DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pkn and pkn-1

DIOPT Version :9

Sequence 1:NP_001097237.1 Gene:Pkn / 35950 FlyBaseID:FBgn0020621 Length:1501 Species:Drosophila melanogaster
Sequence 2:NP_001360642.1 Gene:pkn-1 / 181244 WormBaseID:WBGene00009793 Length:1137 Species:Caenorhabditis elegans


Alignment Length:1544 Identity:460/1544 - (29%)
Similarity:659/1544 - (42%) Gaps:509/1544 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 LVKRIRSMINPSSQRDREDTTSVSASEGFIARRKCHSLPRRSNRHSTARRSNSGLWNRLVTNVFG 68
            :||.:.|....|...    |||...|........|::.|..|......|.|...:  |.:.:.|.
 Worm    50 VVKPLGSNFGASGSA----TTSTPKSVISSLTSACNNSPVLSFTRGVLRASRKKI--RPLFSTFS 108

  Fly    69 PEDS---YDFDNEGDSGGAVFYTDSVNG-----------------------SNYEISAEGEYIKH 107
            ...:   |.|::...|..|.:..:|.||                       |.|..:|..|.:  
 Worm   109 TSSNTGYYRFESPSSSLNAYYPQESFNGPILKMITCTESPPRSLDVLKRSKSTYWETAPAEMV-- 171

  Fly   108 PVLYELSHKYGFTENLPESCMSIRLEEIKEAIRREIRKELKIKEGAEKLREVAKDRRSLSDVAVL 172
                ||:.||.||.|...|.....| |::..||:::.|:||||.|..:::.:..|||....:...
 Worm   172 ----ELADKYNFTINEGSSIQQEAL-ELRSVIRKDLTKKLKIKSGYSRIKLITSDRRQSEFLRYE 231

  Fly   173 VKKSKSKLAELKSELQELESQILLTSANTAVNSNGQESITACIDPNGGFLVSGAVGGLGGGNTAL 237
            :.....::|:|:.:||.||          ..||...:.....:|              ...:..:
 Worm   232 LSDLNEQIADLQEDLQALE----------MYNSGAFDEDVMYLD--------------NLEDCDV 272

  Fly   238 EGGAPATANDKVLASLEKQLQIEMKVKTGAENMIQSLGIGCDKKLLAEAHQMLADSKAKIEFLRL 302
            |.|.|:.     |..|:.:|:.|:|||.|.|..::  |.....|:..::..:|.||:|||..||:
 Worm   273 ENGPPSK-----LVILQLELEKELKVKRGLEQFLR--GAPDKSKVHGDSQSLLDDSRAKIAMLRM 330

  Fly   303 RIIKVKQNREQADRLKASRQMIDEHGQTIGGNNSSQPQSLETTLEERIEELRHRLRIEAAVVDGA 367
            :|.::.|.....:                     .:|   :|.:|..|::|..|...|..::||:
 Worm   331 QIERLSQEAPAVE---------------------GEP---KTKVELAIDDLIIRFHKEKLIMDGS 371

  Fly   368 KNVIRTLQTANRAPDKKALQEAHGRLSESSRKLDLLRYSLDLRRQELPADSPAAQQLKTELQIVQ 432
            :|:||.|: :.|.||.||:.||......:|.|.||::.:|......||.:....:.|..|   :.
 Worm   372 RNMIRILR-SKRKPDSKAVDEAMNSYVIASEKADLIKLALLKYASSLPLEHDHRKYLIGE---IN 432

  Fly   433 LSTSPAPVTYTSLQSGQAGILGGKPYQSVSSLGRCA------SVTGKLEVRLLGCQDLLEDVPGR 491
            ....|.|.:.:..::..:...||   ...|:..||:      .::|.|||.:.||..:|.:|..|
 Worm   433 SGLIPKPPSLSQDRNSPSSEDGG---NGTSTSRRCSFMPYSLQISGCLEVTINGCAGILSEVFER 494

  Fly   492 SRRDKDNNSSPGDLRSFVKGVTSRSSSKSYSVKDETSIEIMAVIKLDNITVGQTSWKQCSQQAWD 556
            ..| ||....||.:.  |.|:.:....|..:....:|.|:..|:::||..:|.|..::...:.||
 Worm   495 KIR-KDVPGVPGFIS--VYGMDASGKKKKSARGPNSSEEVFCVLRIDNRFIGATELRKIVDRNWD 556

  Fly   557 QRFSIDLDRSRELEIGVYWRDWRSLCAVKVLRLEEFID-DVRHGMALQLEPQGLLFAEVKFLNPM 620
            |:|.:||||||||:|.:::.|.||:|....::|...|: ..:.|:.:.:||||.:|.:.|::||:
 Worm   557 QKFDVDLDRSRELQIELFYHDDRSMCGFAAVKLSNLIETSSKVGIIVPVEPQGNIFVQFKYMNPV 621

  Fly   621 ISQKPKLRRQRMIFNRQQAKNISRAKQMNINVATWGRLLKRNAPNHVHMGSAGSGSSLTGSSPMV 685
            :|:||||.|||.:|..:::.:.:|.|   :.|..:.||:|..                       
 Worm   622 VSRKPKLERQRRLFRVKESNDGARQK---LGVFAFSRLIKNR----------------------- 660

  Fly   686 VGGSRDSESPISRTPSSDALVEPEPYTPGEQAQNLEFDPDAGINEHVETPGEYPDPAASGLSGMR 750
                                                              |..|....:..:|..
 Worm   661 --------------------------------------------------GNEPSEKFAAFTGFT 675

  Fly   751 PLSMHMQGISVLPPESPPVATGAAGRPNTLSLQMPGASKGQVIQGGRTAAPTTAPPPPPVLKATS 815
            |:                        |::.|...||.|         ::.|:|:           
 Worm   676 PM------------------------PSSSSQHQPGTS---------SSGPSTS----------- 696

  Fly   816 TTPILDQELQDALHEFDFLSDLDSRPTTLRRLLKEQKMALDAGALENLLLQQQQTEQQALQQRQR 880
                               |.:.|.||                                      
 Worm   697 -------------------SSIASTPT-------------------------------------- 704

  Fly   881 QEQLRLQQFQEAQRQAILDLCVKQREPAEQTSPTLANQTPTFPPLASNQIMPSLNARPCQSQSPN 945
                                        ..||.:|.::       .||. :||.|.|.       
 Worm   705 ----------------------------PSTSNSLFDK-------VSNH-LPSFNPRK------- 726

  Fly   946 HNEFQLQPQPPHPAQKPTNPEPPSAVEQQLHRPVLILPPVVLLGGREEDRSVPPSPLVEYPEDDD 1010
                                                                             
 Worm   727 ----------------------------------------------------------------- 726

  Fly  1011 EYLYRGSNENLGTRLHSSHSSSAGDRFCVEVIPQLGKLYVGSSQQQYAQQSSPIIQEPATPTIYG 1075
                                                     |::::.|::               
 Worm   727 -----------------------------------------SAKKREARE--------------- 735

  Fly  1076 NSAAAGAPQFPQPAQRQEKQPPQQQPIYANQYELNVAKAAAAASVYSPSSSTTSNSNQQQQQQRR 1140
              |||.||                           :..|.||.::.:||   ||||.|...|:|.
 Worm   736 --AAAVAP---------------------------MTAAVAAVNLNAPS---TSNSMQPSTQERN 768

  Fly  1141 NVARGLQYRESGGLETGRAG--KQPP-------------NAGMLSMDNFRLLSVLGRGHFGKVIL 1190
            .|.        ....|.|:|  :.||             :...|:::.|||:|||||||||||||
 Worm   769 LVV--------DEFPTDRSGPSQAPPVPAVRHIDFFASSDGAPLTVEQFRLISVLGRGHFGKVIL 825

  Fly  1191 SQLRSNNQYYAIKALKKGDIIARDEVESLLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVME 1255
            ||....:.|||:|.||||||:.|||||||:.|||||||::..||||||||..||||.:||.|.||
 Worm   826 SQHNPTSNYYALKVLKKGDILGRDEVESLMVEKRIFEVSSRARHPFLVNLNGCFQTNEHVFFCME 890

  Fly  1256 YAAGGDLMMHIHTDVFLEPRAVFYAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGL 1320
            |:.|||||.|||.|||.|.|..||||||||||.:||::.|||||:||||||||.|||||||||||
 Worm   891 YSMGGDLMRHIHDDVFDEVRGCFYAACVVLGLDFLHKHNIIYRDIKLDNLLLDREGYVKIADFGL 955

  Fly  1321 CKEGMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDS 1385
            |||.||..|:|.||||||||||||||:::|||||:||||||||||||||||.||.||||||:|||
 Worm   956 CKENMGPFDKTSTFCGTPEFLAPEVLSDSSYTRAIDWWGLGVLIFEMLVGEPPFSGDDEEEIFDS 1020

  Fly  1386 IVNDEVRYPRFLSLEAIAVMRRLLRKNPERRLGSSERDAEDVKKQAFFRSI--VWDDLLLRKVKP 1448
            |::::|||||:||:|:||:|||||||.||:|||..||||||:|.|.|||.|  .||.||.|:::|
 Worm  1021 IISEDVRYPRYLSVESIAIMRRLLRKVPEKRLGYGERDAEDIKIQRFFRHISWEWDKLLNREIRP 1085

  Fly  1449 PFVPTINHLEDVSNFDEEFTSEKAQLTPPKEPRHLTEEEQLLFQDFSYT 1497
            ||.|.|.:.|||||||.|||.|||:.:.....|.:||.:|.||.:|.::
 Worm  1086 PFQPQIRNPEDVSNFDLEFTQEKARFSAASSTRPITEADQRLFNNFDFS 1134

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PknNP_001097237.1 HR1_PKN_1 131..194 CDD:212012 19/62 (31%)
HR1_PKN_2 243..309 CDD:212013 20/65 (31%)
HR1_PKN_3 340..414 CDD:212015 24/73 (33%)
C2 530..611 CDD:301316 30/81 (37%)
STKc_PKN 1174..1499 CDD:270741 227/326 (70%)
S_TKc 1174..1433 CDD:214567 193/258 (75%)
pkn-1NP_001360642.1 HR1_PKN_1 188..253 CDD:212012 19/75 (25%)
HR1_PKN_2 273..339 CDD:212013 24/72 (33%)
HR1 344..410 CDD:381797 24/69 (35%)
C2 527..>589 CDD:387358 24/61 (39%)
STKc_PKN 809..1134 CDD:270741 227/324 (70%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160159746
Domainoid 1 1.000 383 1.000 Domainoid score I431
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H2054
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49182
OrthoDB 1 1.010 - - D241576at33208
OrthoFinder 1 1.000 - - FOG0001458
OrthoInspector 1 1.000 - - oto17614
orthoMCL 1 0.900 - - OOG6_103771
Panther 1 1.100 - - LDO PTHR24356
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R891
SonicParanoid 1 1.000 - - X914
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1211.890

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