DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkn and pkc-1

DIOPT Version :9

Sequence 1:	NP_001097237.1	Gene:	Pkn / 35950	FlyBaseID:	FBgn0020621	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	NP_001256396.1	Gene:	pkc-1 / 179649	WormBaseID:	WBGene00004032	Length:	763	Species:	Caenorhabditis elegans

Alignment Length:	377	Identity:	172/377 - (45%)
Similarity:	239/377 - (63%)	Gaps:	21/377 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly  1125 SSTTSNSNQQQQQQRRNVARGLQYRESGGLETGRAGKQPPNAGMLSMDNFRLLSVLGRGHFGKVI 1189
            ||.:.||...||         :...:||...:..|.|.|  .|.||:.:|..:.|||:|.||||:
Worm   396 SSNSENSGYLQQ---------ISEDDSGTTSSRSASKVP--GGTLSIHDFTFMKVLGKGSFGKVM 449

  Fly  1190 LSQLRSNNQYYAIKALKKGDIIARDEVESLLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVM 1254
            |::.:..::.||||.|||..|:..|:||..:.||||..:  |.:||||..|:|.|||...:.|||
Worm   450 LAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSL--AAKHPFLTALHSSFQTSDRLFFVM 512

  Fly  1255 EYAAGGDLMMHI-HTDVFLEPRAVFYAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADF 1318
            ||..|||||..| ....|.|.||.||||.|...||:||.|.:|||||||||:|||.||:.::|||
Worm   513 EYVNGGDLMFQIQRARKFDESRARFYAAEVTCALQFLHRNDVIYRDLKLDNILLDAEGHCRLADF 577

  Fly  1319 GLCKEGMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVF 1383
            |:||||:...:.|.||||||:::|||:|.|..|..:||||.||||::||:.|:.||..|:|:::|
Worm   578 GMCKEGINKDNLTSTFCGTPDYIAPEILQEMEYGVSVDWWALGVLMYEMMAGQPPFEADNEDDLF 642

  Fly  1384 DSIVNDEVRYPRFLSLEAIAVMRRLLRKNPERRLGS--SERDAEDVKKQAFFRSIVWDDLLLRKV 1446
            ::|:||:|.||.:||.||:.:::..:.||..:|||.  |:...:.::...|||.|.||.|..|:|
Worm   643 EAILNDDVLYPVWLSKEAVNILKAFMTKNAGKRLGCVVSQGGEDAIRAHPFFREIDWDALESRQV 707

  Fly  1447 KPPFVPTINHLEDVSNFDEEFTSEKAQLTP--PKEPRHLTEEEQLLFQDFSY 1496
            ||||.|.|....|.:|||.:||.|:..|||  |...|.:.::|   |:.||:
Worm   708 KPPFKPKIKSKRDANNFDSDFTKEEPVLTPSDPAVVRAINQDE---FRGFSF 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012
		HR1_PKN_2	243..309	CDD:212013
		HR1_PKN_3	340..414	CDD:212015
		C2	530..611	CDD:301316
		STKc_PKN	1174..1499	CDD:270741	158/328 (48%)
		S_TKc	1174..1433	CDD:214567	127/261 (49%)
pkc-1	NP_001256396.1	C2_PKC_epsilon	59..188	CDD:175981
		C1_1	227..279	CDD:278556
		C1_1	305..357	CDD:278556
		S_TKc	434..694	CDD:214567	127/261 (49%)
		STKc_nPKC_epsilon	438..758	CDD:270743	157/324 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940