Protein Alignment Pkn and Pkn1

DIOPT Version :10

• Sequence 1: NP_001097237.1
• Gene: Pkn / 35950
• FlyBaseID: FBgn0020621
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_001186522.1
• Gene: Pkn1 / 320795
• MGIID: 108022
• Length: 951
• Species: Mus musculus
• Alignment Length: 1412
• Identity: 520/1412 - (36%)
• Similarity: 670/1412 - (47%)
• Gaps: 485/1412 - (34%)

  Fly   101 EGEYIKHPVLYELSHKYGFT-ENLPESCMSIRLEEIKEAIRREIRKELKIKEGAEKLREVAKD-R 163
            :.|....|..:.|..:.|.. .:|....:..:||..:|.::||||||||:|||||.||....| .
Mouse     8 DSELESEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLKREIRKELKLKEGAENLRRATTDLG 72

  Fly   164 RSLSDVAVLVKKSKSKLAELKSELQELESQILLTSANTAVNSNGQESITACIDPNGGFLVSGAVG 228
            |||:.|.:|::.|..:|..|..:||||.:.::|.                  ||..|
Mouse    73 RSLAPVELLLRGSARRLDLLHQQLQELHAHVVLP------------------DPAAG-------- 111

  Fly   229 GLGGGNTALEGGAP--ATANDKVLASLEKQLQIEMKVKTGAENMIQ--SLGIGCDKKLLAEAHQM 289
              .....:|..|:|  ::.|...:|.|||||.||:|||.|||||||  |.|...|:|||..|.||
Mouse   112 --SDATQSLAEGSPICSSTNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSSKDRKLLLTAQQM 174

  Fly   290 LADSKAKIEFLRLRIIKVKQNREQADRLKASRQMIDEHGQTIGGNNSSQPQSLETTLEERIEELR 354
            |.|||.||:.:|:::.:..| ..||..|::.....:..|....|           .:|.||||||
Mouse   175 LQDSKTKIDIIRMQLRRALQ-ALQAGELESQAAPDEAQGDPELG-----------AVELRIEELR 227

  Fly   355 HRLRIEAAVVDGAKNVIRTLQTANRAPDKKALQEAHGRLSESSRKLDLLRYSLDLRRQELPADSP 419
            |..|:|.||.:|||||:|.|..| :|||:||:.||..:|:||::||.|||.||:.|..|||||.|
Mouse   228 HHFRVEHAVAEGAKNVLRLLSGA-KAPDRKAVSEAQEKLTESNQKLGLLRESLERRLGELPADHP 291

  Fly   420 AAQQLKTELQIVQLSTSPAPVTYTSLQSGQAGILGGKPYQSVSSLGRCASVTGKLEVRLLGCQDL 484
            ..:.|:.||            |..|..:..|.:.|..|....|:|.:.|.:||.||||::||::|
Mouse   292 KGRLLREEL------------TAASSSAFSAILPGPFPATHYSTLSKPAPLTGTLEVRVVGCKNL 344

  Fly   485 LEDVPGRSRRDKDNNSSPGDLRSFV----KGVTSRSSS----KSYSVKDETSIEIMAVIKLDNIT 541
            .|.:|.........:.:|.....|:    :|:.|||.|    .|...:.|.:.|:..|:||||..
Mouse   345 PETIPWSPPPSVGASGTPESRTPFLSRPARGLYSRSGSLSGRSSLRGEAENATEVSTVLKLDNTV 409

  Fly   542 VGQTSWKQCSQQAWDQRFSIDLDRSRELEIGVYWRDWRSLCAVKVLRLEEFIDDVRHGMALQLEP 606
            ||||:||.|...||||.|:::|:|:||||:.|:|||.|.|||:|.|:||:|:|:.||.:.|.:||
Mouse   410 VGQTAWKPCGPNAWDQSFTLELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEP 474

  Fly   607 QGLLFAEVKFLNPMISQKPKLRRQRMIFNRQQAKNISRAKQMNINVATWGRLLKRNAPNHVHMGS 671
            ||.|.|||.|.||:|.:.|:|:||:.||::||.|...||:||||:||||.|||:|..|:.|..|:
Mouse   475 QGCLVAEVTFRNPIIERIPRLQRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPSAVATGT 539

  Fly   672 AGSGSSLTGSSPMVVGGSRDSESPISRTPSSDALVEPEPYTPGEQAQNLEFDPDAGINEHVETPG 736
                                                              |.|:|.
Mouse   540 --------------------------------------------------FSPNAS--------- 545

  Fly   737 EYPDPAASGLSGMRPLSMHMQGISVLPPESPPVATGAAGRPNTLSLQMPGASKGQVIQGGRTAAP 801
                                                            |||
Mouse   546 ------------------------------------------------PGA-------------- 548

  Fly   802 TTAPPPPPVLKATSTTPILDQELQDALHEFDFLSDLDSRPTTLRRLLKEQKMALDAGALENLLLQ 866
                                    :..|..|               :..:|:.|.|.:
Mouse   549 ------------------------EIRHTGD---------------ISMEKLNLGADS------- 567

  Fly   867 QQQTEQQALQQRQRQEQLRLQQFQEAQRQAILDLCVKQREPAEQTSPTLANQTPTFPPLASNQIM 931
                                                   :.:.|.||
Mouse   568 ---------------------------------------DSSSQKSP------------------ 575

  Fly   932 PSLNARPCQSQSPNHNEFQLQPQPPHPAQKPTNPEPPSAVEQQLHRPVLILPPVVLLGGREEDRS 996
            |.|.:..|...||.|             :..|:||.||..::
Mouse   576 PGLPSTSCSLSSPTH-------------ESTTSPELPSETQE----------------------- 604

  Fly   997 VPPSPLVEYPEDDDEYLYRGSNENLGTRLHSSHSSSAGDRFCVEVIPQLGKLYVGSSQQQYAQQS 1061
                                               :.|...|
Mouse   605 -----------------------------------TPGPGLC----------------------- 611

  Fly  1062 SPIIQEPATPTIYGNSAAAGAPQFPQPAQRQEKQPPQQQPIYANQYELNVAKAAAAASVYSPSSS 1126
            ||:.:.|
Mouse   612 SPLRKSP---------------------------------------------------------- 618

  Fly  1127 TTSNSNQQQQQQRRNVARGLQYRESGGLETGRAGKQPPNAGMLSMDNFRLLSVLGRGHFGKVILS 1191
                                                      |::::|:.|:||||||||||:||
Mouse   619 ------------------------------------------LTLEDFKFLAVLGRGHFGKVLLS 641

  Fly  1192 QLRSNNQYYAIKALKKGDIIARDEVESLLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEY 1256
            :.||:.:.:||||||||||:||||||||:.||||........|||||||:.||||.:||||||||
Mouse   642 EFRSSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTRAGHPFLVNLFGCFQTPEHVCFVMEY 706

  Fly  1257 AAGGDLMMHIHTDVFLEPRAVFYAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLC 1321
            :||||||:|||:|||.|||||||:||||||||:|||:||:|||||||||||||||||||||||||
Mouse   707 SAGGDLMLHIHSDVFSEPRAVFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLC 771

  Fly  1322 KEGMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSI 1386
            |||||:||||.|||||||||||||||:|||||||||||||||::|||||||||||||||||||||
Mouse   772 KEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSI 836

  Fly  1387 VNDEVRYPRFLSLEAIAVMRRLLRKNPERRLGSSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFV 1451
            ||||||||||||.|||.:||||||:||||||||:||||||||||.||||:.||.||.|::.||||
Mouse   837 VNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSTERDAEDVKKQPFFRSLGWDVLLARRLPPPFV 901

  Fly  1452 PTINHLEDVSNFDEEFTSEKAQLTPPKEPRHLTEEEQLLFQDFSYTA 1498
            ||::...||||||||||.|...|:||::.|.||..||..|:||.:.|
Mouse   902 PTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFRDFDFVA 948

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012	31/63 (49%)
		HR1_PKN_2	243..309	CDD:212013	35/67 (52%)
		HR1_PKN_3	340..414	CDD:212015	38/73 (52%)
		C2	530..611	CDD:472691	45/80 (56%)
		STKc_PKN	1174..1499	CDD:270741	251/325 (77%)
Pkn1	NP_001186522.1	HR1_PKN_1	37..103	CDD:212012	31/65 (48%)
		HR1_PKN1_2	126..197	CDD:212020	36/71 (51%)
		HR1	214..286	CDD:469609	39/83 (47%)
		C2_PKN-like	397..484	CDD:176069	49/86 (57%)
		STKc_PKN	624..948	CDD:270741	250/323 (77%)