Protein Alignment Pkn and Prkce

DIOPT Version :10

• Sequence 1: NP_001097237.1
• Gene: Pkn / 35950
• FlyBaseID: FBgn0020621
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_035234.1
• Gene: Prkce / 18754
• MGIID: 97599
• Length: 737
• Species: Mus musculus
• Alignment Length: 460
• Identity: 191/460 - (41%)
• Similarity: 275/460 - (59%)
• Gaps: 65/460 - (14%)

  Fly  1070 TPTIYGNSA------AAGAPQFPQPAQRQEKQPPQQQPIYANQYELNVAKAAAAASVYSPS---- 1124
            ||....||.      |||| :.|||                             ||..|||
Mouse   309 TPDKITNSGQRRKKLAAGA-ESPQP-----------------------------ASGNSPSEDDR 343

  Fly  1125 --SSTTSNSNQQQQQQRRNVA-------RGLQYRESGGLE-----TGRAGK-QPPNAGMLSMDNF 1174
              |:.||..:|:.::...|:.       ||.::|.|...:     .|..|: :|..|..|.:|.|
Mouse   344 SKSAPTSPCDQELKELENNIRKALSFDNRGEEHRASSATDGQLASPGENGEVRPGQAKRLGLDEF 408

  Fly  1175 RLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVESLLSEKRIFEVANAMRHPFLVN 1239
            ..:.|||:|.||||:|::|:..::.||:|.|||..|:..|:|:..::||||  :|.|.:||:|..
Mouse   409 NFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRI--LALARKHPYLTQ 471

  Fly  1240 LYSCFQTEQHVCFVMEYAAGGDLMMHI-HTDVFLEPRAVFYAACVVLGLQYLHENKIIYRDLKLD 1303
            ||.||||:..:.|||||..|||||..| .:..|.|||:.||||.|...|.:||::.:||||||||
Mouse   472 LYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLD 536

  Fly  1304 NLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIFEML 1368
            |:|||.||:.|:||||:||||:..|..|.||||||:::|||:|.|..|..:||||.||||::||:
Mouse   537 NILLDAEGHCKLADFGMCKEGIMNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMM 601

  Fly  1369 VGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRRLLRKNPERRLGS-SERDAED-VKKQA 1431
            .|:.||..|:|:::|:||::|:|.||.:||.||:::::..:.|||.:|||. :.::.|| :|:..
Mouse   602 AGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVAAQNGEDAIKQHP 666

  Fly  1432 FFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLTPPKEP--RHLTEEEQLLFQDF 1494
            ||:.|.|..|..:|:||||.|.|....||:|||::||.|:..||...|.  :.:.:||   |:.|
Mouse   667 FFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPILTLVDEAIIKQINQEE---FKGF 728

  Fly  1495 SYTAE 1499
            ||..|
Mouse   729 SYFGE 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012
		HR1_PKN_2	243..309	CDD:212013
		HR1_PKN_3	340..414	CDD:212015
		C2	530..611	CDD:472691
		STKc_PKN	1174..1499	CDD:270741	159/329 (48%)
Prkce	NP_035234.1	C2_PKC_epsilon	3..135	CDD:175981
		C1_nPKC_epsilon-like_rpt1	161..224	CDD:410385
		Interaction with actin	223..228
		C1_nPKC_epsilon-like_rpt2	241..295	CDD:410388
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	310..356		19/75 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..398		6/27 (22%)
		STKc_nPKC_epsilon	412..732	CDD:270743	158/324 (49%)