DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hig and Svep1

DIOPT Version :9

Sequence 1:	NP_724773.1	Gene:	hig / 35949	FlyBaseID:	FBgn0010114	Length:	958	Species:	Drosophila melanogaster
Sequence 2:	XP_038966967.1	Gene:	Svep1 / 685899	RGDID:	1588987	Length:	3705	Species:	Rattus norvegicus

Alignment Length:	789	Identity:	173/789 - (21%)
Similarity:	271/789 - (34%)	Gaps:	212/789 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 NGQTPKEDELELD---HPETAAAHHRRRGDSHAAELDQRD-------------RSPRWRRRRSTE 342
            ||..|....:|.|   .||....|..:.....||:...:.             ::.:|.
  Rat  2841 NGTAPSCISIECDLPVAPENGFLHFTQTTMGSAAQYSCKPGHVLEGSHLRLCLQNKQWS------ 2899

  Fly   343 FKGDLGQLPPESGIG-PEPEPLADQDLKDLQQYGNQSSSARVALLWQRVKRKSGKTTGALSRPKG 406
                 |.:|....|. .||.||.:..:|     ||..|                 ..|.|.....
  Rat  2900 -----GTVPRCEVISCSEPNPLGNGSIK-----GNDYS-----------------YLGVLHYECD 2937

  Fly   407 GG---DSSSKTTSRKDKGIYDEEAGYTPIHPDDPEFDEEEEEDEEVDILQQFTEVSEIRFPGEIG 468
            .|   :.:.|.|.:::|.....|....|:....|......:...|     ::|...||.:....|
  Rat  2938 SGYVLNGTEKRTCQENKQWDGHEPVCLPVDCGSPPVPTNGQVTGE-----EYTFQKEIAYSCGEG 2997

  Fly   469 PMGDRRLCKIRCVKGKWVG--PLC----------ATNEEDDNGNVKFQPLYKSCHVNRIPSHLLL 521
            .:.:....::....|.|.|  |.|          ..|...|..:..|:        ..:..|.|.
  Rat  2998 FILEGARSRVCLTNGSWSGTTPSCVPVRCPAPPQVANGVTDGLDYGFK--------KEVTFHCLE 3054

  Fly   522 SYRNISVTPIPPNRGWRKTRLSKSTLLSN----TEINV------------------GWDLPHGHS 564
            .| .:..||             |.|..||    .|:.:                  |:...||..
  Rat  3055 GY-VLQGTP-------------KLTCQSNGTWDAEVPICKPATCGPPADLPQGFPNGFSFFHGGH 3105

  Fly   565 LQARCQELGIYKLLGE-SRVLCSNGLWAPRMPSCVPTTVLTNYSEDS---------APSIRIKIF 619
            :|.:|  ...|||.|. ||....:|.|:...|||:|.|..|...:..         ..:::|:.|
  Rat  3106 IQYQC--FTGYKLHGNPSRRCLPDGSWSGSTPSCLPCTCSTPIIQQGTVNATDLGCGKTVQIECF 3168

  Fly   620 NG-----------------------SHS------FEPSGVM--AVPPHSTVLMDCMYPR--VRGT 651
            .|                       .|:      ..|:|::  ..|....|:.....|.  ::|:
  Rat  3169 KGFKLLGLPEITCDANGQWSDFPLCEHADCGPLPTVPNGIVIKGSPSEDNVVTYSCRPGYIIQGS 3233

  Fly   652 PEWSWTS---WYMQY------------------STGWSPAQEEKAVRYRLSIKNIENNDSGTFTC 695
            .:...|.   |...|                  :||.:...|.| |:.|.....:.:.|:.||||
  Rat  3234 SDLICTEKGIWSEPYPTCEPVSCGPPPTVANAVATGEAHTYESK-VKLRCLEGYVVDTDTDTFTC 3297

  Fly   696 TS-----PRGLTNSIAVVVATSTCPQLTEPLAPLKLRLEGN--KLGQRAHYECPEGFRLDGAWNA 753
            ..     |..:..|      ..|||   .|....::|:.|:  ::.::....|.|||..|||..:
  Rat  3298 QQDGRWFPERINCS------PKTCP---VPSNRTRIRVHGDDFQVNRQVSVSCTEGFTYDGADRS 3353

  Fly   754 TCLASGNWSSP--TPTCHAIQCPRLELDDPHLSLIELNTSAWGRAVFKCQWGFKLTGPAQLDCEP 816
            ||...|.|..|  ..:|..:.|.:.|..: |..::....|.....|::|..|::|.|..:..|:.
  Rat  3354 TCQPDGTWEPPLSEESCIPVVCGQPESPE-HGFVVGSEYSFGSTVVYQCDPGYELEGNRERVCQE 3417

  Fly   817 SGVWSGPVPRCKVIQCVMPVAPLNGRIGGTSLSQRRLTVGALVTFSCNDGHSLVGESSIICTENG 881
            :..|||.|..|:..:|..|....||:     ......|.|..:.|||:.|::|.|.....||.||
  Rat  3418 NRQWSGRVAVCRESRCEAPAEFPNGK-----AVLENTTSGPSLLFSCHRGYTLEGPPEAHCTANG 3477

  Fly   882 QWSHSPPFCK-SQCPYP-GDPPNGLIAPLKFNYDAGDYLSVQCRPGFVQSYEGPPERPKCQPDGR 944
            .|||..|.|| :.||.| ..|.|.|::..:|..:..  :|::||.||:....|   ...|.||..
  Rat  3478 TWSHLAPLCKPNPCPVPFVIPENALLSEREFYVNQN--VSIKCREGFLLKGNG---IITCNPDET 3537

  Fly   945 WSGPMPKCK 953
            |:....:|:
  Rat  3538 WTQTNARCE 3546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hig	NP_724773.1	PHA02927	705..952	CDD:222943	73/252 (29%)
		CCP	714..768	CDD:153056	17/57 (30%)
		CCP	<795..828	CDD:153056	10/32 (31%)
		CCP	832..891	CDD:153056	20/58 (34%)
		Sushi	894..952	CDD:278512	17/58 (29%)
Svep1	XP_038966967.1	VWA	222..396	CDD:395045
		Ephrin_rec_like	448..498	CDD:400166
		CCP	516..572	CDD:153056
		CCP	576..632	CDD:153056
		HYR	697..779	CDD:367105
		DUF5011	781..859	CDD:413762
		Ephrin_rec_like	1141..1188	CDD:400166
		Ephrin_rec_like	1195..1242	CDD:400166
		Ephrin_rec_like	1249..1296	CDD:400166
		EGF	1333..1361	CDD:394967
		EGF_CA	1367..1403	CDD:238011
		EGF_CA	1405..1441	CDD:238011
		EGF_CA	1443..1479	CDD:238011
		EGF_CA	1481..1517	CDD:238011
		EGF_CA	1519..1555	CDD:238011
		PTX	1560..1758	CDD:238086
		PHA02927	1780..2036	CDD:222943
		EGF_CA	1881..1919	CDD:214542
		PHA02817	2036..>2145	CDD:165167
		PHA02927	2111..2335	CDD:222943
		PHA02927	2230..2455	CDD:222943
		PHA02831	2414..>2572	CDD:165176
		PHA02927	2537..2745	CDD:222943
		Sushi	2796..2847	CDD:395037	3/5 (60%)
		PHA02639	2849..>3022	CDD:165022	37/210 (18%)
		PHA02927	<2963..3138	CDD:222943	40/203 (20%)
		PHA02927	3150..3365	CDD:222943	43/224 (19%)
		PHA02927	3370..3602	CDD:222943	56/188 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11030
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D31246at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920