DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hig and lev-9

DIOPT Version :9

Sequence 1:	NP_724773.1	Gene:	hig / 35949	FlyBaseID:	FBgn0010114	Length:	958	Species:	Drosophila melanogaster
Sequence 2:	NP_001335574.1	Gene:	lev-9 / 188252	WormBaseID:	WBGene00002976	Length:	1347	Species:	Caenorhabditis elegans

Alignment Length:	530	Identity:	145/530 - (27%)
Similarity:	225/530 - (42%)	Gaps:	68/530 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   478 IRCVKGKWVGPL--CA----TNEEDDNGNVKFQPL-----YKSCHV-NRIPSHL----------- 519
            |.||.|:||..|  |.    ||.:....:....||     .|..:| |.||.|:
Worm   826 IECVNGEWVSNLLPCVTANITNWKTPTNDEMCPPLRLELNQKIFNVENYIPHHMHLFAHGTILNV 890

  Fly   520 --LLSYRNISVTPIPPNRG-W---RKTRLSKSTLLSNTEINV-----------------GWDLPH 561
              |.:..:....||...|| |   :|...||:..:...::|:                 ..:...
Worm   891 GCLTTSNSAETVPIKCRRGKWGYKKKLNCSKTETICTLKMNINSHTVIYHTQKKETVVFNQNFES 955

  Fly   562 GHSLQARCQELGIYKLLGESRVLCSNGLWAPRMPSCVPTTVLTNYSEDSAPSIRIKIFNGSHSFE 626
            |..|..||..:|:.:|.|:..:.|.||:|:..:|.|:|...    :..|.| |:..:.:|:|:..
Worm   956 GSKLLFRCANIGLEQLHGKKELQCYNGVWSSPIPYCIPIQA----TGTSVP-IKYSVTHGTHAIS 1015

  Fly   627 PSGVMAVPPHSTVLMDCMYPRVRGTPEWSWTSWYMQYSTGWSPAQE---EKAVRYRLSIKNIENN 688
            ..|.:.|...:.|.:.|:..:|...|.|..||.|..|.|.|:.|:.   :....:.:||.:::..
Worm  1016 SKGELIVSRAANVKLACLTEKVASDPIWKVTSTYRSYPTQWTKAKTGDYDDIDGFEISIASVQPF 1080

  Fly   689 DSGTFTCTSPRGLTNSIAVVVATSTCPQLTEPLAPLKLRLEGNK----LGQRAHYECPEGFRLDG 749
            |||...|..|.|..|||.::|....|   ..|:.|..|:::.:.    :|..|.:.||.||.::|
Worm  1081 DSGMLHCVLPNGARNSIKLIVHEEKC---LLPIGPTNLQVDLSSPTLFVGTVAQFSCPPGFSVEG 1142

  Fly   750 AWNATCLASGNWSSPTPTCHAIQCPRLELDDPHLSLIELNTSAWGRAVFKCQWGFKLTGPAQLDC 814
            :..:|||....||...|.|.|..||.:.::...:::...:....|.|.|||..||.|.|...|.|
Worm  1143 SAVSTCLEDATWSHSAPRCVAAHCPAVFVNGTRMTVTVTSYRTGGVAHFKCHKGFTLIGEQNLHC 1207

  Fly   815 EPSGVWSGPVPRCKVIQCVMPVAPLNGRIGGTSLSQRRLTVGALVTFSCNDGHSLVGESSIICTE 879
            ...|.||...|.|.|:.|...:.|.||...|.  .:...|.|.:|...|...:.|.|....:|..
Worm  1208 TTQGTWSHDFPYCNVVHCPPLLPPANGHFIGE--PKEINTKGDIVLLGCLPNYMLTGGDFSVCQA 1270

  Fly   880 NGQWSHSPPFCKSQCPYPGDPPNGLIAPL-KFNYDAGDYLSVQCRPGFVQSYEGPPERP-KCQPD 942
            :|:||.....|...|.:||.|.:|....: |..|..|:.:...| |.  |:|:...:.. .|...
Worm  1271 DGEWSEIKTKCDGYCRHPGQPDHGATTTIAKDYYSIGEKIVFYC-PS--QNYKLSSDNVLVCISP 1332

  Fly   943 GRWSGPMPKC 952
            |:||..:|.|
Worm  1333 GQWSRRLPLC 1342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hig	NP_724773.1	PHA02927	705..952	CDD:222943	73/252 (29%)
		CCP	714..768	CDD:153056	17/57 (30%)
		CCP	<795..828	CDD:153056	14/32 (44%)
		CCP	832..891	CDD:153056	15/58 (26%)
		Sushi	894..952	CDD:278512	17/59 (29%)
lev-9	NP_001335574.1	WAP	18..61	CDD:320786
		CCP	64..119	CDD:153056
		CCP	127..363	CDD:332582
		CCP	<377..557	CDD:332582
		CCP	1106..1343	CDD:332582	72/245 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D31246at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010