Protein Alignment hig and Svep1

DIOPT Version :10

• Sequence 1: NP_724773.1
• Gene: hig / 35949
• FlyBaseID: FBgn0010114
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_001406613.1
• Gene: Svep1 / 685899
• RGDID: 1588987
• Length: 3568
• Species: Rattus norvegicus
• Alignment Length: 789
• Identity: 173/789 - (21%)
• Similarity: 271/789 - (34%)
• Gaps: 212/789 - (26%)

  Fly   294 NGQTPKEDELELD---HPETAAAHHRRRGDSHAAELDQRD-------------RSPRWRRRRSTE 342
            ||..|....:|.|   .||....|..:.....||:...:.             ::.:|.
  Rat  2704 NGTAPSCISIECDLPVAPENGFLHFTQTTMGSAAQYSCKPGHVLEGSHLRLCLQNKQWS------ 2762

  Fly   343 FKGDLGQLPPESGIG-PEPEPLADQDLKDLQQYGNQSSSARVALLWQRVKRKSGKTTGALSRPKG 406
                 |.:|....|. .||.||.:..:|     ||..|                 ..|.|.....
  Rat  2763 -----GTVPRCEVISCSEPNPLGNGSIK-----GNDYS-----------------YLGVLHYECD 2800

  Fly   407 GG---DSSSKTTSRKDKGIYDEEAGYTPIHPDDPEFDEEEEEDEEVDILQQFTEVSEIRFPGEIG 468
            .|   :.:.|.|.:::|.....|....|:....|......:...|     ::|...||.:....|
  Rat  2801 SGYVLNGTEKRTCQENKQWDGHEPVCLPVDCGSPPVPTNGQVTGE-----EYTFQKEIAYSCGEG 2860

  Fly   469 PMGDRRLCKIRCVKGKWVG--PLC----------ATNEEDDNGNVKFQPLYKSCHVNRIPSHLLL 521
            .:.:....::....|.|.|  |.|          ..|...|..:..|:        ..:..|.|.
  Rat  2861 FILEGARSRVCLTNGSWSGTTPSCVPVRCPAPPQVANGVTDGLDYGFK--------KEVTFHCLE 2917

  Fly   522 SYRNISVTPIPPNRGWRKTRLSKSTLLSN----TEINV------------------GWDLPHGHS 564
            .| .:..||             |.|..||    .|:.:                  |:...||..
  Rat  2918 GY-VLQGTP-------------KLTCQSNGTWDAEVPICKPATCGPPADLPQGFPNGFSFFHGGH 2968

  Fly   565 LQARCQELGIYKLLGE-SRVLCSNGLWAPRMPSCVPTTVLTNYSEDS---------APSIRIKIF 619
            :|.:|  ...|||.|. ||....:|.|:...|||:|.|..|...:..         ..:::|:.|
  Rat  2969 IQYQC--FTGYKLHGNPSRRCLPDGSWSGSTPSCLPCTCSTPIIQQGTVNATDLGCGKTVQIECF 3031

  Fly   620 NG-----------------------SHS------FEPSGVM--AVPPHSTVLMDCMYPR--VRGT 651
            .|                       .|:      ..|:|::  ..|....|:.....|.  ::|:
  Rat  3032 KGFKLLGLPEITCDANGQWSDFPLCEHADCGPLPTVPNGIVIKGSPSEDNVVTYSCRPGYIIQGS 3096

  Fly   652 PEWSWTS---WYMQY------------------STGWSPAQEEKAVRYRLSIKNIENNDSGTFTC 695
            .:...|.   |...|                  :||.:...|.| |:.|.....:.:.|:.||||
  Rat  3097 SDLICTEKGIWSEPYPTCEPVSCGPPPTVANAVATGEAHTYESK-VKLRCLEGYVVDTDTDTFTC 3160

  Fly   696 TS-----PRGLTNSIAVVVATSTCPQLTEPLAPLKLRLEGN--KLGQRAHYECPEGFRLDGAWNA 753
            ..     |..:..|      ..|||   .|....::|:.|:  ::.::....|.|||..|||..:
  Rat  3161 QQDGRWFPERINCS------PKTCP---VPSNRTRIRVHGDDFQVNRQVSVSCTEGFTYDGADRS 3216

  Fly   754 TCLASGNWSSP--TPTCHAIQCPRLELDDPHLSLIELNTSAWGRAVFKCQWGFKLTGPAQLDCEP 816
            ||...|.|..|  ..:|..:.|.:.|..: |..::....|.....|::|..|::|.|..:..|:.
  Rat  3217 TCQPDGTWEPPLSEESCIPVVCGQPESPE-HGFVVGSEYSFGSTVVYQCDPGYELEGNRERVCQE 3280

  Fly   817 SGVWSGPVPRCKVIQCVMPVAPLNGRIGGTSLSQRRLTVGALVTFSCNDGHSLVGESSIICTENG 881
            :..|||.|..|:..:|..|....||:     ......|.|..:.|||:.|::|.|.....||.||
  Rat  3281 NRQWSGRVAVCRESRCEAPAEFPNGK-----AVLENTTSGPSLLFSCHRGYTLEGPPEAHCTANG 3340

  Fly   882 QWSHSPPFCK-SQCPYP-GDPPNGLIAPLKFNYDAGDYLSVQCRPGFVQSYEGPPERPKCQPDGR 944
            .|||..|.|| :.||.| ..|.|.|::..:|..:..  :|::||.||:....|   ...|.||..
  Rat  3341 TWSHLAPLCKPNPCPVPFVIPENALLSEREFYVNQN--VSIKCREGFLLKGNG---IITCNPDET 3400

  Fly   945 WSGPMPKCK 953
            |:....:|:
  Rat  3401 WTQTNARCE 3409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hig	NP_724773.1	Ig_3	612..696	CDD:464046	23/137 (17%)
		PHA02927	705..952	CDD:222943	73/252 (29%)
Svep1	NP_001406613.1	Important for the interaction with integrin ITGA9:ITGB1. /evidence=ECO:0000250|UniProtKB:A2AVA0	2638..2645