DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pkn and Prkci

DIOPT Version :10

Sequence 1:NP_001097237.1 Gene:Pkn / 35950 FlyBaseID:FBgn0020621 Length:1501 Species:Drosophila melanogaster
Sequence 2:NP_032883.2 Gene:Prkci / 18759 MGIID:99260 Length:595 Species:Mus musculus


Alignment Length:532 Identity:183/532 - (34%)
Similarity:273/532 - (51%) Gaps:73/532 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   997 VPPSPLVEYPEDDDEYLYRGSNENLGTRLHSSHSSSAGDRF--------CVEVIPQLGKLYVGSS 1053
            ||..|.:..|.:|.....||:.........:.|:..| .||        |.:.|..||:      
Mouse   109 VPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQA-KRFNRRAHCAICTDRIWGLGR------ 166

  Fly  1054 QQQYAQQSSPIIQEPATPTIYGNSAAAGAPQFPQPAQRQEKQPPQQQPIYANQYELNVAKAAAAA 1118
            |.........::.:.....:.........|..|.....|...|...|.:..              
Mouse   167 QGYKCINCKLLVHKKCHKLVTIECGRHSLPPEPMMPMDQTMHPDHTQTVIP-------------- 217

  Fly  1119 SVYSPSSSTTSNSNQQQQQQRRNVARGLQYRESGGLETGRAGKQPPNAGMLSMDNFRLLSVLGRG 1183
              |:|||..:.:...::::       .:..||||...:.           |.:.:|.||.|:|||
Mouse   218 --YNPSSHESLDQVGEEKE-------AMNTRESGKASSS-----------LGLQDFDLLRVIGRG 262

  Fly  1184 HFGKVILSQLRSNNQYYAIKALKKGDIIARDEVESLLSEKRIFEVANAMRHPFLVNLYSCFQTEQ 1248
            .:.||:|.:|:..::.||:|.:||..:...::::.:.:||.:||  .|..|||||.|:||||||.
Mouse   263 SYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFE--QASNHPFLVGLHSCFQTES 325

  Fly  1249 HVCFVMEYAAGGDLMMHIHTDVFL-EPRAVFYAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGY 1312
            .:.||:||..|||||.|:.....| |..|.||:|.:.|.|.||||..||||||||||:|||:||:
Mouse   326 RLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGH 390

  Fly  1313 VKIADFGLCKEGMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIFEMLVGESPF--- 1374
            :|:.|:|:||||:..||.|.||||||.::|||:|....|..:||||.||||:|||:.|.|||   
Mouse   391 IKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIV 455

  Fly  1375 -----PGDDEEE-VFDSIVNDEVRYPRFLSLEAIAVMRRLLRKNPERRLGSSERDA-EDVKKQAF 1432
                 |..:.|: :|..|:..::|.||.||::|.:|::..|.|:|:.|||...:.. .|::...|
Mouse   456 GSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPF 520

  Fly  1433 FRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLTPPKEP--RHLTEEEQLLFQDFS 1495
            ||::.||.:..::|.|||.|.|:....:.|||.:||:|..||||..:.  |.:.:.|   |:.|.
Mouse   521 FRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSE---FEGFE 582

  Fly  1496 Y------TAEWC 1501
            |      :||.|
Mouse   583 YINPLLMSAEEC 594

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PknNP_001097237.1 HR1_PKN_1 131..194 CDD:212012
HR1_PKN_2 243..309 CDD:212013
HR1_PKN_3 340..414 CDD:212015
C2 530..611 CDD:472691
STKc_PKN 1174..1499 CDD:270741 150/343 (44%)
PrkciNP_032883.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
Regulatory domain. /evidence=ECO:0000250 2..252 30/183 (16%)
Required for interaction with RAB2. /evidence=ECO:0000250 2..28
PB1_aPKC 26..108 CDD:99725
Interaction with PARD6A. /evidence=ECO:0000250 72..91
Pseudosubstrate 125..134 2/8 (25%)
C1_aPKC 139..193 CDD:410344 9/60 (15%)
STKc_aPKC_iota 232..595 CDD:270769 158/386 (41%)
Blue background indicates that the domain is not in the aligned region.

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