DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hig and SVEP1

DIOPT Version :9

Sequence 1:	NP_724773.1	Gene:	hig / 35949	FlyBaseID:	FBgn0010114	Length:	958	Species:	Drosophila melanogaster
Sequence 2:	NP_699197.3	Gene:	SVEP1 / 79987	HGNCID:	15985	Length:	3571	Species:	Homo sapiens

Alignment Length:	634	Identity:	161/634 - (25%)
Similarity:	238/634 - (37%)	Gaps:	153/634 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   435 DDPEFDEEEEEDEEVDIL------------QQFTEVSEIRFPGEIGPMGDRRLCKIRCVKGKWVG 487
            ||..:||:|.....||..            .::|...||.:....|.:.:....::....|.|.|
Human  2817 DDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSG 2881

  Fly   488 ------PL-CATNEEDDNG-----------NVKFQPLYKSCHVNRI----PSHLLLSYRNISV-T 529
                  |: |||..:..||           .|.|.     ||...|    |.....|..|... .
Human  2882 ATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFH-----CHEGYILHGAPKLTCQSDGNWDAEI 2941

  Fly   530 PI--PPNRGWRKTRLSKSTLLSNTEINVGWDLPHGHSLQARCQELGIYKLLGESRVLC-SNGLWA 591
            |:  |.|.|..:.       |::...| |:...||..:|.:|  ...|||.|.|...| |||.|:
Human  2942 PLCKPVNCGPPED-------LAHGFPN-GFSFIHGGHIQYQC--FPGYKLHGNSSRRCLSNGSWS 2996

  Fly   592 PRMPSCVP---TTVLTNYSE------DSAPSIRIKIFNGSHSFEPSGVMAVP-----------PH 636
            ...|||:|   :|.:..|..      |...:.||:.|.|   |:..|:..:.           ||
Human  2997 GSSPSCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKG---FKLLGLSEITCEADGQWSSGFPH 3058

  Fly   637 STVLMDC---------MYPRVRGTPEWSWTSWYMQYS--TG----------------WS---PAQ 671
                  |         |.|....:...||....:.||  :|                ||   |..
Human  3059 ------CEHTSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVC 3117

  Fly   672 E----------------------EKAVRYRLSIKNIENNDSGTFTCTSP-RGLTNSIAVVVATST 713
            |                      |..|:.|.......:.|:.||||... |.....|:  .:...
Human  3118 EPLSCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERIS--CSPKK 3180

  Fly   714 CPQLTEPLAPLKLRLEGNKLGQRAHYECPEGFRLDGAWNATCLASGNWSSP--TPTCHAIQCPRL 776
            || |.|.:..:.:..:...:.::....|.||:..:|...:.|...|.|..|  ..:|..:.|.:.
Human  3181 CP-LPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKP 3244

  Fly   777 ELDDPHLSLIELNTSAWGRAVFKCQWGFKLTGPAQLDCEPSGVWSGPVPRCKVIQCVMPVAPLNG 841
            |..: |..::....:.....:::|:.|::|.|..:..|:.:..|||.|..||..:|..|:..|||
Human  3245 ESPE-HGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNG 3308

  Fly   842 RIGGTSLSQRRLTVGALVTFSCNDGHSLVGESSIICTENGQWSHSPPFCK-SQCPYP-GDPPNGL 904
            :   ..:..|  |.|..|.:|||.|:||.|.|...|||||.|||..|.|| :.||.| ..|.|.|
Human  3309 K---ADIENR--TTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENAL 3368

  Fly   905 IAPLKFNYDAGDYLSVQCRPGFVQSYEGPPERPKCQPDGRWSGPMPKCK 953
            ::..:|..|..  :|::||.||:....|   ...|.||..|:....||:
Human  3369 LSEKEFYVDQN--VSIKCREGFLLQGHG---IITCNPDETWTQTSAKCE 3412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hig	NP_724773.1	PHA02927	705..952	CDD:222943	74/250 (30%)
		CCP	714..768	CDD:153056	12/55 (22%)
		CCP	<795..828	CDD:153056	9/32 (28%)
		CCP	832..891	CDD:153056	26/58 (45%)
		Sushi	894..952	CDD:278512	18/58 (31%)
SVEP1	NP_699197.3	VWA	84..258	CDD:278519
		GCC2_GCC3	310..360	CDD:285001
		CCP	378..434	CDD:153056
		CCP	438..494	CDD:153056
		DUF5011	560..642	CDD:295940
		DUF5011	643..722	CDD:295940
		O-glycosylated at one site	887..894
		GCC2_GCC3	1005..1052	CDD:285001
		GCC2_GCC3	1059..1106	CDD:285001
		GCC2_GCC3	1113..1160	CDD:285001
		EGF	1197..1225	CDD:278437
		EGF_CA	1231..1267	CDD:238011
		EGF_CA	1269..1305	CDD:238011
		EGF_CA	1308..1342	CDD:238011
		EGF_CA	1345..1381	CDD:238011
		EGF_CA	1383..1419	CDD:238011
		LamG	1424..1622	CDD:304605
		Sushi	1628..1685	CDD:278512
		CCP	1690..1743	CDD:153056
		EGF_CA	1745..1783	CDD:214542
		PHA02927	1789..2017	CDD:222943
		CCP	1789..1843	CDD:153056
		CCP	1847..1901	CDD:153056
		CCP	1905..1958	CDD:153056
		CCP	1963..2016	CDD:153056
		Sushi	2021..2078	CDD:278512
		CCP	2083..2136	CDD:153056
		PHA02927	2137..2376	CDD:222943
		CCP	2146..2199	CDD:153056
		CCP	2204..2260	CDD:153056
		CCP	2264..2318	CDD:153056
		CCP	2323..2377	CDD:153056
		CCP	2381..2436	CDD:153056
		CCP	2440..2494	CDD:153056
		PHA02927	2498..2770	CDD:222943
		CCP	2498..2551	CDD:214478
		CCP	2556..2608	CDD:153056
		CCP	<2670..2713	CDD:153056
		CCP	2717..2771	CDD:153056
		PHA02927	2770..3003	CDD:222943	51/200 (26%)
		CCP	2775..2828	CDD:214478	5/10 (50%)
		CCP	2833..2887	CDD:153056	7/53 (13%)
		Cell attachment site. /evidence=ECO:0000255	2845..2847		0/1 (0%)
		CCP	2891..2945	CDD:153056	14/58 (24%)
		CCP	2949..3002	CDD:214478	19/62 (31%)
		Sushi	3007..3059	CDD:278512	11/60 (18%)
		CCP	3064..3118	CDD:153056	10/53 (19%)
		Sushi	3181..3231	CDD:278512	11/50 (22%)
		CCP	3241..3295	CDD:153056	12/54 (22%)
		CCP	3299..3353	CDD:153056	26/58 (45%)
		CCP	3357..3412	CDD:153056	19/59 (32%)
		CCP	3416..3469	CDD:153056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I11196
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D31246at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920