Protein Alignment Pkn and Pkn1

DIOPT Version :10

• Sequence 1: NP_001097237.1
• Gene: Pkn / 35950
• FlyBaseID: FBgn0020621
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: XP_006255307.1
• Gene: Pkn1 / 29355
• RGDID: 69308
• Length: 951
• Species: Rattus norvegicus
• Alignment Length: 1381
• Identity: 512/1381 - (37%)
• Similarity: 665/1381 - (48%)
• Gaps: 484/1381 - (35%)

  Fly   131 RLEEIKEAIRREIRKELKIKEGAEKLREVAKD-RRSLSDVAVLVKKSKSKLAELKSELQELESQI 194
            :||..:|.::||||||||:|||||.||....| .|||:.|.:|::.|..:|..|..:||||.:.:
  Rat    39 QLELERERLKREIRKELKLKEGAENLRRATTDLGRSLAPVELLLRGSARRLDLLHQQLQELHAHV 103

  Fly   195 LLTSANTAVNSNGQESITACIDPNGGFLVSGAVGGLGGGNTALEGGAP--ATANDKVLASLEKQL 257
            :|.                  ||..|          .....:|..|:|  ::.|...:|.|||||
  Rat   104 VLP------------------DPTAG----------SDAPQSLAEGSPVCSSTNLSRVAGLEKQL 140

  Fly   258 QIEMKVKTGAENMIQSLGIGC--DKKLLAEAHQMLADSKAKIEFLRLRIIKVKQNREQADRLKAS 320
            .||:|||.|||||||:...|.  |:|||..|.|||.|||.||:.:|:::.:..| ..||.:|::.
  Rat   141 AIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLRRALQ-ALQAGQLESQ 204

  Fly   321 RQMIDEHGQTIGGNNSSQPQSLETTLEERIEELRHRLRIEAAVVDGAKNVIRTLQTANRAPDKKA 385
            ....:.||....|           .:|.|||||||..|:|.||.:|||||:|.|..| :|||:||
  Rat   205 AAPDEAHGDPDLG-----------AVELRIEELRHHFRVEHAVAEGAKNVLRLLSAA-KAPDRKA 257

  Fly   386 LQEAHGRLSESSRKLDLLRYSLDLRRQELPADSPAAQQLKTELQIVQLSTSPAPVTYTSLQSGQA 450
            :.||..:|:||::||.|||.||:.|..|||||.|..:.|:.||      |:.:...::::
  Rat   258 VSEAQEKLTESNQKLGLLRESLERRLGELPADHPKGRLLREEL------TAASSAAFSAI----- 311

  Fly   451 GILGGKPYQSVSSLGRCASVTGKLEVRLLGCQDLLEDVPGRSRRDKDNNSSPGDLRSFV----KG 511
             :.|..|....|:|.:.|.:||.||||::||::|.|.:|.........:.:|.....|:    :|
  Rat   312 -LPGPFPATHYSTLSKPAPLTGTLEVRVVGCKNLPETIPWSPPPSVGASGTPDSRTPFLSRPARG 375

  Fly   512 VTSRSSSKS--YSVKD--ETSIEIMAVIKLDNITVGQTSWKQCSQQAWDQRFSIDLDRSRELEIG 572
            :.:||.|.|  .|:|.  |.|.|:..|:||||..||||:||.|...||||.|:::|:|:||||:.
  Rat   376 LYNRSGSLSGRSSLKGEAENSTEVSTVLKLDNTVVGQTAWKPCGPNAWDQSFTLELERARELELA 440

  Fly   573 VYWRDWRSLCAVKVLRLEEFIDDVRHGMALQLEPQGLLFAEVKFLNPMISQKPKLRRQRMIFNRQ 637
            |:|||.|.|||:|.|:||:|:|:.||.:.|.:||||.|.|||.|.||:|.:.|:|:||:.||::|
  Rat   441 VFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAEVTFRNPIIERIPRLQRQKKIFSKQ 505

  Fly   638 QAKNISRAKQMNINVATWGRLLKRNAPNHVHMGSAGSGSSLTGSSPMVVGGSRDSESPISRTPSS 702
            |.:...||:||||:||||.|||:|..||.|..||
  Rat   506 QGQTFQRARQMNIDVATWVRLLRRLIPNAVATGS------------------------------- 539

  Fly   703 DALVEPEPYTPGEQAQNLEFDPDAGINEHVETPGEYPDPAASGLSGMRPLSMHMQGISVLPPESP 767
                               |.|:|.....:.:.|:              :||....:.
  Rat   540 -------------------FSPNASPGSEIRSTGD--------------ISMEKLNLG------- 564

  Fly   768 PVATGAAGRPNTLSLQMPGASKGQVIQGGRTAAPTTAPPPPPVLKATSTTPILDQELQDALHEFD 832
                                                                             
  Rat   565 ----------------------------------------------------------------- 564

  Fly   833 FLSDLDSRPTTLRRLLKEQKMALDAGALENLLLQQQQTEQQALQQRQRQEQLRLQQFQEAQRQAI 897
              :|.||.
  Rat   565 --ADSDSS--------------------------------------------------------- 570

  Fly   898 LDLCVKQREPAEQTSPTLANQTPTFPPLASNQIMPSLNARPCQSQSPNHNEFQLQPQPPHPAQKP 962
                 .|:.||.                     :||.:   |...||.|             :..
  Rat   571 -----SQKSPAG---------------------LPSTS---CSLSSPTH-------------EST 593

  Fly   963 TNPEPPSAVEQQLHRPVLILPPVVLLGGREEDRSVPPSPLVEYPEDDDEYLYRGSNENLGTRLHS 1027
            |:||.||..::
  Rat   594 TSPELPSETQE------------------------------------------------------ 604

  Fly  1028 SHSSSAGDRFCVEVIPQLGKLYVGSSQQQYAQQSSPIIQEPATPTIYGNSAAAGAPQFPQPAQRQ 1092
                :.|...|                       ||:.:.|
  Rat   605 ----TPGPGLC-----------------------SPLRKSP------------------------ 618

  Fly  1093 EKQPPQQQPIYANQYELNVAKAAAAASVYSPSSSTTSNSNQQQQQQRRNVARGLQYRESGGLETG 1157
                                                                             
  Rat   619 ----------------------------------------------------------------- 618

  Fly  1158 RAGKQPPNAGMLSMDNFRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVESLLSE 1222
                       |::::|:.|:||||||||||:||:..|:.:.:||||||||||:||||||||:.|
  Rat   619 -----------LTLEDFKFLAVLGRGHFGKVLLSEFHSSGELFAIKALKKGDIVARDEVESLMCE 672

  Fly  1223 KRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIHTDVFLEPRAVFYAACVVLGL 1287
            |||........|||||||:.||||.:||||||||:||||||:|||:|||.|||||||:|||||||
  Rat   673 KRILATVTRAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAVFYSACVVLGL 737

  Fly  1288 QYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPEFLAPEVLTETSYT 1352
            |:|||:||:||||||||||||||||||||||||||||||:||||.|||||||||||||||:||||
  Rat   738 QFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYT 802

  Fly  1353 RAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRRLLRKNPERRL 1417
            |||||||||||::|||||||||||||||||||||||||||||||||.|||.:||||||:||||||
  Rat   803 RAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRL 867

  Fly  1418 GSSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLTPPKEPRH 1482
            ||:||||||||||.|||::.||.||.|::.||||||::...||||||||||.|...|:||::.|.
  Rat   868 GSTERDAEDVKKQPFFRTLDWDALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARP 932

  Fly  1483 LTEEEQLLFQDFSYTA 1498
            ||..||..|:||.:.|
  Rat   933 LTAAEQAAFRDFDFVA 948

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012	31/63 (49%)
		HR1_PKN_2	243..309	CDD:212013	34/67 (51%)
		HR1_PKN_3	340..414	CDD:212015	38/73 (52%)
		C2	530..611	CDD:472691	45/80 (56%)
		STKc_PKN	1174..1499	CDD:270741	249/325 (77%)
Pkn1	XP_006255307.1	HR1_PKN_1	37..103	CDD:212012	31/63 (49%)
		HR1_PKN1_2	126..197	CDD:212020	35/71 (49%)
		HR1	214..286	CDD:469609	39/83 (47%)
		C2_PKN-like	397..484	CDD:176069	49/86 (57%)
		STKc_PKN	624..948	CDD:270741	248/323 (77%)