DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pkn and pck2

DIOPT Version :9

Sequence 1:NP_001097237.1 Gene:Pkn / 35950 FlyBaseID:FBgn0020621 Length:1501 Species:Drosophila melanogaster
Sequence 2:NP_595950.1 Gene:pck2 / 2539649 PomBaseID:SPBC12D12.04c Length:1016 Species:Schizosaccharomyces pombe


Alignment Length:1346 Identity:333/1346 - (24%)
Similarity:536/1346 - (39%) Gaps:437/1346 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   247 DKVLASLEKQLQIEMKVKTGAENMIQSLGIGCDKKLL------AEAHQMLADSKAKIEFLRLRII 305
            |:.:..:.::::.|..|..||.:|         |:|.      .:.|..:.:||..|.:|..|:.
pombe     5 DEAITEVVRKIERERSVIHGALSM---------KRLTQNQTVHQQLHSNIEESKKSIIYLEERLE 60

  Fly   306 KVKQNREQADRLKASRQMI----------DEHGQTIGGNNSSQPQSLE----------TTLEERI 350
            |:|..:....:..:.:..:          .:..::....:|:...:|:          :.:...:
pombe    61 KLKLRKNGVRKSNSEKPSVGIEKNPSFSTTKSAKSFSSTSSNIDSNLDLLNYDTPLTISKISFLL 125

  Fly   351 EELRHRLRIEAAVVDGAKNVIRTLQTANRAPDKKALQEAHGRLSESSRKLDLLRYSLDLRRQELP 415
            ::|..:|.:|.....|.:.:.:..:   |..|::::.||..:..||::|:.||:.:|        
pombe   126 QQLEFKLSVEEQYRKGIEKMAKLYE---REHDRRSIAEAEKKYVESAQKITLLKQAL-------- 179

  Fly   416 ADSPAAQQLKTELQIVQLSTSPAPVTYTSLQSGQAGILGGKPYQSVSSLGRCASVTGKLEVRLLG 480
                                                    |.|..:           .:|:.   
pombe   180 ----------------------------------------KRYHDL-----------HIEID--- 190

  Fly   481 CQDLLEDVPGRSRRDKDNNSSP--GDLRSFVKGVTSRSSSKSYSVKDETSIEIMAVIKLDNITVG 543
                .||||....|...|...|  |.|:..|..:  |:.:.|..:..:|  |::..|:.:::...
pombe   191 ----EEDVPSTESRGNLNARRPQSGLLKITVGSL--RNVTHSAGISKQT--EMIVAIRAEDLERA 247

  Fly   544 QTSWKQCSQQAWDQRFSIDLDRSRELEIGVYWRDWRSLCAVKVLRLEEFIDDVRHGMALQLEPQG 608
            :|  :......:::.|.|||:::.|:||.||.:....|                      |.|.|
pombe   248 RT--RPSRTDRFNETFEIDLEKTNEVEIVVYEKKNEKL----------------------LLPVG 288

  Fly   609 LLFAEVKFLNPMISQKPKLRRQRMIFNRQQAKNISRAKQMNINVATWGRLLKRNAPNHVHMGSAG 673
            ||:..   |:.::.   |.||:::              :..::...|                  
pombe   289 LLWIR---LSDLVE---KQRRKKV--------------EQEVSDKGW------------------ 315

  Fly   674 SGSSLTGSSPMVVGGSRDSESPISRTPSSDALVEPEPYTPGEQAQNLEFDPDAGINEHVETPGEY 738
                                      .|:|.::.          |.|.....:.:|         
pombe   316 --------------------------VSADKMIN----------QRLSIFLPSALN--------- 335

  Fly   739 PDPAASGLSGMRPLSMHMQGISVLPPESPPVATGAAGRPNTLSLQMPGASKGQVIQGGRTAAPTT 803
                                 ::..|||       ..||||       ||..|.:....:..|  
pombe   336 ---------------------NISKPES-------TDRPNT-------ASGNQSVSAWFSLEP-- 363

  Fly   804 APPPPPVLKATSTTPILDQELQDALHEFDFLSDLDSRPTTLRRLLKEQKMALDAGALENLLLQQQ 868
                                    :.:.:...:.....|        :|..:|||.         
pombe   364 ------------------------MGQINLTMNFTKHNT--------RKRPMDAGL--------- 387

  Fly   869 QTEQQALQQRQRQEQLR-------LQ-QFQEAQRQAILDLCVKQREPAEQTSPTLANQTPTFPPL 925
             ..|.|:  |||:|.:.       || ||.:..|.|:....:|.....:............:|.:
pombe   388 -GRQGAI--RQRKESVHEVYGHKFLQHQFYQIMRCALCGEFLKNAAGMQCIDCHYTCHKKCYPKV 449

  Fly   926 ASNQIMPSLNARPCQSQSPNHNEFQLQPQPPHPAQKPTNPEPPSAVEQQLHRPVLILPPVVLLGG 990
            .:..|..|.::...:.:..||       :.||..:..||    .......|...::  |:    |
pombe   450 VTKCISKSSDSASSEYEKINH-------RIPHHFESHTN----IGANWCCHCGYIL--PL----G 497

  Fly   991 REEDRSVPPSPLVEYPEDDDEYLYRGSNENLGTRLHSSHSSSAGDRFCVEVIP------------ 1043
            |:..|..                     ...|...|:.         ||.::|            
pombe   498 RKTARKC---------------------TECGITAHAQ---------CVHLVPDFCGMSMEMANR 532

  Fly  1044 -----QLGKLYVGSSQQQYAQQS------------------------SPIIQEPATPTIYGNSAA 1079
                 :..|:|   ..||:.|:|                        |..|....||:|   :.|
pombe   533 VISEIRTTKIY---KAQQHKQKSSHHKHHHHKKSKSSSSKHKENDKASVSITTTTTPSI---TPA 591

  Fly  1080 AGAPQFPQPAQRQEKQPPQQQPIYANQYELNVA---KAAAAASVYS-------------PSSSTT 1128
            ...|..|:|.   ..:|.:::|::|...|:...   |..|...|..             ||....
pombe   592 DPVPTSPKPL---AIEPVKRKPVHAGNLEVTSVSDNKLGATVQVVEQKVDDKADALTKPPSLDAV 653

  Fly  1129 SNSNQQQQQQRRNVARGLQYRESGGLETGRAGKQPPNAGMLSMDNFRLLSVLGRGHFGKVILSQL 1193
            .........:...||:.|.::                |..:.:::|..|||||:|:||||:|::|
pombe   654 KEPIPVPSVETSVVAQDLTHK----------------AKRIGLEDFTFLSVLGKGNFGKVMLAEL 702

  Fly  1194 RSNNQYYAIKALKKGDIIARDEVESLLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAA 1258
            :|..|.||||.|||..|:..|||||..||||:|.|||..||||||||:||||||..:.|||::.:
pombe   703 KSEKQLYAIKVLKKEFILENDEVESTKSEKRVFLVANRERHPFLVNLHSCFQTETRIYFVMDFVS 767

  Fly  1259 GGDLMMHIHTDVFLEPRAVFYAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKE 1323
            |||||:||..:.|...||.||||.|.|.|:|.|:|.||||||||||:||..:|:||:||:|||||
pombe   768 GGDLMLHIQQEQFSRRRAQFYAAEVCLALKYFHDNGIIYRDLKLDNILLSPDGHVKVADYGLCKE 832

  Fly  1324 GMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVN 1388
            .|...:.|.||||||||:|||:|.|..|||:||||..||||::||:|:|||.|:||||:||:|::
pombe   833 DMWHDNTTATFCGTPEFMAPEILLEQQYTRSVDWWAFGVLIYQMLLGQSPFRGEDEEEIFDAILS 897

  Fly  1389 DEVRYPRFLSLEAIAVMRRLLRKNPERRLGSSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPT 1453
            ||..||..:..::::::::||.::|::||||...|||||....||.:|.|||:..::.:||::|:
pombe   898 DEPLYPIHMPRDSVSILQQLLTRDPKKRLGSGPNDAEDVMTHPFFSNINWDDIYHKRTQPPYIPS 962

  Fly  1454 INHLEDVSNFDEEFTSEKAQLTPPKEPRHLTEEEQLLFQDFSYTAE 1499
            :|...|...||||||.|...|||...  .||:|.|..|:.|||:.|
pombe   963 LNSPTDTKYFDEEFTRELPVLTPVNS--ILTKEMQQHFEGFSYSCE 1006

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PknNP_001097237.1 HR1_PKN_1 131..194 CDD:212012
HR1_PKN_2 243..309 CDD:212013 15/67 (22%)
HR1_PKN_3 340..414 CDD:212015 15/83 (18%)
C2 530..611 CDD:301316 17/80 (21%)
STKc_PKN 1174..1499 CDD:270741 180/324 (56%)
S_TKc 1174..1433 CDD:214567 151/258 (59%)
pck2NP_595950.1 HR1_PKC-like_1_fungi 2..73 CDD:212011 16/76 (21%)
HR1_PKC-like_2_fungi 115..186 CDD:212010 16/132 (12%)
C2_fungal_Pkc1p 213..320 CDD:176071 29/198 (15%)
C1_1 406..454 CDD:278556 8/47 (17%)
C1_1 474..526 CDD:278556 13/91 (14%)
S_TKc 683..942 CDD:214567 151/258 (59%)
STKc_PKC 688..1003 CDD:270722 175/316 (55%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 322 1.000 Domainoid score I226
eggNOG 1 0.900 - - E1_KOG0694
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24356
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R891
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.940

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