DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pkn and AKT1

DIOPT Version :10

Sequence 1:NP_001097237.1 Gene:Pkn / 35950 FlyBaseID:FBgn0020621 Length:1501 Species:Drosophila melanogaster
Sequence 2:NP_005154.2 Gene:AKT1 / 207 HGNCID:391 Length:480 Species:Homo sapiens


Alignment Length:377 Identity:167/377 - (44%)
Similarity:238/377 - (63%) Gaps:22/377 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly  1140 RNVARGLQYRESGGLETGRAGKQPPNAG-------------MLSMDNFRLLSVLGRGHFGKVILS 1191
            :.||.||:.:|...::. |:|....|:|             .::|:.|..|.:||:|.||||||.
Human   104 QTVADGLKKQEEEEMDF-RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILV 167

  Fly  1192 QLRSNNQYYAIKALKKGDIIARDEVESLLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEY 1256
            :.::..:|||:|.|||..|:|:|||...|:|.|:.:.:   |||||..|...|||...:||||||
Human   168 KEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS---RHPFLTALKYSFQTHDRLCFVMEY 229

  Fly  1257 AAGGDLMMHIHTD-VFLEPRAVFYAACVVLGLQYLH-ENKIIYRDLKLDNLLLDTEGYVKIADFG 1319
            |.||:|..|:..: ||.|.||.||.|.:|..|.||| |..::||||||:||:||.:|::||.|||
Human   230 ANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 294

  Fly  1320 LCKEGMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFD 1384
            |||||:..|....|||||||:||||||.:..|.||||||||||:::||:.|..||...|.|::|:
Human   295 LCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFE 359

  Fly  1385 SIVNDEVRYPRFLSLEAIAVMRRLLRKNPERRLGSSERDAEDVKKQAFFRSIVWDDLLLRKVKPP 1449
            .|:.:|:|:||.|..||.:::..||:|:|::|||....||:::.:..||..|||..:..:|:.||
Human   360 LILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPP 424

  Fly  1450 FVPTINHLEDVSNFDEEFTSEKAQLTPPKEPRHL---TEEEQLLFQDFSYTA 1498
            |.|.:....|...||||||::...:|||.:...:   ..|.:..|..|||:|
Human   425 FKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSA 476

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PknNP_001097237.1 HR1_PKN_1 131..194 CDD:212012
HR1_PKN_2 243..309 CDD:212013
HR1_PKN_3 340..414 CDD:212015
C2 530..611 CDD:472691
STKc_PKN 1174..1499 CDD:270741 157/330 (48%)
AKT1NP_005154.2 PH_PKB 4..111 CDD:269947 3/6 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 113..138 5/25 (20%)
STKc_PKB_alpha 124..479 CDD:270746 160/356 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 450..480 9/27 (33%)
Blue background indicates that the domain is not in the aligned region.

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