Protein Alignment Pkn and Pkn2

DIOPT Version :10

• Sequence 1: NP_001097237.1
• Gene: Pkn / 35950
• FlyBaseID: FBgn0020621
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_001099225.2
• Gene: Pkn2 / 207122
• RGDID: 620146
• Length: 983
• Species: Rattus norvegicus
• Alignment Length: 1412
• Identity: 573/1412 - (40%)
• Similarity: 725/1412 - (51%)
• Gaps: 458/1412 - (32%)

  Fly   109 VLYEL---SHKYGFTENL--------PESCMSIRLEEIKEAIRREIRKELKIKEGAEKLREVAKD 162
            :|.||   |....|:||:        .::.:..:|:::|:.|:||||||||||||||.||:|..|
  Rat    11 LLTELQGDSRPLPFSENVSAVQKLDFSDTIVQQKLDDVKDRIKREIRKELKIKEGAENLRKVTTD 75

  Fly   163 RRSLSDVAVLVKKSKSKLAELKSELQELESQILLTSANTAVNSNGQESITACIDPNGGFLVSGAV 227
            :::|:.|..::|||..||.||..:||||.:.|::        |:.::|......|
  Rat    76 KKNLAYVDNILKKSNKKLEELHHKLQELNAHIVV--------SDPEDSADCPRTP---------- 122

  Fly   228 GGLGGGNTALEGGAPATANDKVLASLEKQLQIEMKVKTGAENMIQ--SLGIGCDKKLLAEAHQML 290
                  :|.......:|:|::::| |:|||.||:|||.|||||||  |.|...|:||...|.|:|
  Rat   123 ------DTPNSDSRSSTSNNRLMA-LQKQLDIELKVKQGAENMIQMYSNGPSKDRKLHGTAQQLL 180

  Fly   291 ADSKAKIEFLRLRIIKVKQNREQA-DRLKASRQMIDEHGQTIGGNNSSQPQSLETTLEERIEELR 354
            .|||.|||.:|::|::..|..|.| |..|                      .:.:.||.|:||||
  Rat   181 QDSKTKIEVIRMQILQAVQTNELAFDNAK----------------------PVISPLELRMEELR 223

  Fly   355 HRLRIEAAVVDGAKNVIRTLQTANRAPDKKALQEAHGRLSESSRKLDLLRYSLDLRRQELPADSP 419
            |..|||.||.:|||||::.| .:.:..|:|||.||..|.:|||:|||||:|||:.|..|||.:.|
  Rat   224 HHFRIEFAVAEGAKNVMKLL-GSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNELPKNHP 287

  Fly   420 AAQQLKTELQIVQLSTSPAPVTYTSLQSGQAGILGGKPYQSVSSLGRCASVTGKLEVRLLGCQDL 484
            .:..:..||.:|   .||......|:.|.|         ...|:|.:.|::||.|||||:||||:
  Rat   288 KSSVVIEELSLV---ASPTLSPRQSMLSTQ---------NQYSTLSKPAALTGTLEVRLMGCQDI 340

  Fly   485 LEDVPGRSRRDKD--NNSSPGDLRSFVKGVTSRS---SSKSYSVKDETSIEIMAVIKLDNITVGQ 544
            ||:|||||:....  ...||.:.||.....||:|   ||::....|:.|.::.||:||||..|||
  Rat   341 LENVPGRSKATSVALPGWSPSENRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQ 405

  Fly   545 TSWKQCSQQAWDQRFSIDLDRSRELEIGVYWRDWRSLCAVKVLRLEEFIDDVRHGMALQLEPQGL 609
            |.||..|.|:|||:|:::|||||||||.|||||||||||||.||||:|:|:.||||.|.|||||.
  Rat   406 TIWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGT 470

  Fly   610 LFAEVKFLNPMISQKPKLRRQRMIFNRQQAKNISRAKQMNINVATWGRLLKRNAPNHVHMGSAGS 674
            |||||.|.||:|.::|||:||:.||::||.|...||.|||||:||||||::|..|...|.|:...
  Rat   471 LFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSP 535

  Fly   675 GSSLTGSSPMVVGGSRDSESPISRTPSSDALVEPEPYTPGEQAQNLEFDPDAGINEHVETPGEYP 739
            .:.:..:.|:|     |:.:|....|:||:.|           ..|:||
  Rat   536 QTPVPATVPVV-----DARTPELAPPASDSTV-----------TKLDFD---------------- 568

  Fly   740 DPAASGLSGMRPLSMHMQGISVLPPESPPVATGAAGRPNTLSLQMPGASKGQVIQGGRTAAPTTA 804
                                  |.||:||                                   |
  Rat   569 ----------------------LEPEAPP-----------------------------------A 576

  Fly   805 PPPPPVLKATSTTPILDQELQDALHEFDFLSDLDSRPTTLRRLLKEQKMALDAGALENLLLQQQQ 869
            ||     :|:|            |.|.|..|:|
  Rat   577 PP-----RASS------------LGEIDDSSEL-------------------------------- 592

  Fly   870 TEQQALQQRQRQEQLRLQQFQEAQRQAILDLCVKQREPAEQTSPTLANQTPTFPPLASNQIMPSL 934
                                      .:||:                      |...|..:....
  Rat   593 --------------------------RVLDI----------------------PGQGSETVFDIE 609

  Fly   935 NARPCQSQSPNHNEFQLQPQPPHPAQKPTNPEPPSAVEQQLHRPVLILPPVVLLGGREEDRSVPP 999
            |.|                         .|..|.|..|.:|                    ::|.
  Rat   610 NDR-------------------------NNMRPKSKSEYEL--------------------NIPD 629

  Fly  1000 SPLVEYPEDDDEYLYRGSNENLGTRLHSSHSSSAGDRFCVEVIPQLGKLYVGSSQQQYAQQSSPI 1064
            |                                  .|.|..|    |:|....|||::
  Rat   630 S----------------------------------SRSCWSV----GELEDKRSQQRF------- 649

  Fly  1065 IQEPATPTIYGNSAAAGAPQFPQPAQRQEKQPPQQQPIYANQYELNVAKAAAAASVYSPSSSTTS 1129
                               ||
  Rat   650 -------------------QF-------------------------------------------- 651

  Fly  1130 NSNQQQQQQRRNVARGLQYRESGGLETGRAGKQPPNAGMLSMDNFRLLSVLGRGHFGKVILSQLR 1194
                                                    ::.:||..:||||||||||:|::.:
  Rat   652 ----------------------------------------NLQDFRCCAVLGRGHFGKVLLAEYK 676

  Fly  1195 SNNQYYAIKALKKGDIIARDEVESLLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAAG 1259
            ..|:.:||||||||||:|||||:||:.||||||..|::||||||||::||||::|||||||||||
  Rat   677 HTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAG 741

  Fly  1260 GDLMMHIHTDVFLEPRAVFYAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKEG 1324
            ||||||||||||.||||||||||||||||||||:||:|||||||||||||||:||||||||||||
  Rat   742 GDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEG 806

  Fly  1325 MGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVND 1389
            ||:||||.||||||||||||||||||||||||||||||||:||||||||||||||||||||||||
  Rat   807 MGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVND 871

  Fly  1390 EVRYPRFLSLEAIAVMRRLLRKNPERRLGSSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPTI 1454
            |||||||||.|||::||||||:|||||||:.|:|||||||..|||...|..||.:||||||||||
  Rat   872 EVRYPRFLSTEAISIMRRLLRRNPERRLGAGEKDAEDVKKHPFFRLTDWSALLDKKVKPPFVPTI 936

  Fly  1455 NHLEDVSNFDEEFTSEKAQLTPPKEPRHLTEEEQLLFQDFSYTAEWC 1501
            ...|||||||:|||||...||||:|||.|.||||.:|:||.|.|:||
  Rat   937 RGREDVSNFDDEFTSEAPILTPPREPRILLEEEQEMFRDFDYVADWC 983

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012	34/62 (55%)
		HR1_PKN_2	243..309	CDD:212013	35/67 (52%)
		HR1_PKN_3	340..414	CDD:212015	38/73 (52%)
		C2	530..611	CDD:472691	56/80 (70%)
		STKc_PKN	1174..1499	CDD:270741	261/324 (81%)
Pkn2	NP_001099225.2	HR1_PKN_1	42..107	CDD:212012	34/64 (53%)
		HR1_PKN2_2	128..201	CDD:212021	36/73 (49%)
		HR1_PKN2_3	209..282	CDD:212025	39/95 (41%)
		C2_PKN-like	389..472	CDD:176069	57/82 (70%)
		STKc_PKN	656..981	CDD:270741	261/324 (81%)