DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkn and Prkce

DIOPT Version :9

Sequence 1:	NP_001097237.1	Gene:	Pkn / 35950	FlyBaseID:	FBgn0020621	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	NP_035234.1	Gene:	Prkce / 18754	MGIID:	97599	Length:	737	Species:	Mus musculus

Alignment Length:	460	Identity:	191/460 - (41%)
Similarity:	275/460 - (59%)	Gaps:	65/460 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1070 TPTIYGNSA------AAGAPQFPQPAQRQEKQPPQQQPIYANQYELNVAKAAAAASVYSPS---- 1124
            ||....||.      |||| :.|||                             ||..|||
Mouse   309 TPDKITNSGQRRKKLAAGA-ESPQP-----------------------------ASGNSPSEDDR 343

  Fly  1125 --SSTTSNSNQQQQQQRRNVA-------RGLQYRESGGLE-----TGRAGK-QPPNAGMLSMDNF 1174
              |:.||..:|:.::...|:.       ||.::|.|...:     .|..|: :|..|..|.:|.|
Mouse   344 SKSAPTSPCDQELKELENNIRKALSFDNRGEEHRASSATDGQLASPGENGEVRPGQAKRLGLDEF 408

  Fly  1175 RLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVESLLSEKRIFEVANAMRHPFLVN 1239
            ..:.|||:|.||||:|::|:..::.||:|.|||..|:..|:|:..::||||  :|.|.:||:|..
Mouse   409 NFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRI--LALARKHPYLTQ 471

  Fly  1240 LYSCFQTEQHVCFVMEYAAGGDLMMHI-HTDVFLEPRAVFYAACVVLGLQYLHENKIIYRDLKLD 1303
            ||.||||:..:.|||||..|||||..| .:..|.|||:.||||.|...|.:||::.:||||||||
Mouse   472 LYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLD 536

  Fly  1304 NLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIFEML 1368
            |:|||.||:.|:||||:||||:..|..|.||||||:::|||:|.|..|..:||||.||||::||:
Mouse   537 NILLDAEGHCKLADFGMCKEGIMNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMM 601

  Fly  1369 VGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRRLLRKNPERRLGS-SERDAED-VKKQA 1431
            .|:.||..|:|:::|:||::|:|.||.:||.||:::::..:.|||.:|||. :.::.|| :|:..
Mouse   602 AGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVAAQNGEDAIKQHP 666

  Fly  1432 FFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLTPPKEP--RHLTEEEQLLFQDF 1494
            ||:.|.|..|..:|:||||.|.|....||:|||::||.|:..||...|.  :.:.:||   |:.|
Mouse   667 FFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPILTLVDEAIIKQINQEE---FKGF 728

  Fly  1495 SYTAE 1499
            ||..|
Mouse   729 SYFGE 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012
		HR1_PKN_2	243..309	CDD:212013
		HR1_PKN_3	340..414	CDD:212015
		C2	530..611	CDD:301316
		STKc_PKN	1174..1499	CDD:270741	159/329 (48%)
		S_TKc	1174..1433	CDD:214567	130/261 (50%)
Prkce	NP_035234.1	C2_PKC_epsilon	3..135	CDD:175981
		C1_1	170..220	CDD:278556
		Interaction with actin	223..228
		C1_1	243..295	CDD:278556
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	310..356		19/75 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..398		6/27 (22%)
		S_TKc	408..668	CDD:214567	130/261 (50%)
		STKc_nPKC_epsilon	412..732	CDD:270743	158/324 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839316
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0694
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.770