DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkn and prkcdb

DIOPT Version :9

Sequence 1:	NP_001097237.1	Gene:	Pkn / 35950	FlyBaseID:	FBgn0020621	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	NP_001352166.1	Gene:	prkcdb / 100150844	ZFINID:	ZDB-GENE-111129-1	Length:	685	Species:	Danio rerio

Alignment Length:	408	Identity:	176/408 - (43%)
Similarity:	252/408 - (61%)	Gaps:	26/408 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly  1104 ANQYELNVAKAAAAASVYSPSSST-----TSNSNQQQQQQRRNV-----ARGLQYRESGGLETGR 1158
            ||...:|....|.|.:..|..|||     |.:.....|...:||     |.|.||.:...:....
Zfish   278 ANLCGINQKLLAEALNQVSLKSSTKRPDPTLSEIGIYQAIDKNVPADPSAEGSQYGKFWDITPAV 342

  Fly  1159 AGKQPPNAGMLSMDNFRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVESLLSEK 1223
            ......:...:|:::|....|||:|.||||:|::|:...||:|||||||..::..|:||..:.||
Zfish   343 PASTIVSTVRVSLNDFVFQKVLGKGSFGKVMLAELKGKGQYFAIKALKKDVVLMDDDVECTMVEK 407

  Fly  1224 RIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIHT----DVFLEPRAVFYAACVV 1284
            |:  :|.|..:|||.:||..||:::|:.|||||..|||||.||..    |::   ||.||||.::
Zfish   408 RV--LALAWENPFLTHLYCTFQSKEHLFFVMEYLNGGDLMFHIQDKGRFDLY---RATFYAAEII 467

  Fly  1285 LGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPEFLAPEVLTET 1349
            .||||||...|:||||||||::||.:|::||||||:|||.|...:|..||||||:::|||:|...
Zfish   468 CGLQYLHSKGIVYRDLKLDNVMLDKDGHIKIADFGMCKENMIGENRATTFCGTPDYIAPEILLGQ 532

  Fly  1350 SYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRRLLRKNPE 1414
            .|:.:||||..|||::|||:|:|||.||||:|:||||..|...|||:::.||..::.:|..::|.
Zfish   533 KYSFSVDWWSFGVLLYEMLIGQSPFQGDDEDELFDSIRMDVPHYPRWITKEAKDLLEKLFERDPT 597

  Fly  1415 RRLGSSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLTPPKE 1479
            ||||.    ..:::..|||::|.|..|..|:|.|||.|.:....|.||||.||.|||.:|:  :.
Zfish   598 RRLGV----VGNIRGHAFFKTINWPALEKREVSPPFKPKVKSSSDCSNFDREFLSEKPRLS--QS 656

  Fly  1480 PRHLTEE-EQLLFQDFSY 1496
            .::|.:. :|..|..||:
Zfish   657 DKNLIDSMDQTAFAGFSF 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012
		HR1_PKN_2	243..309	CDD:212013
		HR1_PKN_3	340..414	CDD:212015
		C2	530..611	CDD:301316
		STKc_PKN	1174..1499	CDD:270741	158/328 (48%)
		S_TKc	1174..1433	CDD:214567	131/262 (50%)
prkcdb	NP_001352166.1	C1_1	160..209	CDD:278556
		C1_1	232..284	CDD:278556	2/5 (40%)
		PKc_like	362..677	CDD:328722	157/324 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0694
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840