DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkn and trc

DIOPT Version :9

Sequence 1:	NP_001097237.1	Gene:	Pkn / 35950	FlyBaseID:	FBgn0020621	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster

Alignment Length:	418	Identity:	123/418 - (29%)
Similarity:	208/418 - (49%)	Gaps:	73/418 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1129 SNSNQQQQQQRRNVARGLQYRESGGLETGRAGKQPPNAGMLSMDNFRLLSVLGRGHFGKVILSQL 1193
            |.|..|:|::|...|:    :|:..|...|.        .|.:::|..|.|:|||.||:|.|.|.
  Fly    60 SLSEAQRQEKRLQHAQ----KETEYLRLKRL--------RLGVEDFEALKVIGRGAFGEVRLVQK 112

  Fly  1194 RSNNQYYAIKALKKGDIIARDEVESLLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAA 1258
            :.....||:|.|:|.|::.:::|..:.:|:.:...|:   |.::|.:|..||...::..:||:..
  Fly   113 KDTGHVYAMKVLRKADMLEKEQVAHVRAERDVLVEAD---HQWVVKMYYSFQDPVNLYLIMEFLP 174

  Fly  1259 GGDLM-MHIHTDVFLEPRAVFYAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCK 1322
            |||:| :.:..|...|....||.:...|.:..:|:...|:||:|.||||||..|::|::|||||
  Fly   175 GGDMMTLLMKKDTLSEEGTQFYISETALAIDSIHKLGFIHRDIKPDNLLLDARGHLKLSDFGLC- 238

  Fly  1323 EGMGFGDRT---------------GTFC-----------------------------GTPEFLAP 1343
            .|:....||               || |                             |||:::||
  Fly   239 TGLKKSHRTDFYRDLSQAKPSDFIGT-CASLSCSPMDSKRRAESWKRNRRALAYSTVGTPDYIAP 302

  Fly  1344 EVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVN--DEVRYPRF--LSLEAIAV 1404
            ||..:|.|..|.|||.|||:::|||:|..||..|:.::.:..::|  :.:.:|..  :|.||...
  Fly   303 EVFLQTGYGPACDWWSLGVIMYEMLMGYPPFCSDNPQDTYRKVMNWRETLIFPPEIPISEEAKET 367

  Fly  1405 MRRLLRKNPERRLGSSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPT-INHLEDVSNFDEEFT 1468
            :.....: .:|||| |:|..||:|...|||.:.|:.:   :.:|..:|. :..::|.|||| ||.
  Fly   368 IINFCCE-ADRRLG-SQRGLEDLKSVPFFRGVDWEHI---RERPAAIPVEVRSIDDTSNFD-EFP 426

  Fly  1469 SEKAQLTPPKEPRHLTEEEQLLFQDFSY 1496
            ....::.....|:.....:..:|.:::|
  Fly   427 DVSLEIPSAPIPQGGEIAKDWVFINYTY 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012
		HR1_PKN_2	243..309	CDD:212013
		HR1_PKN_3	340..414	CDD:212015
		C2	530..611	CDD:301316
		STKc_PKN	1174..1499	CDD:270741	113/373 (30%)
		S_TKc	1174..1433	CDD:214567	97/307 (32%)
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	8/28 (29%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	113/375 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010