DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkn and prkch

DIOPT Version :9

Sequence 1:	NP_001097237.1	Gene:	Pkn / 35950	FlyBaseID:	FBgn0020621	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	XP_002939521.2	Gene:	prkch / 100151731	XenbaseID:	XB-GENE-486685	Length:	691	Species:	Xenopus tropicalis

Alignment Length:	416	Identity:	176/416 - (42%)
Similarity:	246/416 - (59%)	Gaps:	52/416 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly  1108 ELNVAKAAAAASV--------------------YSPSSSTTSNSNQQQQQQRRNVARGLQYRESG 1152
            |.|||......||                    :|.|.|..|:||..::....|.:.  ||:
Frog   287 EANVAHNCGVNSVDLANALAGMGLHPGNIPFKQHSVSGSVDSDSNHLEEDSISNTSS--QYK--- 346

  Fly  1153 GLETGRAGKQPPNAGMLSMDNFRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVE 1217
                            ..:|:|..|.|||:|.||||:|::.:.::..||:|.|||..|:..|:||
Frog   347 ----------------FGIDDFTFLRVLGKGSFGKVMLAKSKESDSLYAVKVLKKDVILQDDDVE 395

  Fly  1218 SLLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIH-TDVFLEPRAVFYAA 1281
            ..::||||..:  |..||||..|:.||||...:.||||:..|||||.||. :..|.|.||.||:|
Frog   396 CTMTEKRILSL--ACNHPFLTQLFCCFQTLDRLFFVMEFVNGGDLMFHIQKSRRFDEARACFYSA 458

  Fly  1282 CVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPEFLAPEVL 1346
            .:...|.:||:..:|||||||||:|||.||:.|:||||:||||:..|..|.||||||:::|||:|
Frog   459 EITSALMFLHDKGVIYRDLKLDNVLLDHEGHCKLADFGMCKEGIREGCTTSTFCGTPDYIAPEIL 523

  Fly  1347 TETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRRLLRK 1411
            .|..|...||||.:|||::|||.|.:||..::|:::|::|:||||.||.:||.:|:.:::..::|
Frog   524 QEMQYGPLVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPGWLSQDAVEILQAFMKK 588

  Fly  1412 NPERRLGSSERDAED-VKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLT 1475
            .|.:||||.....|. :....||:.|.||:|..:.::|||.|.|...|||||||.||..|.|.||
Frog   589 KPAKRLGSLSLGGEKAILWHPFFKDINWDELNKKTIEPPFRPRIKAREDVSNFDPEFIKEDAVLT 653

  Fly  1476 PPKE---PRHLTEEEQLLFQDFSYTA 1498
            |..|   |  |..:|:  |::|||||
Frog   654 PIDESLLP--LINQEE--FRNFSYTA 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012
		HR1_PKN_2	243..309	CDD:212013
		HR1_PKN_3	340..414	CDD:212015
		C2	530..611	CDD:301316
		STKc_PKN	1174..1499	CDD:270741	160/330 (48%)
		S_TKc	1174..1433	CDD:214567	125/260 (48%)
prkch	XP_002939521.2	C2_PKC_epsilon	7..139	CDD:175981
		C1_1	171..221	CDD:365894
		C1_1	245..295	CDD:365894	4/7 (57%)
		STKc_nPKC_eta	356..678	CDD:270742	158/326 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000