DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hig and Hasp

DIOPT Version :9

Sequence 1:	NP_724773.1	Gene:	hig / 35949	FlyBaseID:	FBgn0010114	Length:	958	Species:	Drosophila melanogaster
Sequence 2:	NP_001137842.2	Gene:	Hasp / 35238	FlyBaseID:	FBgn0032797	Length:	1677	Species:	Drosophila melanogaster

Alignment Length:	1087	Identity:	259/1087 - (23%)
Similarity:	397/1087 - (36%)	Gaps:	314/1087 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 LHVGDAAASLVGDD----DLGDEDEDHHGDPEDKRLNANRKQGKRRRAGSGR------------- 165
            |.||...|:.||..    ||.......|     .||..||   :|||:...|
  Fly   626 LEVGPPGATCVGGKWRPLDLPQCLLGQH-----PRLRWNR---RRRRSLQIRQLRSMYLLQRQRQ 682

  Fly   166 --RRRIENEN-----GQTGRGRGSRYKRHAILHDTEA--SPETDRWAGSKLAAEGDVYYVHIAD- 220
              |:.|:|:|     ....:....|.||.|..|....  :.:.|| |.||       ||..|.:
  Fly   683 LQRQLIDNQNYIKAIADPVQPSVHRVKRSASPHPNSQPYASDVDR-AYSK-------YYQKIKER 739

  Fly   221 ----ILKSREPNRELKSKLHKLKMKARLNKCL--AEGGKEKCTRLLKKKPKKKVVEKEQTLKKEK 279
                :.|....:| :..:||......|:...|  .:||                   :.|::.:.
  Fly   740 YQRYVRKMLGRDR-IYQRLHSQDAVGRVGNNLNTHDGG-------------------QVTMRGKS 784

  Fly   280 KFPKEEQSKEKVPENG-----------------------------QTPKEDELELDHPETAA-AH 314
            .|.:.|.....:...|                             :||||:.|....|..|: :.
  Fly   785 NFREFENGNNYLGSGGIGSGGVVGSGVVALPNINQASRNHQVHVNRTPKEELLSNGSPPIASRSL 849

  Fly   315 HRRRGDSHAAELDQRDRSPRWRRRRSTEFKGDLGQLPPESGIGPEPEPLADQDLKDLQQYGNQSS 379
            |.....|:..:|  :.:..|.|||||:    .:||.||.||   ...|.|:.|:.|..:.|....
  Fly   850 HLNATRSYIEQL--KSQIVRRRRRRSS----SIGQSPPPSG---ATIPDAEVDISDGGEAGKGGG 905

  Fly   380 SARV-----ALLWQRVKR----KSGKTTGALS---------------RPKGGGDSSSKTTSRKDK 420
            ..|:     .|.|.....    :.||..|..:               ..||     ...|:|..:
  Fly   906 GKRLRGPCEELEWDSFANVTTVRPGKVPGRNAVGIMLHLECNAGFKLNIKG-----ENATARCIR 965

  Fly   421 GIYD----------------EEAGYTPIHP------DDPEFD-----EEEEEDEEVDI------- 451
            ||:.                |...|..:.|      |.|...     ||.:.:|.:.:
  Fly   966 GIWKPETPKCLSAPCLVPAVEHGQYYKVEPHTKQLSDKPSLTPLSTYEEIQSNEFITLECEDGFN 1030

  Fly   452 ---------------LQQFTEVSEI-----RFPGEIGPMGDRR------------LCKI------ 478
                           :..|:|.:.:     ..||.|...|.|.            .|::
  Fly  1031 IQGSAQLRCAHGSWSVNAFSECTSVPCTLPNIPGVIYDGGYRAGLTIGHGSSVSVRCELSTNANP 1095

  Fly   479 ---RCVKGKWVGPL--CAT--------------------------NEED--DNGNVKFQPLYKSC 510
               .|.||....|.  |.:                          |:.|  |||..:...: |.|
  Fly  1096 IEMSCHKGILTPPSIPCESGLRKSREELEHATPTPHPKVEHNELDNDHDHHDNGTDEHDDM-KMC 1159

  Fly   511 HVNRIPSHLLLSYRN---------------ISVTPIPPNRGWRKT-RL---------------SK 544
            ....:....|: |:|               |....||...|.|:| |:               :.
  Fly  1160 GPPMLTDGALV-YKNADHPELDGAYESGTEIFFNCIPNAAGDRQTWRIICDNGLWIGRSYNCENG 1223

  Fly   545 STLLSNTEINV------------GWDLPHGHSLQARCQELGIYKLLGESRVLCSNGLWAPRMPSC 597
            :.:..|.|.||            ..|.|.|.::.:||.::|.:..:|.....|.:..|....|.|
  Fly  1224 TCVFRNNEANVVSFYNDLEIREDVVDFPPGATIISRCMDIGKFSFMGSHERTCIHSEWTNTKPVC 1288

  Fly   598 VPTTVLTNYSEDSAPSIRIKIFNGSHSFEPSGVMAVPPHSTVLMDCMYPRVRGTPEWSWTSWYMQ 662
            .......:|:.:.||:|..:..||..:....|.:.|.|.:|:.|:|::.|..|.|:|:.:..:..
  Fly  1289 SGLNQENDYAMEKAPTILFRHQNGPIAQSNDGKLIVYPGTTLHMECLWMRRFGNPKWNVSHTHKN 1353

  Fly   663 YSTGWSPAQEE---KAVRYRLSIKNIENNDSGTFTCTSPRGLTNSIAVVVATSTCPQLTEPLAPL 724
            |:.||....:|   ..:.|||||.:..::|||.::|.:|....:::.|||....||::     |:
  Fly  1354 YTEGWVTEADEGRDSTLEYRLSIVDAASDDSGFYSCMTPARHEHTVEVVVRAINCPEI-----PM 1413

  Fly   725 KLRLEGN----KLGQRAHYECPEGFRLDGAWNATCLASGNWSSPTPTCHAIQCPRLEL------D 779
            :..|..|    ||..||...|..|..|.||....||.|||||:|.|.|.:::|..:.|      .
  Fly  1414 RRGLIVNTNDTKLSTRALLSCANGNSLIGASELFCLPSGNWSAPLPVCESVECGDIPLGMGSNAS 1478

  Fly   780 DPHLSLIELNTSAWGRAVFKCQWGFKLTGPAQLDCEPSGVWSGPVPRCKVIQCVMPVAPLNGRIG 844
            .|.:|:  |:....|||.|.|..|:.|.|||:..|.|:|.||.|:|.|..:||..|.||.||...
  Fly  1479 SPRVSV--LSREVGGRAAFSCASGYGLRGPAEAICNPTGEWSAPLPTCVEVQCDNPGAPQNGYAQ 1541

  Fly   845 GTSLSQRRLTVGALVTFSCNDGHSLVGESSIICTENGQWSHSPPFCKSQCPYPGDPPNGLIAPLK 909
            |::    ....|.:|.|:||..:.:.|:..|.|.:|.:||...|.|...|.|||...:|.::.:|
  Fly  1542 GSA----PYRAGDVVQFNCNPEYMMQGQPIIACQDNARWSGGLPKCVQACSYPGTVISGRMSSVK 1602

  Fly   910 FNYDAGDYLSVQCRPGFVQSYEGPPERPKCQPDGRWSGPMPKCKSYE 956
            |.|..|:.::..|..|.  ...| .:..||..:|:||..:|.|.:.|
  Fly  1603 FYYAIGESITFTCDAGL--DLRG-SKVLKCLKNGKWSSAIPTCVTNE 1646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hig	NP_724773.1	PHA02927	705..952	CDD:222943	89/256 (35%)
		CCP	714..768	CDD:153056	23/57 (40%)
		CCP	<795..828	CDD:153056	16/32 (50%)
		CCP	832..891	CDD:153056	19/58 (33%)
		Sushi	894..952	CDD:278512	18/57 (32%)
Hasp	NP_001137842.2	PHA02927	114..360	CDD:222943
		CCP	121..175	CDD:153056
		CCP	180..241	CDD:153056
		CCP	245..300	CDD:153056
		CCP	307..361	CDD:153056
		CCP	365..420	CDD:214478
		PHA02927	<497..>654	CDD:222943	9/32 (28%)
		Sushi	515..576	CDD:278512
		PHA02927	<946..1111	CDD:222943	26/169 (15%)
		CCP	1408..1462	CDD:153056	23/58 (40%)
		CCP	<1488..1525	CDD:153056	17/36 (47%)
		CCP	1529..1584	CDD:153056	19/58 (33%)
		CCP	1587..1643	CDD:153056	18/58 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D31246at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19325
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.020