DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkn and Prkca

DIOPT Version :9

Sequence 1:	NP_001097237.1	Gene:	Pkn / 35950	FlyBaseID:	FBgn0020621	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	XP_036012317.1	Gene:	Prkca / 18750	MGIID:	97595	Length:	688	Species:	Mus musculus

Alignment Length:	383	Identity:	166/383 - (43%)
Similarity:	231/383 - (60%)	Gaps:	39/383 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1150 ESGGLE---------TGRAG----------KQPP-NAGMLSMDNFRLLSVLGRGHFGKVILSQLR 1194
            |.|.:|         .|.||          |||. |...:.:.:|..|.|||:|.||||:|:..:
Mouse   295 EEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRK 359

  Fly  1195 SNNQYYAIKALKKGDIIARDEVESLLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAAG 1259
            ...:.||||.|||..:|..|:||..:.|||:..:.:  :.|||..|:|||||...:.|||||..|
Mouse   360 GTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLD--KPPFLTQLHSCFQTVDRLYFVMEYVNG 422

  Fly  1260 GDLMMHI-HTDVFLEPRAVFYAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKE 1323
            ||||.|| ....|.||:||||||.:.:||.:||:..||||||||||::||:||::||||||:|||
Mouse   423 GDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKE 487

  Fly  1324 GMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVN 1388
            .|..|..|.||||||:::|||::....|.::||||..|||::|||.|:.||.|:||:|:|.||:.
Mouse   488 HMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIME 552

  Fly  1389 DEVRYPRFLSLEAIAVMRRLLRKNPERRLGSSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPT 1453
            ..|.||:.||.||:::.:.|:.|:|.:|||.......||::.||||.|.|:.|..|:::|||.|.
Mouse   553 HNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPK 617

  Fly  1454 INHL---------------EDVSNFDEEFTSEKAQLTPPKEPRHLTEEEQLLFQDFSY 1496
            :...               :...|||:.||..:..|||| :...:...:|..|:.|||
Mouse   618 VTFCTKMHWLQWASRPSCGKGAENFDKFFTRGQPVLTPP-DQLVIANIDQSDFEGFSY 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012
		HR1_PKN_2	243..309	CDD:212013
		HR1_PKN_3	340..414	CDD:212015
		C2	530..611	CDD:301316
		STKc_PKN	1174..1499	CDD:270741	156/339 (46%)
		S_TKc	1174..1433	CDD:214567	131/259 (51%)
Prkca	XP_036012317.1	C1_cPKC_rpt1	35..92	CDD:410383
		C1_cPKC_rpt2	102..155	CDD:410386
		C2_PKC_alpha_gamma	159..289	CDD:175992
		STKc_cPKC_alpha	328..684	CDD:270766	157/350 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839309
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.870