DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkn and Pkc53E

DIOPT Version :9

Sequence 1:	NP_001097237.1	Gene:	Pkn / 35950	FlyBaseID:	FBgn0020621	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster

Alignment Length:	331	Identity:	166/331 - (50%)
Similarity:	220/331 - (66%)	Gaps:	6/331 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly  1168 MLSMDNFRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVESLLSEKRIFEVANAM 1232
            |:...:|..:.|||:|.||||:|::.:.:.:.||||.|||..||..|:||..:.|||:  :|...
  Fly   344 MIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRV--LALGE 406

  Fly  1233 RHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIHT-DVFLEPRAVFYAACVVLGLQYLHENKII 1296
            :.||||.|:|||||...:.|||||..|||||..|.. ..|.||.||||||.:..||.:||...|:
  Fly   407 KPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGIL 471

  Fly  1297 YRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDR-TGTFCGTPEFLAPEVLTETSYTRAVDWWGL 1360
            ||||||||:|||.:|:|||||||:|||.: .||: |.||||||:::|||::....|.::||||..
  Fly   472 YRDLKLDNVLLDADGHVKIADFGMCKENI-VGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAY 535

  Fly  1361 GVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRRLLRKNPERRLGSSERDAE 1425
            |||::|||||:.||.|:||||:|.:|.:..|.||:.||.||....:..|.|.|.:|||......|
  Fly   536 GVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEE 600

  Fly  1426 DVKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLTPPKEPRHLTEEEQLL 1490
            ||:...|||.|.|:.:..|:|:|||.|.|.|.:||||||::|||||..|| |.:...:...:|..
  Fly   601 DVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLT-PTDKVFMMNLDQSE 664

  Fly  1491 FQDFSY 1496
            |..|||
  Fly   665 FVGFSY 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012
		HR1_PKN_2	243..309	CDD:212013
		HR1_PKN_3	340..414	CDD:212015
		C2	530..611	CDD:301316
		STKc_PKN	1174..1499	CDD:270741	165/325 (51%)
		S_TKc	1174..1433	CDD:214567	133/260 (51%)
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992
		STKc_cPKC	353..672	CDD:270739	164/322 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452325
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D27201at7147
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.980