Protein Alignment Pkn and PRKACB

DIOPT Version :10

• Sequence 1: NP_001097237.1
• Gene: Pkn / 35950
• FlyBaseID: FBgn0020621
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_891993.1
• Gene: PRKACB / 5567
• HGNCID: 9381
• Length: 398
• Species: Homo sapiens
• Alignment Length: 302
• Identity: 123/302 - (40%)
• Similarity: 180/302 - (59%)
• Gaps: 10/302 - (3%)

  Fly  1165 NAGMLSMDNFRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVESLLSEKRIFEVA 1229
            |||   :::|.....||.|.||:|:|.:.::..||||:|.|.|..::...::|..|:||||.:..
Human    85 NAG---LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAV 146

  Fly  1230 NAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHI-HTDVFLEPRAVFYAACVVLGLQYLHEN 1293
            |   .||||.|...|:...::..||||..||::..|: ....|.||.|.||||.:||..:|||..
Human   147 N---FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 208

  Fly  1294 KIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWW 1358
            .:||||||.:|||:|.:||:::.|||..|...|   ||.|.|||||:||||::....|.:|||||
Human   209 DLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILSKGYNKAVDWW 270

  Fly  1359 GLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRRLLRKNPERRLGSSERD 1423
            .|||||:||..|..||..|...::::.||:.:||:|...|.:...::|.||:.:..:|.|:.:..
Human   271 ALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNG 335

  Fly  1424 AEDVKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDE 1465
            ..|:|...:|.:..|..:..|||:.||:|......|.||||:
Human   336 VSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDD 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012
		HR1_PKN_2	243..309	CDD:212013
		HR1_PKN_3	340..414	CDD:212015
		C2	530..611	CDD:472691
		STKc_PKN	1174..1499	CDD:270741	120/293 (41%)
PRKACB	NP_891993.1	STKc_PKA	89..378	CDD:271111	120/295 (41%)