Protein Alignment hig and CR1L

DIOPT Version :10

• Sequence 1: NP_724773.1
• Gene: hig / 35949
• FlyBaseID: FBgn0010114
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_783641.1
• Gene: CR1L / 1379
• HGNCID: 2335
• Length: 569
• Species: Homo sapiens
• Alignment Length: 610
• Identity: 137/610 - (22%)
• Similarity: 204/610 - (33%)
• Gaps: 200/610 - (32%)

  Fly   462 RFPG--------EIGPMGDRRLCKIRCVKGKWVGPLCATNEEDDNG-------NVKFQPLY---- 507
            ||||        .:....|      :|...:|:.....||..||..       |.:.:|.|
Human    15 RFPGLLLAALVLLLSSFSD------QCNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRP 73

  Fly   508 --------------------KSCH-----VNRIPSHLL--LSYRNISVTPIPPNRGWRKTRLSKS 545
                                |||.     ||.: :|::  :.:|:......|  :|:|....|.:
Human    74 FSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGM-AHVIKDIQFRSQIKYSCP--KGYRLIGSSSA 135

  Fly   546 TLL--SNTEINVGWD------------LP-----------------HGHSLQARCQELG-----I 574
            |.:  .||.|   ||            ||                 :|..:...| .||     :
Human   136 TCIISGNTVI---WDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHC-NLGSRGKKV 196

  Fly   575 YKLLGESRVLCSN-----GLWAPRMPSCVPTTVLT--NYSEDSAPSIRIKIFNGSHSFE----PS 628
            ::|:||..:.|::     |:|:...|.|:.....|  |.......|....:|:.:...|    |.
Human   197 FELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPG 261

  Fly   629 GVMAVPPHSTVLMDCMYPRVRGTPEWSWTSWYMQYSTGWSPAQEEKAVRYRLSIKNIENNDSGTF 693
            ..|..|.|    :.|                  |....|.|
Human   262 FGMKGPSH----VKC------------------QALNKWEP------------------------ 280

  Fly   694 TCTSPRGLTNSIAVVVATSTCPQLTEPLAPLKLRLEGNKL-------GQRAHYECPEGFRLDGAW 751
                            ...:|.::.:| .|..|..|..:.       ||...|.|..|:.|.|:.
Human   281 ----------------ELPSCSRVCQP-PPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGST 328

  Fly   752 NATCLASGNWSSPTPTCHAIQCPRL--ELDDPHLSLIELNTSAWGRAVFKCQWGFKLTGPAQLDC 814
            ...|...|:||...|.|....|...  :|.:.|: |..||.....:..|.|..||:|.|.:...|
Human   329 YLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHV-LFPLNLQLGAKVDFVCDEGFQLKGSSASYC 392

  Fly   815 EPSG---VWSGPVPRCKVIQCVMPVAPLNGRIGGTSLSQRRLTVGALVTFSCNDGHSLVGESSII 876
            ..:|   :|:..||.|:...|..|..|:||.:...:    .:.||:.:.:||..||.|:|.||..
Human   393 VLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVIT----DIHVGSRINYSCTTGHRLIGHSSAE 453

  Fly   877 CTENG---QWSHSPPFCKS-QCPYPGDPPNG--LIAPLKFNYDAGDYLSVQCRP----GFVQSYE 931
            |..:|   .||..||.|:. .||.|....||  ...||. :...|..:|..|.|    |...:..
Human   454 CILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLG-DIPYGKEVSYTCDPHPDRGMTFNLI 517

  Fly   932 GPPE-RPKCQPDGR--WSGPMPKCK 953
            |... |...:|.|.  ||.|.|:|:
Human   518 GESTIRRTSEPHGNGVWSSPAPRCE 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hig	NP_724773.1	Ig_3	612..696	CDD:464046	11/87 (13%)
		PHA02927	705..952	CDD:222943	78/271 (29%)
CR1L	NP_783641.1	PHA02927	35..287	CDD:222943	54/320 (17%)
		PHA02927	284..541	CDD:222943	78/263 (30%)