Protein Alignment Pkn and Pkcdelta

DIOPT Version :10

• Sequence 1: NP_001097237.1
• Gene: Pkn / 35950
• FlyBaseID: FBgn0020621
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_572797.3
• Gene: Pkcdelta / 32191
• FlyBaseID: FBgn0287828
• Length: 1894
• Species: Drosophila melanogaster
• Alignment Length: 1911
• Identity: 428/1911 - (22%)
• Similarity: 666/1911 - (34%)
• Gaps: 634/1911 - (33%)

  Fly    12 INPSSQRDREDTTSVSASEGFIARRKCHSLPRRSNRHSTARRSNSGLWNRLVTNVF--------- 67
            :.||.:....:::..||.             .|.||.||.||      ||.|..:.
  Fly   186 VKPSPKETPCESSDASAE-------------TRPNRRSTIRR------NRPVVRLSTIRRRSKDR 231

  Fly    68 --------------------GPEDSYDFDNEGDSGGAVFYTDSVNGSNYEISAEGEYIK------ 106
                                ..|.|..:..:.....|.|...|...|..|:..|..|||
  Fly   232 SAESPKKEQVQEHQFRDLPPATEPSLSWRQKLAEELAAFPVTSNKKSPGELLRERFYIKDEKEEL 296

  Fly   107 ----HPVLYELSHKYGFTENLPESCMSIRLEEIKEAIRREI--RKELKIKEGAEKLREVAKDRRS 165
                ...:.||..        |:|.......|::.:.::|:  .||.:..:..::|.|:.:..|.
  Fly   297 TNFNRAQIQELVQ--------PQSAHKTLTPEVEISAKKEVDDEKEDESDKQEQELEEMQETIRR 353

  Fly   166 LS--------DVAVLVKKSK-------SKLAELKSELQELESQIL-----------------LTS 198
            ||        |:...:...|       .:|....|.:||.|.:||                 ..|
  Fly   354 LSLVQCPTFHDICEDISSDKIDDDLNAGELRRRASIIQEQEQEILNKLQKSNSGSFQLIHLERRS 418

  Fly   199 ANTAVNSNGQE-----------------SITACIDPNG-------------------GFLVSGAV 227
            ::.:..:|.::                 .|||.::...                   ..|:....
  Fly   419 SHDSTTTNDEDLKERSKRRSKKSKKMRHKITAIVEVENAPQAQPVEHMPSVLELNEESLLIQPLT 483

  Fly   228 GGLGGGNTALEGGAPA-TANDKVLASLEKQLQIEM-----KVKTGAENMIQSLGIGCDKKLLAEA 286
            .|.|..:|......|. |.|   :.::|:..||..     |.||..::.        |...|.|.
  Fly   484 SGSGSSSTPTPSPKPKFTVN---VETVEEHHQIHKIFKLPKKKTVPKDQ--------DDSSLPEG 537

  Fly   287 HQMLADSKAKIEFLRLRIIKVKQNREQADRLKASRQMIDEHGQTIGGNNSSQPQSLETTLEERIE 351
            ....|....|..  .|:.:..:|:..:|.........|.:..|.  .....||:..:|
  Fly   538 FMKAAPKTTKTS--PLKKVNKQQHVNEAQIFTFDEAAIQQQQQV--QQQQQQPELPKT------- 591

  Fly   352 ELRHRLRIEAAVVDGAKNVIRTLQTANRAPDKKALQEAHG------------RLSESSRK--LDL 402
                     .|.|:|         .|...|.:||:|::..            .|..::||  .::
  Fly   592 ---------EAKVEG---------VATPKPIRKAIQKSESGEDFWSQIGSRETLYMTNRKKVFNM 638

  Fly   403 LRYSLDLRRQELPADSPA-AQQLKTELQ-----------IVQLSTSPA----------------P 439
            .:...:...:|.|..||| .::.||:|:           :::|.|:|:                |
  Fly   639 RQEQQEQLLEEEPPKSPAMPKETKTDLKTPTTPKLKSEILIELKTTPSIVSTSGKSETQKVPSTP 703

  Fly   440 VTYTSLQSGQAGILGGKPYQSVSSLGRC-ASVTGKL--EVRLLGCQDLLEDVPGRSRRD--KDNN 499
            :|.|.:::.|   :..|..:|:.:..:. |||..|.  ..:|....|..:..|..:::|  |...
  Fly   704 LTPTVVKTNQ---VEAKKVESMDTSSKAPASVISKAAESPKLKSATDNNKAKPTMAKKDLPKLKT 765

  Fly   500 SSPGDLRSFVKGVT---SRSSSKSYSVKDETSIEIMAVIKLDNITVGQTSWKQCSQQAWDQRFSI 561
            :....|....|..|   :..|.|:...|:|||                    |.::.|...:...
  Fly   766 AEETKLTITTKATTATPTMDSPKTPQAKEETS--------------------QKTESATTSQIKS 810

  Fly   562 DLDRSRELEIGVYWRDWRSLCAVKVLRLEEFIDDVRHGMALQLEPQGLLFAEVKFLNPMISQ--- 623
            |..                                   :|||::||    .::|...|...|
  Fly   811 DTP-----------------------------------IALQIKPQ----EQMKVAAPTTPQAKV 836

  Fly   624 --KPKLRRQRMIFNRQQAKNISRAKQMNINVATWGRLLKRNAPNHVHMGSAGSGSSLTGSSPMVV 686
              .||....|.|.    |....:||   :...|      :::|..         ..:|.::|...
  Fly   837 ETPPKDSPTRKIV----APTTPQAK---VETPT------KDSPTR---------KIVTPTTPQAK 879

  Fly   687 GGSRDSESPISR--TPSS-DALVEPEPYTPGEQAQNLEFDPDAGINEHVETPGEYPDP------- 741
            ..:...:||..:  ||:: .|.||    ||.:.:...:..........||||.: ..|
  Fly   880 VETPTKDSPTRKIVTPTTPQAKVE----TPTKDSPTRKIVTPTTPQAKVETPTK-DSPTRKIATP 939

  Fly   742 ----AASGLSGMRPLSMHMQGISVLPPESPPV--------ATGAAGRPNTLSLQMPGASKGQVIQ 794
                |.:..|...||:        .|.::|.|        :|.||.:.....:.|...:...|.:
  Fly   940 TTPQAKAAASTTSPLT--------TPQKTPQVKAATDESKSTPAAPKTTMAKISMTTMAGTTVAE 996

  Fly   795 GGRTAAP--------TTAPPPPPVLKATSTTPILDQELQDALHEFDFLSDLDSRPTTLRRLLK-- 849
            .|:|.:|        ..|.|     .||.|||                    :.|||.....|
  Fly   997 AGKTISPKGLKQSGNAVAMP-----TATPTTP--------------------NTPTTATGKSKLN 1036

  Fly   850 ----------------EQKMALDAGALENLLLQQQQTEQQALQQRQRQEQLRLQQFQEAQRQAIL 898
                            ||:.| .|.|:|..:.:....|||..||:|:|:|.:.||.|.....|.|
  Fly  1037 ETAGPKINSGQPAKSPEQQQA-TAAAVETKINKTTDKEQQQQQQQQQQQQAQQQQQQLIDTAATL 1100

  Fly   899 ----DLCVKQREPAEQT---------------------------------------SPTLANQTP 920
                :...|..|.||.|                                       :|..|..|.
  Fly  1101 VPQTETKTKLTEAAEPTGKSKVQSPNTTKPKSAGKTNVGKKKAATPAAAAAAAAAAAPAAATATE 1165

  Fly   921 TFPPLASNQIMP-------SLNARPCQSQSPN----------HNEFQLQPQPPHPAQKPTNPEPP 968
            ....|:.:.:.|       :|........|||          |.|.|.|.|     |:.||...|
  Fly  1166 AVTALSESNVTPINADQFITLAPTKAAKTSPNKQQALQLQQQHEEQQRQQQ-----QQATNASSP 1225

  Fly   969 SAVEQQLHRPVLILPPVVLLG-------------------------------------------- 989
            :|.......|..|...|..:.
  Fly  1226 AATGDATTTPTTITIGVAAVNVAAVAVVASAAAAAATDAAADATTSLSSNNSCGEGVGNNLSKFA 1290

  Fly   990 ------------GREEDRSVPPSPLVEYPEDDDEYLYRGSNENLGTRLHSSHSSSAGDRFCVEVI 1042
                        ..|.|..:|.|......:|||:....||:.:       .:||..|   |..:.
  Fly  1291 TVSNLAQCLRDVDAELDDYIPSSAENSQEDDDDDDDGSGSSSD-------DYSSVDG---CANLS 1345

  Fly  1043 PQL---------------------------GKLYVGSSQQQYAQQSSPIIQEPATP--------T 1072
            ..:                           .|:.:.::.:.|.::.:|.....|||        .
  Fly  1346 ASMKKKLRKEKKKQKAKAAAAAEAKRFDPHKKIKIDTTNKCYVKEEAPRYPLVATPRPLWKREKI 1410

  Fly  1073 IY---------GNSAAAGAPQFPQPAQRQEKQPPQQQPIYANQYELN----VAKAAA--AASVYS 1122
            :|         |:...:|.............:........|:..:|:    |.||.:  |.:|..
  Fly  1411 VYSDENTDDESGSEEGSGGSLDEDSDDESGGEECSSTSSSASSEDLDAVAMVTKAGSSNATTVLD 1475

  Fly  1123 PSSSTTSNSNQ-------------QQQQQRRNVARGLQYRESGGLETGRAGKQP----------- 1163
            .|:|:.||:..             .......::.|........|.|.|.|...|
  Fly  1476 SSNSSGSNAGTLSVPSAGSGSGGGASTSSSPSIIRMSTCSNDSGFEGGTAPSSPKKMLETSYTYS 1540

  Fly  1164 ---------------PNAGMLSMDNFRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIAR 1213
                           |.....|:|:|..|:|||:|.||||:|::||....|||||.|||..::..
  Fly  1541 QFQKSGRFTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLED 1605

  Fly  1214 DEVESLLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHI-HTDVFLEPRAV 1277
            |:|:|.|.|:::  :|...:||:|.:|:..||||.|:.|||||..|||||.|| .:..|.|.||.
  Fly  1606 DDVDSTLIERKV--LALGTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERAR 1668

  Fly  1278 FYAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPEFLA 1342
            ||.|.::.||::||:..||||||||||:|||.||:|:|||||:||..:.......:|||||:::|
  Fly  1669 FYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMA 1733

  Fly  1343 PEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRR 1407
            ||::....|.:.||||..|||::|||:|:|||.|.||:|:|.||.|:...:|.::|.||..:::.
  Fly  1734 PEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKG 1798

  Fly  1408 LLRKNPERRLGSSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKA 1472
            ||.|:..:|:||....|.|:....|||.|.|..|..|:::|||.|.:.|..|...||..||.|:.
  Fly  1799 LLEKDYTKRIGSQYSPAGDIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERV 1863

  Fly  1473 QLTP-PKEPRHLTEEEQLLFQDFSYT 1497
            :||| .||  .|...:|..|..|:||
  Fly  1864 RLTPIDKE--ILASMDQKQFHGFTYT 1887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012	16/79 (20%)
		HR1_PKN_2	243..309	CDD:212013	14/71 (20%)
		HR1_PKN_3	340..414	CDD:212015	12/87 (14%)
		C2	530..611	CDD:472691	8/80 (10%)
		STKc_PKN	1174..1499	CDD:270741	154/326 (47%)
Pkcdelta	NP_572797.3	Herpes_BLLF1	<802..1131	CDD:282904	85/428 (20%)
		STKc_nPKC_theta_like	1570..1889	CDD:270744	152/322 (47%)