Protein Alignment Pkn and Akt1

DIOPT Version :9

• Sequence 1: NP_001097237.1
• Gene: Pkn / 35950
• FlyBaseID: FBgn0020621
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_732113.3
• Gene: Akt1 / 41957
• FlyBaseID: FBgn0010379
• Length: 611
• Species: Drosophila melanogaster
• Alignment Length: 616
• Identity: 204/616 - (33%)
• Similarity: 304/616 - (49%)
• Gaps: 65/616 - (10%)

  Fly   908 AEQTSPTLANQTPTFPPLASNQIMPSLNARPCQSQSPNHN-------EFQLQPQ-PPHPAQKPTN 964
            |...:|..|::.|..|....:.|   :|....||..||.:       :|..|.. |...:..||:
  Fly    16 ASAPAPGSASRIPESPTTTGSNI---INIIYSQSTHPNSSPTSGSAEKFSWQQSWPSRTSAAPTH 77

  Fly   965 PEPPSAVEQQLHRPVLILPPVVLLGG--REEDRSVPPSPLVEYPEDDDEYLYR-----GSNENLG 1022
            .....::.....    :..|.|..|.  .|:.:.|....|::..|....:..|     .....:|
  Fly    78 DSGTMSINTTFD----LSSPSVTSGHALTEQTQVVKEGWLMKRGEHIKNWRQRYFVLHSDGRLMG 138

  Fly  1023 TRLHSSHSSSAGDRFCVEVIPQLGKLYVGSSQQQYAQQSSP---IIQEPATPTIYGNSAAAGAPQ 1084
            .|...:.|:|....|.      |....|...|.....:..|   ||:.....|:...:.|.
  Fly   139 YRSKPADSASTPSDFL------LNNFTVRGCQIMTVDRPKPFTFIIRGLQWTTVIERTFAV---- 193

  Fly  1085 FPQPAQRQEKQPPQQQPIYA----NQYELNVAKAAAAASVYSPSSSTTSNSNQQQQQQRRNVARG 1145
                    |.:..:||...|    :...::|.:.|...|..:..:.....:..:.:...:...:|
  Fly   194 --------ESELERQQWTEAIRNVSSRLIDVGEVAMTPSEQTDMTDVDMATIAEDELSEQFSVQG 250

  Fly  1146 LQYRESGGLETGRAGKQPPNAGMLSMDNFRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDI 1210
            .....||             ...::::||..|.|||:|.||||||.:.::..:.||||.|||..|
  Fly   251 TTCNSSG-------------VKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVI 302

  Fly  1211 IARDEVESLLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHI-HTDVFLEP 1274
            |.:|||...|:|.|:.:..|   ||||::|...|||...:||||:|..||:|..|: |..:|.|.
  Fly   303 IQKDEVAHTLTESRVLKSTN---HPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTED 364

  Fly  1275 RAVFYAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPE 1339
            |..||.|.::..|.|||...||||||||:|||||.:|::|:||||||||.:.:|..|.|||||||
  Fly   365 RTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPE 429

  Fly  1340 FLAPEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAV 1404
            :||||||.:..|.:||||||.||:::||:.|..||...|.:.:|..|:.:||::||.::.||..:
  Fly   430 YLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNL 494

  Fly  1405 MRRLLRKNPERRLGSSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTS 1469
            :..||.|:|::|||..:.|.::::...||.||.|.||:|:|:.|||.|.:....|...||:|||.
  Fly   495 LAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTG 559

  Fly  1470 EKAQLTPPKEPRHL-TEEEQLLFQDFSYTAE 1499
            |..:||||.....| :..|:.||..|||..:
  Fly   560 ESVELTPPDPTGPLGSIAEEPLFPQFSYQGD 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012
		HR1_PKN_2	243..309	CDD:212013
		HR1_PKN_3	340..414	CDD:212015
		C2	530..611	CDD:301316
		STKc_PKN	1174..1499	CDD:270741	156/326 (48%)
		S_TKc	1174..1433	CDD:214567	125/259 (48%)
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947	21/126 (17%)
		PH	107..211	CDD:278594	21/121 (17%)
		S_TKc	266..523	CDD:214567	125/259 (48%)
		STKc_PKB	270..590	CDD:270723	154/322 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D27201at7147
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.020