Protein Alignment hig and F13b

DIOPT Version :10

• Sequence 1: NP_724773.1
• Gene: hig / 35949
• FlyBaseID: FBgn0010114
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_112441.2
• Gene: F13b / 14060
• MGIID: 88379
• Length: 669
• Species: Mus musculus
• Alignment Length: 626
• Identity: 143/626 - (22%)
• Similarity: 220/626 - (35%)
• Gaps: 179/626 - (28%)

  Fly   407 GGDSSSKTTSRKDKG-IYDEEAGYTPIHPDDPEFDEEEE-------EDEEVDILQQFTEVSEI-- 461
            |..|..|||..||:. ::...||::    ..|...:|:|       |.......|:..:|.:|
Mouse   118 GCSSGYKTTGGKDEEVVHCLSAGWS----SQPSCRKEQETCLAPELEHGNYSTTQRTFKVKDIVA 178

  Fly   462 ------------RFPGE---------IGPMGDRRLC-KIRCVKGKWVGPLCATNEEDDNGNVKFQ 504
                        :..||         :.|..::.:| .:|.::..:..|:..|.||.|  .|:|
Mouse   179 YTCTAGYYTTTGKQTGEAECQANGWSLTPQCNKLMCSSLRLIENGYFHPVKQTYEEGD--VVQF- 240

  Fly   505 PLYKSCHVNRI--PSHLLLSYRNISVTPIPPNRGW---------RKTRLSKSTLLSNTEINVGWD 558
                .||.|..  .|.|:..|          |.||         |:.|.....:..|::|.
Mouse   241 ----FCHENYYLSGSDLIQCY----------NFGWYPESPICEGRRNRCPPPPVPLNSKIQ---- 287

  Fly   559 LP------HGHSLQARCQELGIYKLLGESRVLCSNGLWAPRMPSCVPTTVLTNYSEDSAPSIRIK 617
             |      ||..:...| ||. :.:.|...:||.||.|. ..|.|:...  ...:.:..||:.
Mouse   288 -PHSTTYRHGERVHIEC-ELN-FVIQGSEELLCENGKWT-EPPKCIEEK--EKVACEQPPSVE-- 344

  Fly   618 IFNG-SHSFEPSGVMAVPPHSTVLM--DCMYPRVRGTPEWSWTSWYMQYSTGWSPAQEEKAVRYR 679
              || :|           |||.:..  |.:..|..|......:|........|:...|
Mouse   345 --NGVAH-----------PHSEIYYSGDKVTYRCGGGYSLRGSSTITCNRGRWTLPPE------- 389

  Fly   680 LSIKNIENNDSGTFTCTSPRGLTNSIAV--VVATSTCPQLTEPLAPLKLRLEGNKLGQRAHYECP 742
             .::||||       |..|..:.|.:.|  ::|:.|                   .|....|.|.
Mouse   390 -CVENIEN-------CKPPPDIANGVVVDGLLASYT-------------------TGSSVEYRCN 427

  Fly   743 EGFRLDGAWNATCLASGNWSSPTPTCHAIQCPRLELDDPHLSLIELNTSAWGRAV------FKCQ 801
            |.:.|.|:..:.| ..|.|||| |.|  ::...:::|..:.:.|:|.....|:.:      |.|:
Mouse   428 EYYLLKGSETSRC-EQGAWSSP-PVC--LEPCTIDVDHMNRNNIQLKWKYEGKILHGDLIDFVCK 488

  Fly   802 WGFKLTGPAQL-----DCEPSGVWSGPVPRC----KVIQCVMPVAPLNGRIGGTSLSQRRLTVGA 857
            .|:.|:....|     .|....|   ..|.|    ....|..|....||.|  .|.:.|....|:
Mouse   489 QGYNLSPSIPLSEISAQCNRGDV---RYPMCIRKESKGMCASPPVIRNGDI--VSSAARTYENGS 548

  Fly   858 LVTFSCNDGHSLVGESSIICTENGQWSHSPPFCKSQCPYPGDPPNGLIAPLKFNYD------AGD 916
            .|.:.|.|.|.|.|..::.|.: |.|: :||.|...|.......:.....||:|:|      .|:
Mouse   549 SVEYRCFDNHFLQGSQNVYCVD-GVWT-TPPSCLEPCTLSFVEMDKNYLQLKWNFDNRPLILHGE 611

  Fly   917 YLSVQC-RPGF------------VQSYEGPPERPKCQPDGR 944
            |:...| |..:            ||...|..:.|||.|..|
Mouse   612 YIEFMCKRDAYISETSIAGSVLRVQCDRGRLKYPKCTPRDR 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hig	NP_724773.1	Ig_3	612..696	CDD:464046	18/86 (21%)
		PHA02927	705..952	CDD:222943	67/276 (24%)
F13b	NP_112441.2	PHA02927	51..268	CDD:222943	37/170 (22%)
		PHA02927	165..452	CDD:222943	80/366 (22%)
		CCP	275..329	CDD:153056	15/61 (25%)
		CCP	525..579	CDD:153056	19/57 (33%)