DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkn and prkcbb

DIOPT Version :9

Sequence 1:	NP_001097237.1	Gene:	Pkn / 35950	FlyBaseID:	FBgn0020621	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	NP_957272.1	Gene:	prkcbb / 393953	ZFINID:	ZDB-GENE-040426-1178	Length:	670	Species:	Danio rerio

Alignment Length:	379	Identity:	160/379 - (42%)
Similarity:	231/379 - (60%)	Gaps:	15/379 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly  1123 PSSSTTSNSNQQQQQQRRNVARGLQYRESGGLETGRAGKQPPNAG--MLSMDNFRLLSVLGRGHF 1185
            |......|...:|:.:|..:...    ::.|..:....|...|..  .:.:.:|..|.|||:|.|
Zfish   290 PPEGEEGNEELRQKFERAKIGPS----KTDGSSSNAISKFDSNGNRDRMKLSDFNFLMVLGKGSF 350

  Fly  1186 GKVILSQLRSNNQYYAIKALKKGDIIARDEVESLLSEKRIFEVANAMRHPFLVNLYSCFQTEQHV 1250
            |||:|::.:..::.:|||.|||..:|..|:||..:.|||:..::.  :.|||..|:|||||...:
Zfish   351 GKVMLAERKGADELFAIKILKKDVVIQDDDVECTMVEKRVLALSG--KPPFLTQLHSCFQTMDRL 413

  Fly  1251 CFVMEYAAGGDLMMHI-HTDVFLEPRAVFYAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVK 1314
            .|||||..|||||.|| ....|.||.||||||.:.:||.:||...:|||||||||::||.||::|
Zfish   414 YFVMEYINGGDLMYHIQQVGKFKEPHAVFYAAEIAIGLFFLHSKGVIYRDLKLDNVMLDAEGHIK 478

  Fly  1315 IADFGLCKEGMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDE 1379
            |||||:|||.|..|..|.||||||:::|||::....|.::||||..|||::|||.|:.||.|:||
Zfish   479 IADFGMCKENMLDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQPPFDGEDE 543

  Fly  1380 EEVFDSIVNDEVRYPRFLSLEAIAVMRRLLRKNPERRLGSSERDAEDVKKQAFFRSIVWDDLLLR 1444
            :|:|.||:...|.||:.:|.||:|:.:.|:.|:|.:|||.......|:::..|||.:.|:.|..|
Zfish   544 DELFQSIMEHHVSYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIREHGFFRYMDWEKLEHR 608

  Fly  1445 KVKPPFVPTINHLEDVSNFDEEFTSEKAQLTPPKEP--RHLTEEEQLLFQDFSY 1496
            :|:|||.|.... .|..|||..||.....||||.:.  .:|.::|   |:.||:
Zfish   609 EVQPPFKPKACG-RDAENFDRFFTRHPPVLTPPDQEVIMNLDQDE---FEGFSF 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012
		HR1_PKN_2	243..309	CDD:212013
		HR1_PKN_3	340..414	CDD:212015
		C2	530..611	CDD:301316
		STKc_PKN	1174..1499	CDD:270741	153/326 (47%)
		S_TKc	1174..1433	CDD:214567	127/259 (49%)
prkcbb	NP_957272.1	C1_1	36..88	CDD:278556
		C1_1	101..151	CDD:278556
		C2_PKC_alpha_gamma	158..288	CDD:175992
		STKc_cPKC_beta	338..660	CDD:270767	153/327 (47%)
		S_TKc	339..597	CDD:214567	127/259 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583337
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.870