Protein Alignment Pkn and S6kII

DIOPT Version :10

• Sequence 1: NP_001097237.1
• Gene: Pkn / 35950
• FlyBaseID: FBgn0020621
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Alignment Length: 611
• Identity: 175/611 - (28%)
• Similarity: 270/611 - (44%)
• Gaps: 130/611 - (21%)

  Fly   924 PLASNQIMPSLNARPCQSQSPNHNEFQLQPQPPHPAQKPTNPEPPSAVEQQLHRPVLILPPVVLL 988
            |||.:|                 .:.:.|||.....|..::....:..|||.....        |
  Fly     2 PLADSQ-----------------KDLRQQPQQQQQQQHVSSTSSSNNAEQQCSSSG--------L 41

  Fly   989 GGREEDR---------SVPPSPLVEYPEDDDEYLYRGSNENLGTRLHSSHSSSAGDRFCVEVIPQ 1044
            |.:...|         |:..:|:...|.:|||  ..|.|..:.:.:.:..||....        |
  Fly    42 GLQLRQRMQITSSGCSSLAVTPMEHTPTEDDE--SGGGNSGVTSSVTTVTSSQRRQ--------Q 96

  Fly  1045 LGKLYVGSSQQQYAQQSSPIIQEPATPTIYGNSAAAGAPQFPQPAQRQEKQPPQQQPIYANQYEL 1109
            |.::     |||.|.|:: :.|...:||...:||.      .:|..|....||:...:
  Fly    97 LQQV-----QQQSALQAA-LEQHHISPTADLDSAR------KRPTHRTLCPPPELMEL------- 142

  Fly  1110 NVAKAAAAASVYSPSSSTTSNSNQQQQQQRRNVARGLQYRESGGLETGRAGKQPPN----AGMLS 1170
                               |:|..|         .|:   |:||...|..|:..|:    ..:..
  Fly   143 -------------------SDSESQ---------GGV---ETGGRREGATGRSAPDLEDTEPLYE 176

  Fly  1171 MDN-------------------FRLLSVLGRGHFGKVILSQL---RSNNQYYAIKALKKGDIIAR 1213
            .:|                   |.||.|||.|.||||.|.:.   :.....||:|.|||..:..:
  Fly   177 TENEFELKEVIKEGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVK 241

  Fly  1214 DEVESLLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIHTDV-FLEPRAV 1277
            |.|.|....|.:.:|.    |.|:|.|:..|||...:..::::..||||...:..:| |.|....
  Fly   242 DRVRSTNERKILADVG----HAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVK 302

  Fly  1278 FYAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPEFLA 1342
            ||.|.:.|.:.:||...|||||||.:|:|||..|::.:.||||.|:.:. |.:|.:||||.|::|
  Fly   303 FYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLD-GSKTYSFCGTVEYMA 366

  Fly  1343 PEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRR 1407
            ||::....:..|.|||..|||::|||.|..||.|...:|..:.|:..::..|..||.||.:::|.
  Fly   367 PEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRA 431

  Fly  1408 LLRKNPERRLGSSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKA 1472
            |.::||:.|||:..:...|:|...||.:|.|..|..::|:|||:|.::. :|...||.|:|| |:
  Fly   432 LFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAVSR-DDAFYFDVEYTS-KS 494

  Fly  1473 QLTPPKEPRHLTEEEQLLFQDFSYTA 1498
            ....|..|...:..|  :|:.||:.|
  Fly   495 PRDSPGGPISASAHE--IFRGFSFVA 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012
		HR1_PKN_2	243..309	CDD:212013
		HR1_PKN_3	340..414	CDD:212015
		C2	530..611	CDD:472691
		STKc_PKN	1174..1499	CDD:270741	124/329 (38%)
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	120/322 (37%)
		STKc_RSK_C	567..883	CDD:270993