEKRIFEV 1228
            |.....|.|.|..|..||.|.||:|:|.:.:....:||:|.|.|..::...:||.:|:||||.:
Human    34 PAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQ- 97

  Fly  1229 ANAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHI-HTDVFLEPRAVFYAACVVLGLQYLHE 1292
              |:..||||.|...|:...::..||||..||::...: ....|.||.|.||||.|||.:||||.
Human    98 --AIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHS 160

  Fly  1293 NKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDW 1357
            ..:|:||||.:|||:|.:||:::.|||..|...|   ||.|.|||||:||||::....|.:||||
Human   161 LDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILSKGYNKAVDW 222

  Fly  1358 WGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRRLLRKNPERRLGSSER 1422
            |.|||||:||.||..||..|...::::.||:..||:|..||.:...::|.||:.:..:|.|:...
Human   223 WALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRN 287

  Fly  1423 DAEDVKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLT 1475
            ...|:|...:|.:..|..:..:||:.||:|......|.|||| ::..|:.:::
Human   288 GVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFD-DYEEEELRIS 339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012
		HR1_PKN_2	243..309	CDD:212013
		HR1_PKN_3	340..414	CDD:212015
		C2	530..611	CDD:472691
		STKc_PKN	1174..1499	CDD:270741	122/303 (40%)
PRKACG	NP_002723.2	STKc_PKA	42..331	CDD:271111	122/295 (41%)