DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkn and tpa-1

DIOPT Version :9

Sequence 1:	NP_001097237.1	Gene:	Pkn / 35950	FlyBaseID:	FBgn0020621	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	NP_001379590.1	Gene:	tpa-1 / 176825	WormBaseID:	WBGene00006599	Length:	704	Species:	Caenorhabditis elegans

Alignment Length:	412	Identity:	166/412 - (40%)
Similarity:	239/412 - (58%)	Gaps:	22/412 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly  1105 NQYELN-----VAKAAAAASVYSPS------SSTTSNSNQQQQQQRRNVARGLQYRESGGLETGR 1158
            ||.:|:     :.:...|.:...|:      :..||.:|.....:.:|:.:..||......||..
Worm   290 NQKQLSEMYHEIKRGTHATASCPPNIANLHLNGETSKNNGSLPNKLKNLFKSHQYSVEEQKETDE 354

  Fly  1159 ------AGKQPPNAGMLSMDNFRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVE 1217
                  .|...| ....::.:|.||.|||:|.||||:|.:|:..|::||:|.|||..|:..|:.|
Worm   355 YMDNIWGGGDGP-VKKFALPHFNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDTE 418

  Fly  1218 SLLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHI-HTDVFLEPRAVFYAA 1281
            ....|:|:..:|:  :.|||..|:..|||.:::.|||||..|||||.|| ....|.|.|..|||.
Worm   419 CTYIERRVLILAS--QCPFLCQLFCSFQTNEYLFFVMEYLNGGDLMHHIQQIKKFDEARTRFYAC 481

  Fly  1282 CVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMG-FGDRTGTFCGTPEFLAPEV 1345
            .:|:.||:||.|.||||||||||:|||.:|::|:||||:.|..|. ......||||||::::||:
Worm   482 EIVVALQFLHTNNIIYRDLKLDNVLLDCDGHIKLADFGMAKTEMNRENGMASTFCGTPDYISPEI 546

  Fly  1346 LTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRRLLR 1410
            :....|..|||:|..|||::|||||:|||.|:.|:|:||||:|:...:|:.:|.||...:..|..
Worm   547 IKGQLYNEAVDFWSFGVLMYEMLVGQSPFHGEGEDELFDSILNERPYFPKTISKEAAKCLSALFD 611

  Fly  1411 KNPERRLGSSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLT 1475
            :||..|||..|.....:::..|||.:.|.....|:|.|||.|.|....|.||||::||:|||.||
Worm   612 RNPNTRLGMPECPDGPIRQHCFFRGVDWKRFENRQVPPPFKPNIKSNSDASNFDDDFTNEKAALT 676

  Fly  1476 PPKEPRHLTEEEQLLFQDFSYT 1497
            |..:...|...:...|.:||||
Worm   677 PVHDKNLLASIDPEAFLNFSYT 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012
		HR1_PKN_2	243..309	CDD:212013
		HR1_PKN_3	340..414	CDD:212015
		C2	530..611	CDD:301316
		STKc_PKN	1174..1499	CDD:270741	151/326 (46%)
		S_TKc	1174..1433	CDD:214567	121/260 (47%)
tpa-1	NP_001379590.1	C1_nPKC_theta-like_rpt1	159..219	CDD:410384
		C1_nPKC_theta-like_rpt2	238..287	CDD:410387
		STKc_nPKC_theta_like	379..700	CDD:270744	148/322 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940