DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pkn and Prkcq

DIOPT Version :9

Sequence 1:NP_001097237.1 Gene:Pkn / 35950 FlyBaseID:FBgn0020621 Length:1501 Species:Drosophila melanogaster
Sequence 2:NP_032885.1 Gene:Prkcq / 18761 MGIID:97601 Length:707 Species:Mus musculus


Alignment Length:348 Identity:162/348 - (46%)
Similarity:228/348 - (65%) Gaps:18/348 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly  1159 AGKQPPNAGM--------LSMDNFRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDE 1215
            ||...|...|        |.:|:|.|..:||:|.||||.|::.:..||::|||||||..::..|:
Mouse   357 AGPPEPEVSMRRTSLQLKLKIDDFILHKMLGKGSFGKVFLAEFKRTNQFFAIKALKKDVVLMDDD 421

  Fly  1216 VESLLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIHT-DVFLEPRAVFY 1279
            ||..:.|||:..:  |..||||.:::..|||::::.|||||..|||||.||.: ..|...||.||
Mouse   422 VECTMVEKRVLSL--AWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFY 484

  Fly  1280 AACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGD-RTGTFCGTPEFLAP 1343
            ||.|:||||:||...|:||||||||:|||.:|::||||||:|||.| .|| :|.||||||:::||
Mouse   485 AAEVILGLQFLHSKGIVYRDLKLDNILLDRDGHIKIADFGMCKENM-LGDAKTNTFCGTPDYIAP 548

  Fly  1344 EVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRRL 1408
            |:|....|..:||||..|||::|||:|:|||.|.||||:|.||..|...|||:|..||..::.:|
Mouse   549 EILLGQKYNHSVDWWSFGVLVYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEREAKDLLVKL 613

  Fly  1409 LRKNPERRLGSSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQ 1473
            ..:.||:|||.    ..|:::...||.|.|::|..:::.|||.|.:....|.||||:||.|||.:
Mouse   614 FVREPEKRLGV----RGDIRQHPLFREINWEELERKEIDPPFRPKVKSPYDCSNFDKEFLSEKPR 674

  Fly  1474 LTPPKEPRHLTEEEQLLFQDFSY 1496
            |: ..:...:...:|.:|.:||:
Mouse   675 LS-FADRALINSMDQNMFSNFSF 696

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PknNP_001097237.1 HR1_PKN_1 131..194 CDD:212012
HR1_PKN_2 243..309 CDD:212013
HR1_PKN_3 340..414 CDD:212015
C2 530..611 CDD:301316
STKc_PKN 1174..1499 CDD:270741 156/325 (48%)
S_TKc 1174..1433 CDD:214567 132/260 (51%)
PrkcqNP_032885.1 C1_1 160..212 CDD:278556
C1_1 232..284 CDD:278556
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 327..365 3/7 (43%)
STKc_nPKC_theta 374..704 CDD:270770 158/331 (48%)
S_TKc 380..634 CDD:214567 132/260 (51%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0694
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R891
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.840

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