DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pkn and Pkn1

DIOPT Version :9

Sequence 1:NP_001097237.1 Gene:Pkn / 35950 FlyBaseID:FBgn0020621 Length:1501 Species:Drosophila melanogaster
Sequence 2:NP_001186522.1 Gene:Pkn1 / 320795 MGIID:108022 Length:951 Species:Mus musculus


Alignment Length:1412 Identity:520/1412 - (36%)
Similarity:670/1412 - (47%) Gaps:485/1412 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   101 EGEYIKHPVLYELSHKYGFT-ENLPESCMSIRLEEIKEAIRREIRKELKIKEGAEKLREVAKD-R 163
            :.|....|..:.|..:.|.. .:|....:..:||..:|.::||||||||:|||||.||....| .
Mouse     8 DSELESEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLKREIRKELKLKEGAENLRRATTDLG 72

  Fly   164 RSLSDVAVLVKKSKSKLAELKSELQELESQILLTSANTAVNSNGQESITACIDPNGGFLVSGAVG 228
            |||:.|.:|::.|..:|..|..:||||.:.::|.                  ||..|        
Mouse    73 RSLAPVELLLRGSARRLDLLHQQLQELHAHVVLP------------------DPAAG-------- 111

  Fly   229 GLGGGNTALEGGAP--ATANDKVLASLEKQLQIEMKVKTGAENMIQ--SLGIGCDKKLLAEAHQM 289
              .....:|..|:|  ::.|...:|.|||||.||:|||.|||||||  |.|...|:|||..|.||
Mouse   112 --SDATQSLAEGSPICSSTNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSSKDRKLLLTAQQM 174

  Fly   290 LADSKAKIEFLRLRIIKVKQNREQADRLKASRQMIDEHGQTIGGNNSSQPQSLETTLEERIEELR 354
            |.|||.||:.:|:::.:..| ..||..|::.....:..|....|           .:|.||||||
Mouse   175 LQDSKTKIDIIRMQLRRALQ-ALQAGELESQAAPDEAQGDPELG-----------AVELRIEELR 227

  Fly   355 HRLRIEAAVVDGAKNVIRTLQTANRAPDKKALQEAHGRLSESSRKLDLLRYSLDLRRQELPADSP 419
            |..|:|.||.:|||||:|.|..| :|||:||:.||..:|:||::||.|||.||:.|..|||||.|
Mouse   228 HHFRVEHAVAEGAKNVLRLLSGA-KAPDRKAVSEAQEKLTESNQKLGLLRESLERRLGELPADHP 291

  Fly   420 AAQQLKTELQIVQLSTSPAPVTYTSLQSGQAGILGGKPYQSVSSLGRCASVTGKLEVRLLGCQDL 484
            ..:.|:.||            |..|..:..|.:.|..|....|:|.:.|.:||.||||::||::|
Mouse   292 KGRLLREEL------------TAASSSAFSAILPGPFPATHYSTLSKPAPLTGTLEVRVVGCKNL 344

  Fly   485 LEDVPGRSRRDKDNNSSPGDLRSFV----KGVTSRSSS----KSYSVKDETSIEIMAVIKLDNIT 541
            .|.:|.........:.:|.....|:    :|:.|||.|    .|...:.|.:.|:..|:||||..
Mouse   345 PETIPWSPPPSVGASGTPESRTPFLSRPARGLYSRSGSLSGRSSLRGEAENATEVSTVLKLDNTV 409

  Fly   542 VGQTSWKQCSQQAWDQRFSIDLDRSRELEIGVYWRDWRSLCAVKVLRLEEFIDDVRHGMALQLEP 606
            ||||:||.|...||||.|:::|:|:||||:.|:|||.|.|||:|.|:||:|:|:.||.:.|.:||
Mouse   410 VGQTAWKPCGPNAWDQSFTLELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEP 474

  Fly   607 QGLLFAEVKFLNPMISQKPKLRRQRMIFNRQQAKNISRAKQMNINVATWGRLLKRNAPNHVHMGS 671
            ||.|.|||.|.||:|.:.|:|:||:.||::||.|...||:||||:||||.|||:|..|:.|..|:
Mouse   475 QGCLVAEVTFRNPIIERIPRLQRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPSAVATGT 539

  Fly   672 AGSGSSLTGSSPMVVGGSRDSESPISRTPSSDALVEPEPYTPGEQAQNLEFDPDAGINEHVETPG 736
                                                              |.|:|.         
Mouse   540 --------------------------------------------------FSPNAS--------- 545

  Fly   737 EYPDPAASGLSGMRPLSMHMQGISVLPPESPPVATGAAGRPNTLSLQMPGASKGQVIQGGRTAAP 801
                                                            |||              
Mouse   546 ------------------------------------------------PGA-------------- 548

  Fly   802 TTAPPPPPVLKATSTTPILDQELQDALHEFDFLSDLDSRPTTLRRLLKEQKMALDAGALENLLLQ 866
                                    :..|..|               :..:|:.|.|.:       
Mouse   549 ------------------------EIRHTGD---------------ISMEKLNLGADS------- 567

  Fly   867 QQQTEQQALQQRQRQEQLRLQQFQEAQRQAILDLCVKQREPAEQTSPTLANQTPTFPPLASNQIM 931
                                                   :.:.|.||                  
Mouse   568 ---------------------------------------DSSSQKSP------------------ 575

  Fly   932 PSLNARPCQSQSPNHNEFQLQPQPPHPAQKPTNPEPPSAVEQQLHRPVLILPPVVLLGGREEDRS 996
            |.|.:..|...||.|             :..|:||.||..::                       
Mouse   576 PGLPSTSCSLSSPTH-------------ESTTSPELPSETQE----------------------- 604

  Fly   997 VPPSPLVEYPEDDDEYLYRGSNENLGTRLHSSHSSSAGDRFCVEVIPQLGKLYVGSSQQQYAQQS 1061
                                               :.|...|                       
Mouse   605 -----------------------------------TPGPGLC----------------------- 611

  Fly  1062 SPIIQEPATPTIYGNSAAAGAPQFPQPAQRQEKQPPQQQPIYANQYELNVAKAAAAASVYSPSSS 1126
            ||:.:.|                                                          
Mouse   612 SPLRKSP---------------------------------------------------------- 618

  Fly  1127 TTSNSNQQQQQQRRNVARGLQYRESGGLETGRAGKQPPNAGMLSMDNFRLLSVLGRGHFGKVILS 1191
                                                      |::::|:.|:||||||||||:||
Mouse   619 ------------------------------------------LTLEDFKFLAVLGRGHFGKVLLS 641

  Fly  1192 QLRSNNQYYAIKALKKGDIIARDEVESLLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEY 1256
            :.||:.:.:||||||||||:||||||||:.||||........|||||||:.||||.:||||||||
Mouse   642 EFRSSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTRAGHPFLVNLFGCFQTPEHVCFVMEY 706

  Fly  1257 AAGGDLMMHIHTDVFLEPRAVFYAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLC 1321
            :||||||:|||:|||.|||||||:||||||||:|||:||:|||||||||||||||||||||||||
Mouse   707 SAGGDLMLHIHSDVFSEPRAVFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLC 771

  Fly  1322 KEGMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSI 1386
            |||||:||||.|||||||||||||||:|||||||||||||||::|||||||||||||||||||||
Mouse   772 KEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSI 836

  Fly  1387 VNDEVRYPRFLSLEAIAVMRRLLRKNPERRLGSSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFV 1451
            ||||||||||||.|||.:||||||:||||||||:||||||||||.||||:.||.||.|::.||||
Mouse   837 VNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSTERDAEDVKKQPFFRSLGWDVLLARRLPPPFV 901

  Fly  1452 PTINHLEDVSNFDEEFTSEKAQLTPPKEPRHLTEEEQLLFQDFSYTA 1498
            ||::...||||||||||.|...|:||::.|.||..||..|:||.:.|
Mouse   902 PTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFRDFDFVA 948

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PknNP_001097237.1 HR1_PKN_1 131..194 CDD:212012 31/63 (49%)
HR1_PKN_2 243..309 CDD:212013 35/67 (52%)
HR1_PKN_3 340..414 CDD:212015 38/73 (52%)
C2 530..611 CDD:301316 45/80 (56%)
STKc_PKN 1174..1499 CDD:270741 251/325 (77%)
S_TKc 1174..1433 CDD:214567 213/258 (83%)
Pkn1NP_001186522.1 HR1_PKN_1 37..103 CDD:212012 31/65 (48%)
HR1_PKN1_2 126..197 CDD:212020 36/71 (51%)
HR1 214..286 CDD:381797 39/83 (47%)
C2_PKN-like 397..484 CDD:176069 49/86 (57%)
STKc_PKN 624..948 CDD:270741 250/323 (77%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167839319
Domainoid 1 1.000 460 1.000 Domainoid score I486
eggNOG 1 0.900 - - E1_KOG0694
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 899 1.000 Inparanoid score I382
Isobase 1 0.950 - 0 Normalized mean entropy S1945
OMA 1 1.010 - - QHG49182
OrthoDB 1 1.010 - - D241576at33208
OrthoFinder 1 1.000 - - FOG0001458
OrthoInspector 1 1.000 - - otm43267
orthoMCL 1 0.900 - - OOG6_103771
Panther 1 1.100 - - O PTHR24356
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R891
SonicParanoid 1 1.000 - - X914
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1615.750

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