DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkn and prkcg

DIOPT Version :9

Sequence 1:	NP_001097237.1	Gene:	Pkn / 35950	FlyBaseID:	FBgn0020621	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	XP_001921715.1	Gene:	prkcg / 100003514	ZFINID:	ZDB-GENE-090206-1	Length:	695	Species:	Danio rerio

Alignment Length:	345	Identity:	164/345 - (47%)
Similarity:	225/345 - (65%)	Gaps:	15/345 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly  1154 LETGRAGKQPPNAGMLSMDNFRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDE-VE 1217
            |.||:        |.:.:.:|..|.|||:|.||||:|::.:.:.:.:|||.||| |::.:|| .|
Zfish   351 LHTGK--------GHIGLHDFNFLMVLGKGSFGKVLLAEEKGSERLFAIKMLKK-DVLFQDEDTE 406

  Fly  1218 SLLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIH-TDVFLEPRAVFYAA 1281
            |.:.|:|:..::.  |..||.:||..||||..:.:||||..|||||.||. ...|.||.|.||||
Zfish   407 SAMVERRVLALSG--RPHFLTSLYCAFQTEDRLYYVMEYVNGGDLMFHIQIVGKFKEPHAAFYAA 469

  Fly  1282 CVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPEFLAPEVL 1346
            .:.:||.:||...||||||||||:|||:||::||||||:|:|||..||.|.||||||:::|||::
Zfish   470 EIAVGLFFLHNKGIIYRDLKLDNVLLDSEGHIKIADFGMCREGMMEGDTTRTFCGTPDYIAPEIV 534

  Fly  1347 TETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRRLLRK 1411
            ....|.:|||||..|||::|||.|:.||.|.||||:|.||:...|.||:.||.||:|:.:.||.|
Zfish   535 AYQPYGKAVDWWSYGVLLYEMLAGQPPFDGIDEEELFQSIMEQSVSYPKSLSREAVAICKGLLTK 599

  Fly  1412 NPERRLGSSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLTP 1476
            ||.:|||..|....::::..|||.|.||.|...:::|||.|.....:. .|||:.|||..:.||
Zfish   600 NPAKRLGGGEDAERELREHPFFRWIDWDRLERLEIQPPFKPRSGGKKG-ENFDKFFTSTSSALT- 662

  Fly  1477 PKEPRHLTEEEQLLFQDFSY 1496
            |.:|..|....|..||||::
Zfish   663 PSDPDVLAAINQEEFQDFTF 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012
		HR1_PKN_2	243..309	CDD:212013
		HR1_PKN_3	340..414	CDD:212015
		C2	530..611	CDD:301316
		STKc_PKN	1174..1499	CDD:270741	160/325 (49%)
		S_TKc	1174..1433	CDD:214567	133/260 (51%)
prkcg	XP_001921715.1	C1_1	56..108	CDD:278556
		C1_1	121..173	CDD:278556
		C2_PKC_alpha_gamma	178..308	CDD:175992
		S_TKc	363..621	CDD:214567	133/260 (51%)
		STKc_cPKC	366..684	CDD:270739	159/322 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583340
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840